WD repeat domain phosphoinositide-interacting protein 4 (WIPI4, also known as WDR45) is one of the four mammalian homologues of yeast Atg18, which has an important role in autophagy. In C.elegans the WIPI4 homologue, EPG-6, has been shown to regulate progression of omegasomes to autophagosomes []. Mutations in the WDR45 gene cause the neurodegenerative disease NBIA (neurodegeneration with brain iron accumulation) [].
