Sorting nexin-17 (SNX17) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides []. SNX17 also possess an additional FERM-like domain [].SNX17 is a critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. It binds to Asn-Pro-Xaa-Tyr (NPxY) sequences in the cytoplasmic tails of cargo such as LDL receptors and the amyloid precursor protein [].
SNX17 is a critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. It binds to Asn-Pro-Xaa-Tyr (NPxY) sequences in the cytoplasmic tails of cargo such as LDL receptors and the amyloid precursor protein []. SNX17 contains a defining PtdInsP-binding PX domain, and a C-terminal 4.1, ezrin, radixin, moesin (FERM) domain with an atypical tertiary structure. This entry represents the FERM-like domain of SNX17. SNX17 binds Ras GTPase through its FERM-like domains [].
This domain can be found at C terminus of sorting nexin 17 (SNX17)and sorting nexin 31 (SNX31). SNX17 localizes to early endosomes where it directly binds NPX(Y/F) motifs in the target receptors to mediate their rates of endocytic internalization, recycling, or degradation. The domain is known as terminal band 4.1/ezrin/radixin/moesin (FERM) domain. The FERM domain binds directly to the common motif, NPX(Y/F), in the cytoplasmic region of its target proteins [].
