This entry includes Gde1 from yeasts and GPCPD1 from mammals. Gde1 is a glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline [, ].GPCPD1 (also known as GDE5) controls skeletal muscle development via a non-enzymatic mechanism [].