Tectonin β-propeller repeat-containing protein 2 probably plays a role as positive regulator of autophagy []. Mutations in TECPR2 gene cause Spastic paraplegia 49, autosomal recessive (SPG49), which is a form of spastic paraplegia, a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limb [].This entry also includes WD repeat-containing protein CG11141 from Drosophila melanogaster. The function of CG11141 is not clear.
