LDAF1, also known as Promethin, is expressed in a variety of mammalian tissues including the adipose tissue, heart, kidney, and at lower levels in lung, liver, skeletal muscle and testis. It is up-regulated in liver with hepatic adiposis caused by PPARgamma (peroxisome proliferator-activated receptor-gamma) overexpression [].LDAF1 has been shown to form a lipid droplet assembly complex with seipin [].
