G protein-coupled receptor 12 (GPR12) was initially isolated from a rat pituitary library, and is found in discrete regions of the brain, pituitary and testis, but is absent in other tissues [, ]. Three human homologues (GPR12, GPR6 and GPR3) have also been isolated []. The 3 genes have been localised to human chromosomal regions 13q12, 6q21and 1p34.3-p36.1 respectively.This entry represents G protein-coupled receptor 6, which is an orphaned receptor, no endogenous ligand having yet been identified.
Amongst the rhodopsin-like GPCRs are a family of orphan receptors whose members are designated GPR3, GPR6 and GPR12. Whilst these receptors do show sequence similarity to other rhodopsin-class GPCRs, the overall degree of similarity is very low, and evidence that they are functional GPCRs has not yet been gathered experimentally.
G protein-coupled receptor 12 (GPR12) was initially isolated from a rat pituitary library, and is found in discrete regions of the brain, pituitary and testis, but is absent in other tissues [, ]. Three human homologues (GPR12, GPR6 and GPR3) have also been isolated []. The 3 genes have been localised to human chromosomal regions 13q12, 6q21and 1p34.3-p36.1 respectively.This entry represents G protein-coupled receptor 12. It is an orphaned receptor, with no endogenous ligand having yet been identified.
G protein-coupled receptor 12 (GPR12) was initially isolated from a rat pituitary library, and is found in discrete regions of the brain, pituitary and testis, but is absent in other tissues [, ]. Three human homologues (GPR12, GPR6 and GPR3) have also been isolated []. The 3 genes have been localised to human chromosomal regions 13q12, 6q21and 1p34.3-p36.1 respectively.This entry represents the G protein-coupled receptor 3. It is an orphaned receptor, with no endogenous ligand having yet been identified.
