cAMP-responsive element-binding protein 1 (CREB1) is a phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters [, ]. CRE has the sequence 5'-TGACGTCA-3' []. Transcription is stimulated on binding to the CRE of a phosphorylated CREB dimer, which is held together by leucine zippers.CREB1 plays a key role in neural development [, ]. CREB1 signaling pathway can influence mood, addiction, learning and memory by activating an array of proteins [].
