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Search results 101 to 200 out of 210 for Ahcyl1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3274122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1624622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Note: Expression was detected in the digestive system.
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1646922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1700022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1876522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Note: Expression was weak in the immune system.
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1833322
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1821522
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1756322
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738322
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Specimen Label: MH3314; Specimen C4414
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1768022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Note: Expression was weak in the skull (base and vault).
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309530
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422898
Age: embryonic day 14.5
Image: MH3314; Specimen C4414
Note: Expression was strong in whisker follicle.
Specimen Label: MH3314; Specimen C4414
Detected: true
Specimen Num: 1
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Publication
19224921 | J:149256
First Author: Kiefer H
Year: 2009
Journal: J Biol Chem
Title: Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation.
Volume: 284
Issue: 16
Pages: 10694-705
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Publication
16769890 | J:111036
First Author: Shirakabe K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1).
Volume: 103
Issue: 25
Pages: 9542-7
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Publication
25922519 | J:319100
First Author: Kawaai K
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: IRBIT regulates CaMKIIα activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation.
Volume: 112
Issue: 17
Pages: 5515-20
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Publication
19033647 | J:144738
First Author: Yang D
Year: 2009
Journal: J Clin Invest
Title: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.
Volume: 119
Issue: 1
Pages: 193-202
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Publication
23542070 | J:220505
First Author: Park S
Year: 2013
Journal: Gastroenterology
Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.
Volume: 145
Issue: 1
Pages: 232-41
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Publication
27279487 | J:280286
First Author: He P
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.
Volume: 311
Issue: 2
Pages: F343-51
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Publication
21317537 | J:172037
First Author: Yang D
Year: 2011
Journal: J Clin Invest
Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Volume: 121
Issue: 3
Pages: 956-65
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Publication
- | J:59376
     
First Author: The UK Mouse Genome Centre European Consortium
Year: 2000
Journal: Database Release
Title: European Consortium EST Radiation Hybrid Database
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•
Publication
9371744 | J:44483
First Author: Brady KP
Year: 1997
Journal: Genome Res
Title: Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Volume: 7
Issue: 11
Pages: 1085-93
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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•
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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•
•
Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
16527252 | -
First Author: Devogelaere B
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Binding of IRBIT to the IP3 receptor: determinants and functional effects.
Volume: 343
Issue: 1
Pages: 49-56
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Publication
16793548 | J:111258
First Author: Ando H
Year: 2006
Journal: Mol Cell
Title: IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.
Volume: 22
Issue: 6
Pages: 795-806
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Publication
24518248 | -
First Author: Ando H
Year: 2014
Journal: Biochim Biophys Acta
Title: IRBIT: a regulator of ion channels and ion transporters.
Volume: 1843
Issue: 10
Pages: 2195-204
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Publication
21152975 | -
First Author: Yang D
Year: 2011
Journal: Neurochem Res
Title: IRBIT: it is everywhere.
Volume: 36
Issue: 7
Pages: 1166-74
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Publication
27382360 | -
First Author: Park PW
Year: 2016
Journal: Korean J Physiol Pharmacol
Title: Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association.
Volume: 20
Issue: 4
Pages: 433-40
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Protein Domain
IPR000043 | Adenosylhomocysteinase-like
Type: Family
Description: Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, ) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+ [, , , ].This family also includes S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), also known as IRBIT, and S-adenosylhomocysteine hydrolase-like protein 2 (Ahcyl2). Ahcyl1/IRBIT was shown to interact with inositol 1,4,5-trisphosphate receptors (IP3Rs), which function as intracellular Ca(2+) channels, and suppresses IP3 binding of IP3R [, ]. By competing with IP3, it modulates the threshold IP3 concentration required for the activation of the receptor []. Further studies indicate that Ahcyl1/IRBIT is in fact a multifunctional protein that regulates several ion channels and ion transporters [, ]. Despite its homology to S-adenosylhomocysteine hydrolases, Ahcyl1 has neither enzyme activity nor any effects on the enzyme activity of S-adenosylhomocysteine hydrolase []. Ahcyl2 lacks binding activity to IP3R []. Ahcyl2 upregulates NBCe1-B, which plays an important role in intracellular pH regulation [].
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Protein
A2ALT5
Organism: Mus musculus/domesticus
Length: 95  
Fragment?: true
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Protein
D3Z2Q0
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Protein
F7ATQ6
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
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Protein
A0PJF2
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: true
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Protein
D3YYM7
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Protein
A0A0N4SUY4
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
D3YX97
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
H3BL31
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: true
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Publication
9586999 | -
First Author: Turner MA
Year: 1998
Journal: Nat Struct Biol
Title: Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
Volume: 5
Issue: 5
Pages: 369-76
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Publication
16061414 | -
First Author: Yamada T
Year: 2005
Journal: Int J Biochem Cell Biol
Title: Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Volume: 37
Issue: 11
Pages: 2417-35
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Publication
11325033 | -
First Author: Turner MA
Year: 2000
Journal: Cell Biochem Biophys
Title: Structure and function of S-adenosylhomocysteine hydrolase.
Volume: 33
Issue: 2
Pages: 101-25
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Publication
15165742 | -
First Author: Kloor D
Year: 2004
Journal: Trends Pharmacol Sci
Title: S-Adenosylhomocysteine hydrolase as a target for intracellular adenosine action.
Volume: 25
Issue: 6
Pages: 294-7
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Protein
P50247
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
Q80SW1
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q68FL4
Organism: Mus musculus/domesticus
Length: 613  
Fragment?: false
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Protein
F8WI65
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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