Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634614 |
Pattern: |
Not Specified |
Stage: |
TS14 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.0 |
Image: |
1B left |
|
Specimen Label: |
1B left |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634614 |
Pattern: |
Not Specified |
Stage: |
TS14 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.0 |
Image: |
1B right |
|
Specimen Label: |
1B right |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.5 |
Image: |
1C left |
|
Specimen Label: |
1C left |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1634615 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.5 |
Image: |
1C right |
|
Specimen Label: |
1C right |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429852 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-04-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611719 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:7464048 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S1 E11.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635013 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 8.5 |
Image: |
1A left |
|
Specimen Label: |
1A left |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635013 |
Pattern: |
Not Specified |
Stage: |
TS13 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 8.5 |
Image: |
1A right |
|
Specimen Label: |
1A right |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635014 |
Pattern: |
Not Specified |
Stage: |
TS14 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.0 |
Image: |
1B left |
|
Specimen Label: |
1B left |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635014 |
Pattern: |
Not Specified |
Stage: |
TS14 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.0 |
Image: |
1B right |
|
Specimen Label: |
1B right |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635015 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.5 |
Image: |
1C left |
|
Specimen Label: |
1C left |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6887674 |
Assay Type: |
RNA in situ |
Annotation Date: |
2022-03-10 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1635015 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:6887749 |
Age: |
embryonic day 9.5 |
Image: |
1C right |
|
Specimen Label: |
1C right |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429852 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-02-24 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618415 |
Pattern: |
Not Specified |
Stage: |
TS15 |
Assay Id: |
MGI:4429946 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
Table S4 - E9.5 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429852 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-02-24 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:4429946 |
Age: |
embryonic day 10.5 |
|
|
Specimen Label: |
Table S4 - E10.5 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4429852 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-02-24 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1618419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:4429946 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S4 - E11.5 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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UniProt Feature |
Begin: |
1 |
Description: |
Histone-lysine N-methyltransferase Smyd1 |
Type: |
chain |
End: |
490 |
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HT Experiment |
Series Id: |
GSE71679 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Publication |
First Author: |
Sirinupong N |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Crystal structure of cardiac-specific histone methyltransferase SmyD1 reveals unusual active site architecture. |
Volume: |
285 |
Issue: |
52 |
Pages: |
40635-44 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
490
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
456
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
477
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
21
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
58
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
69
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Fragment?: |
false |
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Publication |
First Author: |
Just S |
Year: |
2011 |
Journal: |
J Cell Sci |
Title: |
The myosin-interacting protein SMYD1 is essential for sarcomere organization. |
Volume: |
124 |
Issue: |
Pt 18 |
Pages: |
3127-36 |
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GXD Expression |
Probe: |
MGI:6887676 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-03-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6887757 |
Age: |
postnatal |
Image: |
4E |
Note: |
Co-expression of Smyd1 and Ash2l was noted in the nuclei and cytoplasm of cardiomyocytes. |
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
1 |
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GXD Expression |
Probe: |
MGI:6887676 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-03-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3268828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6887757 |
Age: |
postnatal |
Image: |
4E |
Note: |
Co-expression of Smyd1 and Ash2l was noted in the nuclei and cytoplasm of cardiomyocytes. |
Specimen Label: |
4E |
Detected: |
true |
Specimen Num: |
1 |
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Publication |
First Author: |
Ye X |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
SMYD1, an SRF-Interacting Partner, Is Involved in Angiogenesis. |
Volume: |
11 |
Issue: |
1 |
Pages: |
e0146468 |
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SET domain of SET and MYND domain-containing protein 1 (SMYD1). SMYD1 functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organisation, as well as in the regulation of endothelial cells (ECs) [, ]. It is expressed in vascular endothelial cells, it has been shown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation [].The SMYD family consists of five members including SMYD1/2/3/4/5. They contain two highly conserved structural and functional domains, the SET and MYND domains. The SET domain is involved in lysine methylation, while the MYND domain is involved in protein-protein interaction. They are essential in several mammalian developmental pathways [, , , ]. |
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Publication |
First Author: |
Li D |
Year: |
2009 |
Journal: |
Nucleic Acids Res |
Title: |
SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin. |
Volume: |
37 |
Issue: |
21 |
Pages: |
7059-71 |
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Publication |
First Author: |
Voelkel T |
Year: |
2013 |
Journal: |
Biochim Biophys Acta |
Title: |
Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. |
Volume: |
1833 |
Issue: |
4 |
Pages: |
812-22 |
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Publication |
First Author: |
Du SJ |
Year: |
2014 |
Journal: |
Anat Rec (Hoboken) |
Title: |
SMYD proteins: key regulators in skeletal and cardiac muscle development and function. |
Volume: |
297 |
Issue: |
9 |
Pages: |
1650-62 |
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Publication |
First Author: |
Mitchell LH |
Year: |
2016 |
Journal: |
ACS Med Chem Lett |
Title: |
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. |
Volume: |
7 |
Issue: |
2 |
Pages: |
134-8 |
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Publication |
First Author: |
Sweis RF |
Year: |
2015 |
Journal: |
ACS Med Chem Lett |
Title: |
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. |
Volume: |
6 |
Issue: |
6 |
Pages: |
695-700 |
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Publication |
First Author: |
Jarrell DK |
Year: |
2020 |
Journal: |
Vet Sci |
Title: |
Characterizing the Role of SMYD2 in Mammalian Embryogenesis-Future Directions. |
Volume: |
7 |
Issue: |
2 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
477
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Fragment?: |
false |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
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Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
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Pages: |
19-44 |
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Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
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Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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