This entry represents CXXC-type zinc finger proteins CXXC4 and CXXC5. CXXC4 is a potential tumour suppressor directly regulated by EZH2 []. It has been shown to inactivate mitogen activated protein kinase signaling []. CXXC5 is a retinoid-inducible nuclear factor (RINF) involved in normal myelopoiesis []. It has been associated with various malignant tumours [].