This entry includes ARHGAP11A and ARHGAP11B from humans. ARHGAP11B gene arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage []. A lack of 55 nucleotides in ARHGAP11B mRNA leads to loss of RhoGAP activity by GAP domain truncation and addition of a human-specific C-terminal amino acid sequence []. ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion [].
