This entry includes Mad2 and Mad2-like proteins, including Mad2/Rev7 from yeasts and MAD2A/B from animals. Mad2 is a central component of the spindle assembly checkpoint, which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis [, ]. Rev7 (also known as MAD2L2 or MAD2B) is an accessory subunit of DNA polymerase zeta []. It also acts as an interaction module in a broad array of cellular pathways, including translesion DNA synthesis, cell cycle control, and nonhomologous end joining [].
