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Search results 1 to 100 out of 153 for Tyk2

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Category: Publication
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Type Details Score
Publication
11070174 | J:65409
First Author: Shimoda K
Year: 2000
Journal: Immunity
Title: Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
Volume: 13
Issue: 4
Pages: 561-71
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Publication
27807284 | J:252210
First Author: Dendrou CA
Year: 2016
Journal: Sci Transl Med
Title: Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Volume: 8
Issue: 363
Pages: 363ra149
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Publication
11070173 | J:65408
First Author: Karaghiosoff M
Year: 2000
Journal: Immunity
Title: Partial impairment of cytokine responses in Tyk2-deficient mice.
Volume: 13
Issue: 4
Pages: 549-60
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Publication
32929218 | J:302820
First Author: Poelzl A
Year: 2021
Journal: Cell Death Differ
Title: TYK2 licenses non-canonical inflammasome activation during endotoxemia.
Volume: 28
Issue: 2
Pages: 748-763
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Publication
36185806 | J:333919
First Author: Moritsch S
Year: 2022
Journal: Oncoimmunology
Title: Tyk2 is a tumor suppressor in colorectal cancer.
Volume: 11
Issue: 1
Pages: 2127271
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Publication
21864028 | J:305930
First Author: Zhang Q
Year: 2011
Journal: J Interferon Cytokine Res
Title: The role of Tyk2 in regulation of breast cancer growth.
Volume: 31
Issue: 9
Pages: 671-7
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Publication
24345760 | J:307012
First Author: Ishizaki M
Year: 2014
Journal: Int Immunol
Title: Tyk2 is a therapeutic target for psoriasis-like skin inflammation.
Volume: 26
Issue: 5
Pages: 257-67
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Publication
14768057 | J:87674
First Author: Schleicher U
Year: 2004
Journal: Eur J Immunol
Title: Control of Leishmania major in the absence of Tyk2 kinase.
Volume: 34
Issue: 2
Pages: 519-29
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Publication
18845149 | J:141119
First Author: Schneider A
Year: 2008
Journal: FEBS Lett
Title: Selective contribution of Tyk2 to cell activation by lipopolysaccharide.
Volume: 582
Issue: 25-26
Pages: 3681-6
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Publication
23217260 | J:195099
First Author: Derecka M
Year: 2012
Journal: Cell Metab
Title: Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.
Volume: 16
Issue: 6
Pages: 814-24
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Publication
- | J:66799
   
First Author: McCoy B
Year: 1999
Journal: GenBank Submission
Title: Mus musculus tyrosine kinase TYK2 (Tyk2) mRNA, complete cds
Pages: AF173032
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Publication
12679810 | J:83115
First Author: Karaghiosoff M
Year: 2003
Journal: Nat Immunol
Title: Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock.
Volume: 4
Issue: 5
Pages: 471-7
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Publication
24696087 | J:215350
First Author: Vielnascher RM
Year: 2014
Journal: Transgenic Res
Title: Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
Volume: 23
Issue: 3
Pages: 519-29
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Publication
19494301 | J:149291
First Author: Spach KM
Year: 2009
Journal: J Immunol
Title: A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.
Volume: 182
Issue: 12
Pages: 7776-83
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Publication
25849081 | J:233414
 
First Author: Izumi K
Year: 2015
Journal: Nat Commun
Title: Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.
Volume: 6
Pages: 6748
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Publication
22723949 | J:187818
First Author: Prchal-Murphy M
Year: 2012
Journal: PLoS One
Title: TYK2 kinase activity is required for functional type I interferon responses in vivo.
Volume: 7
Issue: 6
Pages: e39141
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Publication
21765170 | J:176033
First Author: Ishizaki M
Year: 2011
Journal: Int Immunol
Title: Tyk2 deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
Volume: 23
Issue: 9
Pages: 575-82
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Publication
15578097 | J:95477
First Author: Stoiber D
Year: 2004
Journal: J Clin Invest
Title: TYK2 is a key regulator of the surveillance of B lymphoid tumors.
Volume: 114
Issue: 11
Pages: 1650-8
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Publication
32149730 | J:302653
First Author: Gracey E
Year: 2020
Journal: J Clin Invest
Title: TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis.
Volume: 130
Issue: 4
Pages: 1863-1878
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Publication
17048270 | J:117001
First Author: Aizu K
Year: 2006
Journal: Eur J Immunol
Title: An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma.
Volume: 36
Issue: 11
Pages: 3060-70
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Publication
17372006 | J:145141
First Author: Li W
Year: 2007
Journal: J Immunol
Title: Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection.
Volume: 178
Issue: 7
Pages: 4482-8
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Publication
16982690 | J:114648
First Author: Potla R
Year: 2006
Journal: Mol Cell Biol
Title: Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes.
Volume: 26
Issue: 22
Pages: 8562-71
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Publication
20080754 | J:156524
First Author: Bieber AJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.
Volume: 107
Issue: 2
Pages: 792-7
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Publication
30718299 | J:272938
First Author: Simonović N
Year: 2019
Journal: J Immunol
Title: NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
Volume: 202
Issue: 6
Pages: 1724-1734
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Publication
18086385 | J:140278
First Author: Painz R
Year: 2007
Journal: Immunobiology
Title: Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo.
Volume: 212
Issue: 9-10
Pages: 863-75
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Publication
16751369 | J:132232
First Author: Shaw MH
Year: 2006
Journal: J Immunol
Title: Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.
Volume: 176
Issue: 12
Pages: 7263-71
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Publication
14500783 | J:85848
First Author: Shaw MH
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.
Volume: 100
Issue: 20
Pages: 11594-9
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Publication
12391177 | J:79815
First Author: Shimoda K
Year: 2002
Journal: J Immunol
Title: Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
Volume: 169
Issue: 9
Pages: 4707-11
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Publication
17395783 | J:145403
First Author: Tokumasa N
Year: 2007
Journal: Blood
Title: Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation.
Volume: 110
Issue: 2
Pages: 553-60
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Publication
16601124 | J:113742
First Author: Gamero AM
Year: 2006
Journal: J Biol Chem
Title: Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells.
Volume: 281
Issue: 24
Pages: 16238-44
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Publication
21606247 | J:175947
First Author: Ishizaki M
Year: 2011
Journal: J Immunol
Title: Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Volume: 187
Issue: 1
Pages: 181-9
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Publication
27802075 | J:247177
First Author: Raje V
Year: 2017
Journal: Endocrinology
Title: Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.
Volume: 158
Issue: 1
Pages: 148-157
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Publication
30131584 | J:273613
First Author: Prutsch N
Year: 2019
Journal: Leukemia
Title: Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma.
Volume: 33
Issue: 3
Pages: 696-709
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Publication
20338026 | J:307339
 
First Author: Vogl C
Year: 2010
Journal: BMC Genomics
Title: Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.
Volume: 11
Pages: 199
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Publication
12517976 | J:81171
First Author: Seto Y
Year: 2003
Journal: J Immunol
Title: Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.
Volume: 170
Issue: 2
Pages: 1077-83
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Publication
30740104 | J:283092
 
First Author: Gorman JA
Year: 2019
Journal: Front Immunol
Title: The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.
Volume: 10
Pages: 44
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Publication
21787891 | J:309838
First Author: Grunert T
Year: 2011
Journal: J Proteomics
Title: A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C).
Volume: 74
Issue: 12
Pages: 2866-80
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Publication
19917699 | J:157511
First Author: Oyamada A
Year: 2009
Journal: J Immunol
Title: Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis.
Volume: 183
Issue: 11
Pages: 7539-46
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Publication
18641345 | J:139234
First Author: Nakamura R
Year: 2008
Journal: J Immunol
Title: Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells.
Volume: 181
Issue: 3
Pages: 2071-5
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Publication
11877284 | J:115369
First Author: Shimoda K
Year: 2002
Journal: Blood
Title: Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.
Volume: 99
Issue: 6
Pages: 2094-9
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Publication
19118004 | J:143032
First Author: Simma O
Year: 2009
Journal: Cancer Res
Title: Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance.
Volume: 69
Issue: 1
Pages: 203-11
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Publication
14617019 | J:109408
First Author: Kato K
Year: 2003
Journal: Br J Haematol
Title: Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth.
Volume: 123
Issue: 3
Pages: 528-35
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20713887 | J:163818
First Author: Radwan M
Year: 2010
Journal: J Immunol
Title: Tyrosine kinase 2 controls IL-1ß production at the translational level.
Volume: 185
Issue: 6
Pages: 3544-53
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Publication
15226272 | J:91540
First Author: Kamezaki K
Year: 2004
Journal: Int Immunol
Title: The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals.
Volume: 16
Issue: 8
Pages: 1173-9
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Publication
14662340 | J:86970
First Author: Aoki K
Year: 2003
Journal: Exp Hematol
Title: Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
Volume: 31
Issue: 12
Pages: 1317-22
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Publication
29016674 | J:247148
First Author: Wilbers RHP
Year: 2017
Journal: PLoS One
Title: Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain.
Volume: 12
Issue: 10
Pages: e0186317
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Publication
16148148 | J:116703
First Author: Strobl B
Year: 2005
Journal: J Immunol
Title: Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus.
Volume: 175
Issue: 6
Pages: 4000-8
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Publication
24604832 | J:212012
First Author: Bosmann M
Year: 2014
Journal: J Leukoc Biol
Title: Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Volume: 96
Issue: 1
Pages: 123-31
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Publication
15781341 | J:97143
First Author: Ishida N
Year: 2005
Journal: Exp Hematol
Title: Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
Volume: 33
Issue: 4
Pages: 495-503
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25057888 | J:215673
First Author: Babon JJ
Year: 2014
Journal: Biochem J
Title: The molecular regulation of Janus kinase (JAK) activation.
Volume: 462
Issue: 1
Pages: 1-13
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18082134 | J:130706
First Author: Schuster C
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Commentary on H. Ide et al., "Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells".
Volume: 366
Issue: 4
Pages: 869-70
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11313413 | J:69051
First Author: Ortmann R
Year: 2001
Journal: J Immunol
Title: A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.
Volume: 166
Issue: 9
Pages: 5712-9
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Publication
25109392 | J:301701
 
First Author: Übel C
Year: 2014
Journal: Sci Rep
Title: Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.
Volume: 4
Pages: 5865
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24729620 | J:302062
First Author: Hashiguchi T
Year: 2014
Journal: J Immunol
Title: Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against Listeria monocytogenes infection.
Volume: 192
Issue: 10
Pages: 4739-47
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Publication
- | J:66800
   
First Author: Lassnig C
Year: 1998
Journal: GenBank Submission
Title: Mus musculus non-receptor tyrosine kinase (Tyk2) gene, partial cds
Pages: AF052607
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21471442 | J:173100
First Author: Peng DJ
Year: 2011
Journal: J Immunol
Title: Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.
Volume: 186
Issue: 10
Pages: 5638-47
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26824662 | J:230644
First Author: Mostafavi S
Year: 2016
Journal: Cell
Title: Parsing the Interferon Transcriptional Network and Its Disease Associations.
Volume: 164
Issue: 3
Pages: 564-78
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19680139 | J:164174
First Author: Deb C
Year: 2009
Journal: J Neuropathol Exp Neurol
Title: Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.
Volume: 68
Issue: 9
Pages: 1037-48
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11313414 | J:120304
First Author: Yap GS
Year: 2001
Journal: J Immunol
Title: A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment.
Volume: 166
Issue: 9
Pages: 5720-5
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21408089 | J:169918
First Author: Blanc M
Year: 2011
Journal: PLoS Biol
Title: Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.
Volume: 9
Issue: 3
Pages: e1000598
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23836059 | J:205704
First Author: Smith CL
Year: 2013
Journal: J Immunol
Title: IL-22 regulates iron availability in vivo through the induction of hepcidin.
Volume: 191
Issue: 4
Pages: 1845-55
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17785781 | J:152056
First Author: Wesley JD
Year: 2007
Journal: J Immunol
Title: A Y chromosome-linked factor impairs NK T development.
Volume: 179
Issue: 6
Pages: 3480-7
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23653476 | J:197445
First Author: Alazawi W
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.
Volume: 110
Issue: 21
Pages: 8656-61
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15491990 | J:95152
First Author: Gingras S
Year: 2004
Journal: J Biol Chem
Title: Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling.
Volume: 279
Issue: 52
Pages: 54702-7
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12023369 | J:76845
First Author: Parham C
Year: 2002
Journal: J Immunol
Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Volume: 168
Issue: 11
Pages: 5699-708
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8943050 | J:37050
First Author: Presky DH
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
Volume: 93
Issue: 24
Pages: 14002-7
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21878673 | J:178381
First Author: Schuster C
Year: 2011
Journal: Blood
Title: The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.
Volume: 118
Issue: 17
Pages: 4635-45
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18424713 | J:134314
First Author: Wilson DC
Year: 2008
Journal: J Immunol
Title: IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection.
Volume: 180
Issue: 9
Pages: 5935-45
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16482511 | J:320271
First Author: Hoeve MA
Year: 2006
Journal: Eur J Immunol
Title: Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.
Volume: 36
Issue: 3
Pages: 661-70
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11114383 | J:65966
First Author: Oppmann B
Year: 2000
Journal: Immunity
Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Volume: 13
Issue: 5
Pages: 715-25
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19088061 | J:319975
First Author: van de Wetering D
Year: 2009
Journal: Int Immunol
Title: IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12.
Volume: 21
Issue: 2
Pages: 145-53
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24069548 | J:202463
First Author: Li J
Year: 2013
Journal: JAKSTAT
Title: JAK-STAT and bone metabolism.
Volume: 2
Issue: 3
Pages: e23930
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11437454 | J:70363
First Author: Brunskill EW
Year: 2001
Journal: Dev Biol
Title: Novel cell lines promote the discovery of genes involved in early heart development.
Volume: 235
Issue: 2
Pages: 507-20
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22995073 | -
 
First Author: Argiriadi MA
Year: 2012
Journal: BMC Struct Biol
Title: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Volume: 12
Pages: 22
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7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
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32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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15254900 | J:91730
First Author: Verma-Kurvari S
Year: 2004
Journal: Dev Dyn
Title: Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Volume: 230
Issue: 4
Pages: 660-5
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- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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