This entry includes TCF25 from animals and Rqc1 from budding yeasts. Rqc1 is a component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation []. TCF25 may act by increasing histone deacetylase activity at promoter regions [].