This entry represents a domain found in class IV histone deacetylases (), also known as histone deacetylase 11 (HDAC11) [, ]. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation) []. HDAC11 and HDAC6 interact with each other in the cytoplasm and nuclei of APCs (antigen presenting cells) and are recruited to the IL-10 gene promoter to regulate its transcriptional activity [].In mammals, HDAC11 proteins are known to be involved in progression of various tumours. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients [].
