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Search results 101 to 200 out of 2579 for Akt1

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Type Details Score
Publication
First Author: Chen K
Year: 2020
Journal: Cell Rep
Title: Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation.
Volume: 32
Issue: 11
Pages: 108151
Publication
First Author: Luo W
Year: 2015
Journal: Development
Title: Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.
Volume: 142
Issue: 4
Pages: 732-42
Publication
First Author: Schiekofer S
Year: 2006
Journal: Physiol Genomics
Title: Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure.
Volume: 27
Issue: 2
Pages: 156-70
Publication
First Author: Kim EK
Year: 2011
Journal: Oncogene
Title: Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Volume: 30
Issue: 26
Pages: 2954-63
Publication
First Author: Gwag T
Year: 2013
Journal: Arch Biochem Biophys
Title: Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways.
Volume: 537
Issue: 1
Pages: 21-30
Publication
First Author: Saji M
Year: 2011
Journal: Oncogene
Title: Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer.
Volume: 30
Issue: 42
Pages: 4307-15
Publication
First Author: Symons JD
Year: 2009
Journal: Circ Res
Title: Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Volume: 104
Issue: 9
Pages: 1085-94
Publication
First Author: Arranz A
Year: 2008
Journal: Mol Immunol
Title: Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide.
Volume: 45
Issue: 10
Pages: 2970-80
Publication  
First Author: Watson KL
Year: 2013
Journal: BMC Cancer
Title: Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.
Volume: 13
Pages: 375
Publication
First Author: Tucka J
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis.
Volume: 34
Issue: 11
Pages: 2421-8
Publication
First Author: Peng XD
Year: 2003
Journal: Genes Dev
Title: Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.
Volume: 17
Issue: 11
Pages: 1352-65
Publication
First Author: Sinor-Anderson A
Year: 2011
Journal: Dev Neurobiol
Title: Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex.
Volume: 71
Issue: 9
Pages: 759-71
Publication
First Author: Chen WS
Year: 2001
Journal: Genes Dev
Title: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.
Volume: 15
Issue: 17
Pages: 2203-8
Publication
First Author: Ezell SA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY.
Volume: 109
Issue: 10
Pages: E613-21
Publication
First Author: Xiao L
Year: 2010
Journal: Cell Death Differ
Title: Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
Volume: 17
Issue: 9
Pages: 1448-62
Publication
First Author: Zhang Z
Year: 2012
Journal: Mol Cell Biochem
Title: mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos.
Volume: 361
Issue: 1-2
Pages: 249-57
Publication
First Author: Kim IY
Year: 2023
Journal: Exp Cell Res
Title: Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition.
Volume: 424
Issue: 2
Pages: 113509
Publication
First Author: Kim IY
Year: 2021
Journal: Korean J Intern Med
Title: Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease.
Volume: 36
Issue: 4
Pages: 962-974
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
GXD Expression
Probe: MGI:6754112
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-22
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1771322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7287487
Age: embryonic day 14.5
Image: 5D 11Prom-Cre; Sox9; Pten<+/+>
Note: Phosphorylation of Akt1 was reduced in proliferative chondrocytes of 11Prom-Cre; Sox9; Pten<+/+> conditional mutant.
Specimen Label: 5D 11Prom-Cre; Sox9; Pten<+/+>
Detected: true
Specimen Num: 6
Publication  
First Author: Roy R
Year: 2017
Journal: J Mol Cell Cardiol
Title: Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines.
Volume: 112
Pages: 83-90
Publication
First Author: Chen YW
Year: 2014
Journal: Schizophr Bull
Title: A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis.
Volume: 40
Issue: 2
Pages: 388-98
Publication
First Author: Fernández-Hernando C
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.
Volume: 29
Issue: 12
Pages: 2033-40
Publication
First Author: Liu X
Year: 2006
Journal: J Biol Chem
Title: Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.
Volume: 281
Issue: 42
Pages: 31380-8
Publication
First Author: Maroulakou IG
Year: 2007
Journal: Cancer Res
Title: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Volume: 67
Issue: 1
Pages: 167-77
GXD Expression
Probe: MGI:6754112
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1771322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:7287487
Age: embryonic day 14.5
Image: 5D 11Prom-Cre; Sox9; Pten
Note: Phosphorylation levels of Akt1 were higher in the 11Prom-Cre; Sox9; Pten proliferative chondrocytes than in 11Prom-Cre; Sox9; Pten<+/+>.
Specimen Label: 5D 11Prom-Cre; Sox9; Pten
Detected: true
Specimen Num: 7
Publication
First Author: Tsen F
Year: 2013
Journal: Mol Cell Biol
Title: Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo.
Volume: 33
Issue: 24
Pages: 4947-59
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
UniProt Feature
Begin: 1
Description: Proline-rich AKT1 substrate 1
Type: chain
End: 257
Gene
Type: gene
Organism: frog, western clawed
Publication  
First Author: Xiong X
Year: 2014
Journal: Neurobiol Dis
Title: PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.
Volume: 66
Pages: 43-52
Publication
First Author: Malla R
Year: 2015
Journal: Biochem Pharmacol
Title: Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
Volume: 96
Issue: 1
Pages: 65-75
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
Publication
First Author: Tuttle RL
Year: 2001
Journal: Nat Med
Title: Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
Volume: 7
Issue: 10
Pages: 1133-7
Publication
First Author: Kobayashi H
Year: 2010
Journal: Nat Cell Biol
Title: Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.
Volume: 12
Issue: 11
Pages: 1046-56
Publication
First Author: Cho H
Year: 2001
Journal: J Biol Chem
Title: Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Volume: 276
Issue: 42
Pages: 38349-52
Publication
First Author: Feng Q
Year: 2010
Journal: Mol Cell Biol
Title: PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Volume: 30
Issue: 14
Pages: 3711-21
Protein Domain
Type: Family
Description: Proline-rich AKT1 substrate 1 protein (AKT1S1, PRAS40) is part of the mammalian target of rapamycin complex 1 (mTORC1, contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR), which regulates cell growth and survival in response to nutrient and hormonal signals []. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection [, ].
Publication
First Author: Wang CY
Year: 2009
Journal: Sci Signal
Title: Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
Volume: 2
Issue: 62
Pages: ra11
Publication
First Author: Ha T
Year: 2005
Journal: Free Radic Biol Med
Title: Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
Volume: 39
Issue: 12
Pages: 1570-80
Publication
First Author: Matsui T
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Effects of chronic Akt activation on glucose uptake in the heart.
Volume: 290
Issue: 5
Pages: E789-97
Publication
First Author: Mukai Y
Year: 2006
Journal: J Clin Invest
Title: Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
Volume: 116
Issue: 2
Pages: 334-43
Publication
First Author: Blandino-Rosano M
Year: 2012
Journal: Diabetologia
Title: Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip.
Volume: 55
Issue: 5
Pages: 1380-9
Publication      
First Author: Cordón-Barris L
Year: 2016
Journal: Mol Cell Biol
Title: Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.
Publication
First Author: Zurashvili T
Year: 2013
Journal: Mol Cell Biol
Title: Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
Volume: 33
Issue: 5
Pages: 1027-40
Publication
First Author: Sun JF
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Microvascular patterning is controlled by fine-tuning the Akt signal.
Volume: 102
Issue: 1
Pages: 128-33
Publication
First Author: Wende AR
Year: 2015
Journal: Mol Cell Biol
Title: Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.
Volume: 35
Issue: 5
Pages: 831-46
Publication
First Author: Hutchinson J
Year: 2001
Journal: Mol Cell Biol
Title: Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.
Volume: 21
Issue: 6
Pages: 2203-12
Publication
First Author: Matsui T
Year: 2002
Journal: J Biol Chem
Title: Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.
Volume: 277
Issue: 25
Pages: 22896-901
Publication
First Author: Mao C
Year: 2007
Journal: J Immunol
Title: Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Volume: 178
Issue: 9
Pages: 5443-53
Publication
First Author: Jones RG
Year: 2000
Journal: J Exp Med
Title: Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo.
Volume: 191
Issue: 10
Pages: 1721-34
Publication
First Author: Phung TL
Year: 2006
Journal: Cancer Cell
Title: Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Volume: 10
Issue: 2
Pages: 159-70
Gene
Type: gene
Organism: frog, African clawed
Gene
Type: gene
Organism: frog, African clawed
Publication    
First Author: Figlia G
Year: 2017
Journal: Elife
Title: Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.
Volume: 6
Publication
First Author: Shioi T
Year: 2002
Journal: Mol Cell Biol
Title: Akt/protein kinase B promotes organ growth in transgenic mice.
Volume: 22
Issue: 8
Pages: 2799-809
Publication
First Author: Elghazi L
Year: 2009
Journal: Gastroenterology
Title: Regulation of pancreas plasticity and malignant transformation by Akt signaling.
Volume: 136
Issue: 3
Pages: 1091-103
Publication
First Author: Izumiya Y
Year: 2008
Journal: Cell Metab
Title: Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.
Volume: 7
Issue: 2
Pages: 159-72
Publication
First Author: Emamian ES
Year: 2004
Journal: Nat Genet
Title: Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Volume: 36
Issue: 2
Pages: 131-7
Publication
First Author: Jee HJ
Year: 2009
Journal: Biochem Biophys Res Commun
Title: UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS.
Volume: 383
Issue: 3
Pages: 358-62
Publication
First Author: Zemanovic S
Year: 2018
Journal: Cell Rep
Title: Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance.
Volume: 25
Issue: 9
Pages: 2605-2616.e7
Publication
First Author: Lee MY
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.
Volume: 38
Issue: 4
Pages: 870-879
Publication
First Author: Guo J
Year: 2019
Journal: Nat Cell Biol
Title: AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.
Volume: 21
Issue: 2
Pages: 226-237
Publication
First Author: Riol-Blanco L
Year: 2009
Journal: Nat Immunol
Title: Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells.
Volume: 10
Issue: 7
Pages: 753-60
Publication
First Author: Wang L
Year: 2015
Journal: Blood
Title: Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.
Volume: 126
Issue: 5
Pages: 640-50
Publication
First Author: Luckey SW
Year: 2009
Journal: J Mol Cell Cardiol
Title: The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.
Volume: 46
Issue: 5
Pages: 739-47
Publication
First Author: Skeen JE
Year: 2006
Journal: Cancer Cell
Title: Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
Volume: 10
Issue: 4
Pages: 269-80
Publication
First Author: Schleicher M
Year: 2009
Journal: Sci Signal
Title: The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo.
Volume: 2
Issue: 82
Pages: ra41
Publication
First Author: Shearin AL
Year: 2016
Journal: Mol Metab
Title: Lack of AKT in adipocytes causes severe lipodystrophy.
Volume: 5
Issue: 7
Pages: 472-479
Publication
First Author: Yasui T
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.
Volume: 109
Issue: 51
Pages: 21022-7
Publication
First Author: Lin Y
Year: 2012
Journal: Mol Cell
Title: Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells.
Volume: 48
Issue: 4
Pages: 627-40
Publication  
First Author: Kerr BA
Year: 2016
Journal: Nat Commun
Title: Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.
Volume: 7
Pages: 10960
Publication    
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
Publication  
First Author: Gao F
Year: 2017
Journal: Cancer Lett
Title: Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis.
Volume: 402
Pages: 177-189
Publication
First Author: Segrelles C
Year: 2007
Journal: Cancer Res
Title: Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Volume: 67
Issue: 22
Pages: 10879-88
Publication
First Author: Brown C
Year: 2010
Journal: Biol Reprod
Title: Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.
Volume: 82
Issue: 2
Pages: 246-56
Publication
First Author: Rogers R
Year: 2008
Journal: Toxicol Sci
Title: Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis.
Volume: 106
Issue: 2
Pages: 497-508
Publication
First Author: Luo DZ
Year: 2020
Journal: Sci Rep
Title: Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models.
Volume: 10
Issue: 1
Pages: 647
Publication
First Author: Yung HW
Year: 2008
Journal: Am J Pathol
Title: Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.
Volume: 173
Issue: 2
Pages: 451-62
Publication
First Author: Akasaki Y
Year: 2014
Journal: Aging Cell
Title: Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism.
Volume: 13
Issue: 1
Pages: 80-91
Publication
First Author: Hauge H
Year: 2009
Journal: Cell Signal
Title: Evidence for the involvement of FAM110C protein in cell spreading and migration.
Volume: 21
Issue: 12
Pages: 1866-73
Publication
First Author: Guha M
Year: 2010
Journal: Mol Biol Cell
Title: Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.
Volume: 21
Issue: 20
Pages: 3578-89
Publication
First Author: Singh S
Year: 2016
Journal: Stem Cells
Title: AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication.
Volume: 34
Issue: 9
Pages: 2354-67
Publication  
First Author: Blaustein M
Year: 2021
Journal: Front Cell Dev Biol
Title: Akt Is S-Palmitoylated: A New Layer of Regulation for Akt.
Volume: 9
Pages: 626404
Publication
First Author: Hanatani S
Year: 2014
Journal: J Am Soc Nephrol
Title: Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease.
Volume: 25
Issue: 12
Pages: 2800-11
Publication  
First Author: Guo SL
Year: 2013
Journal: Nat Commun
Title: Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency.
Volume: 4
Pages: 2544
Publication
First Author: Wang Q
Year: 2016
Journal: Cancer Cell
Title: Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.
Volume: 29
Issue: 4
Pages: 523-535
Publication    
First Author: Levenga J
Year: 2017
Journal: Elife
Title: AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity.
Volume: 6
Publication
First Author: Ren B
Year: 2010
Journal: J Clin Invest
Title: ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
Volume: 120
Issue: 4
Pages: 1217-28
Publication
First Author: Fang L
Year: 2014
Journal: Mol Cell
Title: A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.
Volume: 55
Issue: 4
Pages: 537-51
Publication
First Author: Chen M
Year: 2023
Journal: Cell Rep
Title: Identification of XAF1 as an endogenous AKT inhibitor.
Volume: 42
Issue: 7
Pages: 112690
Publication    
First Author: Wong H
Year: 2020
Journal: Elife
Title: Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders.
Volume: 9
Publication
First Author: Ding L
Year: 2012
Journal: Cell Metab
Title: Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Volume: 15
Issue: 6
Pages: 861-72
Publication
First Author: Matheny RW Jr
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.
Volume: 389
Issue: 1
Pages: 117-21
Publication
First Author: Larson-Casey JL
Year: 2021
Journal: FASEB J
Title: Post-translational regulation of PGC-1α modulates fibrotic repair.
Volume: 35
Issue: 6
Pages: e21675