This family contains a number of eukaryotic etoposide-induced 2.4 (ei24) proteins. In cells treated with the cytotoxic drug etoposide, ei24 is induced by p53 and may play an important role in negative cell growth control by functioning as an apoptotic effector of p53 tumor suppressor activities []. These proteins regulate the formation of degradative autolysosomes during autophagy [, ].
