This entry represents the Pus 10 family of tRNA pseudouridine synthases. Family members are responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs []. The family appears to be distinct from the five commonly identified families of Psi synthases [].
Archaeal Pus10 is responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs []. This entry also includes Pus10 homologues from eukaryotes. Human Pus10 homologue is a modulator of TRAIL-induced cell death and is required for the progression of the apoptotic signal through intrinsic mitochondrial cell death [, ]. Although eukaryotic Pus10 shares a conserved catalytic domain with archaeal Pus10 genes, their biological roles are not resolved [].
