|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 1505 for Akt1

Category restricted to Publication (x)

<< First    < Previous  |  Next >    Last >>
0.043s

Categories

Category: Publication
« show all
Type Details Score
Publication
17460049 | J:121297
First Author: Ju X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Akt1 governs breast cancer progression in vivo.
Volume: 104
Issue: 18
Pages: 7438-43
•
•
•
•
•
Publication
14973226 | J:116239
First Author: Saito A
Year: 2004
Journal: J Neurosci
Title: Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Volume: 24
Issue: 7
Pages: 1584-93
•
•
•
•
•
Publication
16552185 | -
First Author: Somanath PR
Year: 2006
Journal: Cell Cycle
Title: Akt1 in endothelial cell and angiogenesis.
Volume: 5
Issue: 5
Pages: 512-8
•
•
•
•
•
Publication
16397181 | J:116422
First Author: Saito A
Year: 2006
Journal: Stroke
Title: Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Volume: 37
Issue: 2
Pages: 513-7
•
•
•
•
•
Publication
16338656 | -
First Author: Wyszomierski SL
Year: 2005
Journal: Cancer Cell
Title: A knotty turnabout?: Akt1 as a metastasis suppressor.
Volume: 8
Issue: 6
Pages: 437-9
•
•
•
•
•
Publication
9742206 | -
 
First Author: Coffer PJ
Year: 1998
Journal: Biochem J
Title: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
Volume: 335 ( Pt 1)
Pages: 1-13
•
•
•
•
•
Publication
10827191 | -
First Author: Graff JR
Year: 2000
Journal: J Biol Chem
Title: Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression.
Volume: 275
Issue: 32
Pages: 24500-5
•
•
•
•
•
Publication
15192111 | -
First Author: Xu J
Year: 2004
Journal: J Biol Chem
Title: Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation.
Volume: 279
Issue: 34
Pages: 35914-22
•
•
•
•
•
Publication
16636172 | J:122451
First Author: DeBosch B
Year: 2006
Journal: Circulation
Title: Akt1 is required for physiological cardiac growth.
Volume: 113
Issue: 17
Pages: 2097-104
•
•
•
•
•
Publication
26565903 | J:228953
First Author: Cho JH
Year: 2015
Journal: Cell Rep
Title: AKT1 Activation Promotes Development of Melanoma Metastases.
Volume: 13
Issue: 5
Pages: 898-905
•
•
•
•
•
Publication
36269831 | J:345088
First Author: Demir S
Year: 2022
Journal: Sci Adv
Title: TSC22D4 interacts with Akt1 to regulate glucose metabolism.
Volume: 8
Issue: 42
Pages: eabo5555
•
•
•
•
•
Publication
20042722 | J:160279
First Author: Calamito M
Year: 2010
Journal: Blood
Title: Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Volume: 115
Issue: 20
Pages: 4043-50
•
•
•
•
•
Publication
23935948 | J:204947
First Author: Nojima A
Year: 2013
Journal: PLoS One
Title: Haploinsufficiency of akt1 prolongs the lifespan of mice.
Volume: 8
Issue: 7
Pages: e69178
•
•
•
•
•
Publication
16763066 | J:129523
First Author: Rasoulpour T
Year: 2006
Journal: Endocrinology
Title: Akt1 suppresses radiation-induced germ cell apoptosis in vivo.
Volume: 147
Issue: 9
Pages: 4213-21
•
•
•
•
•
Publication
17957242 | J:130281
First Author: Kawamura N
Year: 2007
Journal: PLoS One
Title: Akt1 in osteoblasts and osteoclasts controls bone remodeling.
Volume: 2
Issue: 10
Pages: e1058
•
•
•
•
•
Publication
21242979 | J:170765
First Author: Hollander MC
Year: 2011
Journal: Oncogene
Title: Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Volume: 30
Issue: 15
Pages: 1812-21
•
•
•
•
•
Publication
20530873 | J:163718
First Author: Eke I
Year: 2010
Journal: J Clin Invest
Title: PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.
Volume: 120
Issue: 7
Pages: 2516-27
•
•
•
•
•
Publication
22885182 | J:188140
First Author: Choi YH
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Akt1 regulates phosphorylation and osteogenic activity of Dlx3.
Volume: 425
Issue: 4
Pages: 800-5
•
•
•
•
•
Publication
31299858 | J:293589
First Author: Nie Y
Year: 2019
Journal: Innate Immun
Title: Akt1 regulates pulmonary fibrosis via modulating IL-13 expression in macrophages.
Volume: 25
Issue: 7
Pages: 451-461
•
•
•
•
•
Publication
26921108 | J:254662
First Author: Larson-Casey JL
Year: 2016
Journal: Immunity
Title: Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis.
Volume: 44
Issue: 3
Pages: 582-596
•
•
•
•
•
Publication
20816796 | J:166615
First Author: Chang Z
Year: 2010
Journal: Dev Biol
Title: Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.
Volume: 347
Issue: 2
Pages: 384-91
•
•
•
•
•
Publication
25201081 | J:218454
First Author: Yun SJ
Year: 2014
Journal: Biochim Biophys Acta
Title: Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells.
Volume: 1842
Issue: 11
Pages: 2184-92
•
•
•
•
•
Publication
16227992 | J:102877
First Author: Chen J
Year: 2005
Journal: Nat Med
Title: Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Volume: 11
Issue: 11
Pages: 1188-96
•
•
•
•
•
Publication
24663486 | J:214152
First Author: Mukherjee A
Year: 2014
Journal: PLoS One
Title: Distinct actions of akt1 on skeletal architecture and function.
Volume: 9
Issue: 3
Pages: e93040
•
•
•
•
•
Publication
17562714 | J:124800
First Author: Somanath PR
Year: 2007
Journal: J Biol Chem
Title: Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Volume: 282
Issue: 31
Pages: 22964-76
•
•
•
•
•
Publication
23904165 | J:205816
First Author: Liu G
Year: 2013
Journal: J Immunol
Title: Kinase AKT1 negatively controls neutrophil recruitment and function in mice.
Volume: 191
Issue: 5
Pages: 2680-90
•
•
•
•
•
Publication
22117619 | J:324970
First Author: Kunuthur SP
Year: 2012
Journal: J Cell Mol Med
Title: The Akt1 isoform is an essential mediator of ischaemic preconditioning.
Volume: 16
Issue: 8
Pages: 1739-49
•
•
•
•
•
Publication
30833219 | J:294695
 
First Author: Sanchez-Gurmaches J
Year: 2019
Journal: Mol Metab
Title: Brown fat organogenesis and maintenance requires AKT1 and AKT2.
Volume: 23
Pages: 60-74
•
•
•
•
•
Publication
19491266 | J:149659
First Author: Dillon RL
Year: 2009
Journal: Cancer Res
Title: Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Volume: 69
Issue: 12
Pages: 5057-64
•
•
•
•
•
Publication
20363892 | J:160448
First Author: Beiser DG
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest.
Volume: 298
Issue: 6
Pages: H1761-8
•
•
•
•
•
Publication
19622728 | J:152016
First Author: Di Lorenzo A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.
Volume: 106
Issue: 34
Pages: 14552-7
•
•
•
•
•
Publication
25136137 | J:216407
First Author: Lee MY
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.
Volume: 111
Issue: 35
Pages: 12865-70
•
•
•
•
•
Publication
22647600 | J:185519
First Author: Arranz A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.
Volume: 109
Issue: 24
Pages: 9517-22
•
•
•
•
•
Publication
19699171 | J:151838
First Author: Androulidaki A
Year: 2009
Journal: Immunity
Title: The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Volume: 31
Issue: 2
Pages: 220-31
•
•
•
•
•
Publication
18054314 | J:130443
First Author: Fernández-Hernando C
Year: 2007
Journal: Cell Metab
Title: Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.
Volume: 6
Issue: 6
Pages: 446-57
•
•
•
•
•
Publication
24400145 | J:227956
First Author: Vandoorne K
Year: 2013
Journal: Physiol Rep
Title: Multimodal imaging reveals a role for Akt1 in fetal cardiac development.
Volume: 1
Issue: 6
Pages: e00143
•
•
•
•
•
Publication
22151747 | J:198105
First Author: Chen YC
Year: 2012
Journal: Genes Brain Behav
Title: Akt1 deficiency modulates reward learning and reward prediction error in mice.
Volume: 11
Issue: 2
Pages: 157-69
•
•
•
•
•
Publication
22064480 | J:183672
First Author: Mukherjee A
Year: 2012
Journal: Mol Cell Biol
Title: Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.
Volume: 32
Issue: 2
Pages: 490-500
•
•
•
•
•
Publication
26654940 | J:302263
First Author: Franks SE
Year: 2016
Journal: Oncotarget
Title: Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Volume: 7
Issue: 3
Pages: 3297-316
•
•
•
•
•
Publication
25868464 | J:248769
First Author: Rotllan N
Year: 2015
Journal: Circ Res
Title: Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis.
Volume: 116
Issue: 11
Pages: 1744-52
•
•
•
•
•
Publication
20354168 | J:160459
First Author: Juntilla MM
Year: 2010
Journal: Blood
Title: AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Volume: 115
Issue: 20
Pages: 4030-8
•
•
•
•
•
Publication
23787999 | J:228616
First Author: Green BD
Year: 2013
Journal: Cell Death Differ
Title: Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.
Volume: 20
Issue: 10
Pages: 1341-9
•
•
•
•
•
Publication
17077150 | J:117100
First Author: Lai WS
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.
Volume: 103
Issue: 45
Pages: 16906-11
•
•
•
•
•
Publication
22037765 | J:182721
First Author: Wan M
Year: 2012
Journal: Mol Cell Biol
Title: Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.
Volume: 32
Issue: 1
Pages: 96-106
•
•
•
•
•
Publication
16778075 | J:109600
First Author: Chen ML
Year: 2006
Journal: Genes Dev
Title: The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Volume: 20
Issue: 12
Pages: 1569-74
•
•
•
•
•
Publication
17141631 | J:129773
First Author: Boxer RB
Year: 2006
Journal: Cell Metab
Title: Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
Volume: 4
Issue: 6
Pages: 475-90
•
•
•
•
•
Publication
32931746 | J:297182
First Author: Chen X
Year: 2020
Journal: Mol Cell
Title: Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer.
Volume: 80
Issue: 1
Pages: 87-101.e5
•
•
•
•
•
Publication
25388284 | J:218209
First Author: Phung TL
Year: 2015
Journal: Cancer Res
Title: Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Volume: 75
Issue: 1
Pages: 40-50
•
•
•
•
•
Publication
30984553 | J:290242
First Author: Ha JM
Year: 2019
Journal: FEBS Open Bio
Title: Vascular leakage caused by loss of Akt1 is associated with impaired mural cell coverage.
Volume: 9
Issue: 4
Pages: 801-813
•
•
•
•
•
Publication
33038070 | J:313524
First Author: Miyazaki M
Year: 2020
Journal: Physiol Rep
Title: Transient activation of mTORC1 signaling in skeletal muscle is independent of Akt1 regulation.
Volume: 8
Issue: 19
Pages: e14599
•
•
•
•
•
Publication
27615800 | J:293081
 
First Author: Chang CY
Year: 2016
Journal: Sci Rep
Title: Akting up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions.
Volume: 6
Pages: 33095
•
•
•
•
•
Publication
29443546 | J:262191
First Author: Moriya N
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Akt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation.
Volume: 314
Issue: 5
Pages: R741-R751
•
•
•
•
•
Publication
22904301 | J:189917
First Author: Gantner BN
Year: 2012
Journal: J Immunol
Title: The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin.
Volume: 189
Issue: 6
Pages: 3104-11
•
•
•
•
•
Publication
24933620 | J:219438
 
First Author: Ahmad F
Year: 2014
Journal: Free Radic Biol Med
Title: Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.
Volume: 74
Pages: 118-28
•
•
•
•
•
Publication
32179553 | J:293069
 
First Author: Peng Z
Year: 2020
Journal: Mol Cell Biol
Title: AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells.
Volume: 40
Issue: 11
•
•
•
•
•
Publication
22930469 | J:190353
First Author: Pierau M
Year: 2012
Journal: Eur J Immunol
Title: Constitutive Akt1 signals attenuate B-cell receptor signaling and proliferation, but enhance B-cell migration and effector function.
Volume: 42
Issue: 12
Pages: 3381-93
•
•
•
•
•
Publication
21915327 | J:177888
First Author: LaRocca J
Year: 2011
Journal: PLoS One
Title: Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Volume: 6
Issue: 9
Pages: e24432
•
•
•
•
•
Publication
23300339 | J:255333
First Author: Yao Y
Year: 2013
Journal: Sci Signal
Title: BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Volume: 6
Issue: 257
Pages: ra2
•
•
•
•
•
Publication
19270695 | J:158181
First Author: Gao D
Year: 2009
Journal: Nat Cell Biol
Title: Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Volume: 11
Issue: 4
Pages: 397-408
•
•
•
•
•
Publication
31531867 | J:293787
First Author: Chen R
Year: 2020
Journal: J Pathol
Title: Akt1 signalling supports acinar proliferation and limits acinar-to-ductal metaplasia formation upon induction of acute pancreatitis.
Volume: 250
Issue: 1
Pages: 42-54
•
•
•
•
•
Publication
24742286 | J:317511
 
First Author: Wu Y
Year: 2014
Journal: BMC Cancer
Title: Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice.
Volume: 14
Pages: 266
•
•
•
•
•
Publication
17609365 | J:123155
First Author: Juntilla MM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
Volume: 104
Issue: 29
Pages: 12105-10
•
•
•
•
•
Publication
25748236 | J:311968
First Author: Albury TM
Year: 2015
Journal: Neoplasia
Title: Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression.
Volume: 17
Issue: 2
Pages: 175-82
•
•
•
•
•
Publication
25046438 | J:214225
First Author: Ma L
Year: 2014
Journal: Lab Invest
Title: Differential effects of Akt1 signaling on short- versus long-term consequences of myocardial infarction and reperfusion injury.
Volume: 94
Issue: 10
Pages: 1083-91
•
•
•
•
•
Publication
24955524 | J:217945
First Author: Kong KA
Year: 2014
Journal: Biochim Biophys Acta
Title: Akt1 mediates the posterior Hoxc gene expression through epigenetic modifications in mouse embryonic fibroblasts.
Volume: 1839
Issue: 9
Pages: 793-9
•
•
•
•
•
Publication
16982699 | J:114644
First Author: Héron-Milhavet L
Year: 2006
Journal: Mol Cell Biol
Title: Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Volume: 26
Issue: 22
Pages: 8267-80
•
•
•
•
•
Publication
22562201 | J:184520
First Author: Kent LN
Year: 2012
Journal: Int J Dev Biol
Title: Akt1 and insulin-like growth factor 2 (Igf2) regulate placentation and fetal/postnatal development.
Volume: 56
Issue: 4
Pages: 255-61
•
•
•
•
•
Publication
18700973 | J:142118
First Author: Young CD
Year: 2008
Journal: Breast Cancer Res
Title: Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.
Volume: 10
Issue: 4
Pages: R70
•
•
•
•
•
Publication
24106278 | J:204981
First Author: Abdalla M
Year: 2013
Journal: J Biol Chem
Title: Akt1 mediates α-smooth muscle actin expression and myofibroblast differentiation via myocardin and serum response factor.
Volume: 288
Issue: 46
Pages: 33483-93
•
•
•
•
•
Publication
25843685 | J:230544
First Author: Goc A
Year: 2015
Journal: Biochim Biophys Acta
Title: p70 S6-kinase mediates the cooperation between Akt1 and Mek1 pathways in fibroblast-mediated extracellular matrix remodeling.
Volume: 1853
Issue: 7
Pages: 1626-35
•
•
•
•
•
Publication
17012749 | J:117620
First Author: Zhou GL
Year: 2006
Journal: J Biol Chem
Title: Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
Volume: 281
Issue: 47
Pages: 36443-53
•
•
•
•
•
Publication
33030203 | J:298839
First Author: Lindhurst MJ
Year: 2020
Journal: Hum Mol Genet
Title: Ubiquitous expression of Akt1 p.(E17K) results in vascular defects and embryonic lethality in mice.
Volume: 29
Issue: 20
Pages: 3350-3360
•
•
•
•
•
Publication
32937140 | J:306411
First Author: Chen K
Year: 2020
Journal: Cell Rep
Title: Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation.
Volume: 32
Issue: 11
Pages: 108151
•
•
•
•
•
Publication
26190111 | J:232525
First Author: Yu WN
Year: 2015
Journal: Cell Rep
Title: Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration.
Volume: 12
Issue: 4
Pages: 610-21
•
•
•
•
•
Publication
25670795 | J:238888
First Author: Luo W
Year: 2015
Journal: Development
Title: Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.
Volume: 142
Issue: 4
Pages: 732-42
•
•
•
•
•
Publication
16882883 | J:113653
First Author: Schiekofer S
Year: 2006
Journal: Physiol Genomics
Title: Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure.
Volume: 27
Issue: 2
Pages: 156-70
•
•
•
•
•
Publication
21339740 | J:180540
First Author: Kim EK
Year: 2011
Journal: Oncogene
Title: Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Volume: 30
Issue: 26
Pages: 2954-63
•
•
•
•
•
Publication
21532616 | J:177100
First Author: Saji M
Year: 2011
Journal: Oncogene
Title: Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer.
Volume: 30
Issue: 42
Pages: 4307-15
•
•
•
•
•
Publication
23810294 | J:206692
First Author: Gwag T
Year: 2013
Journal: Arch Biochem Biophys
Title: Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.
Volume: 537
Issue: 1
Pages: 21-30
•
•
•
•
•
Publication
19342603 | J:164772
First Author: Symons JD
Year: 2009
Journal: Circ Res
Title: Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Volume: 104
Issue: 9
Pages: 1085-94
•
•
•
•
•
Publication
18336909 | J:134468
First Author: Arranz A
Year: 2008
Journal: Mol Immunol
Title: Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide.
Volume: 45
Issue: 10
Pages: 2970-80
•
•
•
•
•
Publication
23919516 | J:317850
 
First Author: Watson KL
Year: 2013
Journal: BMC Cancer
Title: Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.
Volume: 13
Pages: 375
•
•
•
•
•
Publication
25234814 | J:230474
First Author: Tucka J
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis.
Volume: 34
Issue: 11
Pages: 2421-8
•
•
•
•
•
Publication
12782654 | J:83741
First Author: Peng XD
Year: 2003
Journal: Genes Dev
Title: Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.
Volume: 17
Issue: 11
Pages: 1352-65
•
•
•
•
•
Publication
21312341 | J:241757
First Author: Sinor-Anderson A
Year: 2011
Journal: Dev Neurobiol
Title: Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex.
Volume: 71
Issue: 9
Pages: 759-71
•
•
•
•
•
Publication
11544177 | J:71404
First Author: Chen WS
Year: 2001
Journal: Genes Dev
Title: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.
Volume: 15
Issue: 17
Pages: 2203-8
•
•
•
•
•
Publication
22315412 | J:182010
First Author: Ezell SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Volume: 109
Issue: 10
Pages: E613-21
•
•
•
•
•
Publication
20186153 | J:186366
First Author: Xiao L
Year: 2010
Journal: Cell Death Differ
Title: Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
Volume: 17
Issue: 9
Pages: 1448-62
•
•
•
•
•
Publication
22057724 | J:321353
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
•
•
•
•
•
Publication
36773738 | J:334244
First Author: Kim IY
Year: 2023
Journal: Exp Cell Res
Title: Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition.
Volume: 424
Issue: 2
Pages: 113509
•
•
•
•
•
Publication
33322851 | J:328787
First Author: Kim IY
Year: 2021
Journal: Korean J Intern Med
Title: Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease.
Volume: 36
Issue: 4
Pages: 962-974
•
•
•
•
•
Publication
28911943 | J:257166
 
First Author: Roy R
Year: 2017
Journal: J Mol Cell Cardiol
Title: Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines.
Volume: 112
Pages: 83-90
•
•
•
•
•
Publication
23474853 | J:311783
First Author: Chen YW
Year: 2014
Journal: Schizophr Bull
Title: A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis.
Volume: 40
Issue: 2
Pages: 388-98
•
•
•
•
•
Publication
19762778 | J:167794
First Author: Fernández-Hernando C
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.
Volume: 29
Issue: 12
Pages: 2033-40
•
•
•
•
•
Publication
16923802 | J:117197
First Author: Liu X
Year: 2006
Journal: J Biol Chem
Title: Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.
Volume: 281
Issue: 42
Pages: 31380-8
•
•
•
•
•
Publication
17210696 | J:117336
First Author: Maroulakou IG
Year: 2007
Journal: Cancer Res
Title: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Volume: 67
Issue: 1
Pages: 167-77
•
•
•
•
•
Publication
24126057 | J:206064
First Author: Tsen F
Year: 2013
Journal: Mol Cell Biol
Title: Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo.
Volume: 33
Issue: 24
Pages: 4947-59
•
•
•
•
•
Publication
24583056 | J:231219
 
First Author: Xiong X
Year: 2014
Journal: Neurobiol Dis
Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Volume: 66
Pages: 43-52
•
•
•
•
•
Publication
25931147 | J:223322
First Author: Malla R
Year: 2015
Journal: Biochem Pharmacol
Title: Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
Volume: 96
Issue: 1
Pages: 65-75
•
•
•
•
•
Publication
11590437 | J:72216
First Author: Tuttle RL
Year: 2001
Journal: Nat Med
Title: Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
Volume: 7
Issue: 10
Pages: 1133-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom