This is a cyclophilin-type peptidylprolyl cis-trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). It is found in a number of eukaryotic cyclophilins having the RRM domain, including the nuclear proteins: human cyclophilin-like protein PPIL4 [], Arabidopsis thaliana AtCYP59 [], Caenorhabditis elegans sig-7 []and Paramecium tetrurelia Kin241. The Kin241 protein has been shown to have a role in cell morphogenesis [].
The name CRIP, for cyclophilin-RNA interacting protein, has been proposed for this family of proteins that comprise a cyclophilin-type peptidyl-prolyl isomerase domain, an RNA recognition motif, followed by a region rich in glutamate and lysine (EK domain) and a C-terminal string of serines []. The family includes among others Paramecium tetraurelia KIN241 [], human cyclophilin-like protein PPIL4 [], Arabidopsis thaliana AtCYP59 [], and Caenorhabditis elegans sig-7 [].
