This entry represents a conserved linker between the second and the third RRM domain in human RBM39 (also known as CAPER) protein and other RNA splicing proteins. CAPER is a transcriptional coactivator of activating protein-1 (AP-1) and estrogen receptors (ERs). This linker was implicated in interactions with ERalpha and ERbeta []. Preliminary results from JCSG suggest that this is a structured domain with a well defined fold.
This entry represents RBM39 (also known as CAPER) proteins from mammals and a group of putative RNA splicing factors including the Pad1 protein from fungi. All are characterised by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 human paralogs, two) RNA recognition domains. These proteins are closely related to the U2AF splicing factor family (). In mice, CAPER is a transcriptional coactivator of activating protein-1 (AP-1) and estrogen receptors (ERs) []. It may be involved in pre-mRNA splicing process.
