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Search results 101 to 200 out of 215 for Ccs

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Type Details Score
Author
Chini CCS
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Author
Caetano CCS
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Publication
17389365 | J:120361
First Author: Son M
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology.
Volume: 104
Issue: 14
Pages: 6072-7
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GO Term
GO:0052727 | capsanthin synthase activity
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Publication
21354101 | J:177899
First Author: Kim HK
Year: 2011
Journal: Arch Biochem Biophys
Title: Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: implication of a free radical hypothesis.
Volume: 509
Issue: 2
Pages: 177-85
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Publication
29467757 | J:335746
 
First Author: Sohrabi Y
Year: 2018
Journal: Front Immunol
Title: Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice.
Volume: 9
Pages: 130
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GO Term
GO:0052728 | capsorubin synthase activity
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HT Experiment
GSE231547 | Transcriptomic profiling of the postnatal mouse cardiac conduction system
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Col1a1<tm1(tetO-EWSR1/ATF1)Yasu> | MGI:5485192
Name: collagen, type I, alpha 1; targeted mutation 1, Yasuhiro Yamada
Allele Type: Targeted
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, RMCE-ready
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Allele
Gt(ROSA)26Sor<tm1(EWSR1/ATF1)Yasu> | MGI:6386674
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Yasuhiro Yamada
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Col1a1<tm2(tetO-EWSR1/ATF1,-mCherry)Yasu> | MGI:6470985
Name: collagen, type I, alpha 1; targeted mutation 2, Yasuhiro Yamada
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence
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Publication
27304511 | J:251832
First Author: Camacho-Pereira J
Year: 2016
Journal: Cell Metab
Title: CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Volume: 23
Issue: 6
Pages: 1127-1139
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Publication
35600581 | J:325688
 
First Author: Meyer-Ficca ML
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Low NAD+ Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice.
Volume: 13
Pages: 896356
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Publication
35114253 | J:321546
 
First Author: Agorrody G
Year: 2022
Journal: J Mol Cell Cardiol
Title: Benefits in cardiac function by CD38 suppression: Improvement in NAD+ levels, exercise capacity, heart rate variability and protection against catecholamine-induced ventricular arrhythmias.
Volume: 166
Pages: 11-22
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Publication
34493542 | J:333022
First Author: Langley MR
Year: 2021
Journal: J Neurosci
Title: Critical Role of Astrocyte NAD(+) Glycohydrolase in Myelin Injury and Regeneration.
Volume: 41
Issue: 41
Pages: 8644-8667
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HT Experiment
GSE132658 | Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Strain
MGI:6474563 | B6;129S4-Gt(ROSA)26Sor<tm1(EWSR1/ATF1)Yasu>/YasuRbrc
Attribute String: targeted mutation, mutant stock
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Publication
29719225 | J:263029
First Author: Tarragó MG
Year: 2018
Journal: Cell Metab
Title: A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.
Volume: 27
Issue: 5
Pages: 1081-1095.e10
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Publication
38838044 | J:349921
First Author: de Sá KSG
Year: 2024
Journal: PLoS Pathog
Title: Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19.
Volume: 20
Issue: 6
Pages: e1012222
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HT Experiment
E-GEOD-46906 | Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
Series Id: GSE46906
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
31488818 | J:279289
First Author: Komura S
Year: 2019
Journal: Nat Commun
Title: Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas.
Volume: 10
Issue: 1
Pages: 3999
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Protein
Q8BHG2
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
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Protein
B7ZC71
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
A2A8E4
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
D6REH4
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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Protein
A2A8E2
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: false
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Protein
B7ZC72
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
B7ZC73
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Publication
30260988 | -
First Author: Furukawa Y
Year: 2018
Journal: PLoS One
Title: Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain.
Volume: 13
Issue: 9
Pages: e0204355
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Protein Domain
IPR008584 | CXXC_Zn-binding_euk
Type: Family
Description: This family consists of a number of eukaryotic proteins including CXXC motif containing zinc binding protein (previously known as UPF0587 protein C1orf123). The crystal structure reveals that the protein binds a Zn2+ ion in a tetrahedral coordination with four Cys residues from two CxxC motifs. CXXC motif containing zinc binding protein was initially identified as an interaction partner for the heavy metal-associated (HMA) domain of CCS (copper chaperone for superoxide dismutase). However, it was shown that only misfolded mutant forms, lacking part of the zinc-binding sites, interact with CCS [].
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Publication
35298089 | J:327511
First Author: de Zélicourt A
Year: 2022
Journal: EMBO Mol Med
Title: CD38-NADase is a new major contributor to Duchenne muscular dystrophic phenotype.
Volume: 14
Issue: 5
Pages: e12860
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Publication
36388973 | J:352989
First Author: Zeidler JD
Year: 2022
Journal: iScience
Title: Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide).
Volume: 25
Issue: 11
Pages: 105431
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Publication
33385109 | J:309304
First Author: Shi B
Year: 2021
Journal: iScience
Title: Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis.
Volume: 24
Issue: 1
Pages: 101902
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Publication
36103544 | J:331763
First Author: de Almeida L
Year: 2022
Journal: Sci Adv
Title: Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
Volume: 8
Issue: 37
Pages: eabo5400
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Publication
36763010 | J:354780
First Author: Rodrigues TS
Year: 2023
Journal: J Infect Dis
Title: CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation.
Volume: 227
Issue: 12
Pages: 1364-1375
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HT Experiment
GSE230531 | Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
E-MTAB-14442 | Single nuclei RNA-seq and snATAC-seq multiome performed in WT and Dhx36 conditional KO hearts at postnatal day 7 (PD7)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
23281395 | J:194505
First Author: Yamada K
Year: 2013
Journal: J Clin Invest
Title: EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice.
Volume: 123
Issue: 2
Pages: 600-10
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Strain
MGI:6474578 | B6;129S4-Gt(ROSA)26Sor<tm2(rtTA3,-Venus)Yasu> Col1a1<tm2(tetO-EWSR1/ATF1,-mCherry)Yasu>/YasuRbrc
Attribute String: targeted mutation, mutant stock
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Protein Domain
IPR046803 | DNAPKcs_CC1-2
Type: Domain
Description: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ) which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. It folds into three well-defined large structural units, consisting of a N-terminal region, the Circular Cradle (consisting of five supersecondary α-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This entry represents CC1 and CC2, which contain the Highly conserved region I (HCR-I) [, , , ].
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Strain
MGI:6474532 | B6;129S4-Gt(ROSA)26Sor<tm1(rtTA*M2)Jae> Col1a1<tm2(tetO-EWSR1/ATF1,-mCherry)Yasu>/YasuRbrc
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
26786210 | J:229006
First Author: van Weerd JH
Year: 2016
Journal: Development
Title: The formation and function of the cardiac conduction system.
Volume: 143
Issue: 2
Pages: 197-210
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Protein Domain
IPR012582 | DNAPKcs_CC3
Type: Domain
Description: This domain represents a region of the Circular Cradle segment (CC) from DNA-PKcs that covers the complete CC3 and part of CC4. This domain contains the Ku-binding site A and a the highly conserved region (HCR) II [].DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ), which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. DNA-PKcs phosphorylates a number of protein substrates, including the heat shock protein 90 (HSP90), the transcription factors p53, specificity protein 1 (Sp1) and MYC23, and a majority of NHEJ factors. It folds into three well-defined large structural units, consisting of a N-terminal region (arranged in four supersecondary α-helical structures, N1 to N4), the Circular Cradle (consisting of five supersecondary α-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The N-terminal region likely mediates DNA binding and, together with the CCs, forms a ring through which Ku70/80 may present DNA for repair. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. It has been suggested that the binding of Ku or DNA activates the allosteric mechanism required for communication between the N terminus and the CC with the kinase in the Head [, , , ].
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Protein Domain
IPR045581 | DNAPKcs_CC5
Type: Domain
Description: This entry represents the C-terminal region of the Circular Cradle segment (CC) of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), containing most of the supersecondary structure CC4 and the complete CC5. Structural studies revealed that this domain contains the Ku-binding site B and one of the caspase-3 cleavage sites [].DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ), which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. DNA-PKcs phosphorylates a number of protein substrates, including the heat shock protein 90 (HSP90), the transcription factors p53, specificity protein 1 (Sp1) and MYC23, and a majority of NHEJ factors. It folds into three well-defined large structural units, consisting of a N-terminal region (arranged in four supersecondary α-helical structures, N1 to N4), the Circular Cradle (consisting of five supersecondary α-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The N-terminal region likely mediates DNA binding and, together with the CCs, forms a ring through which Ku70/80 may present DNA for repair. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. It has been suggested that the binding of Ku or DNA activates the allosteric mechanism required for communication between the N terminus and the CC with the kinase in the Head [, , , ].
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mpz-cre)94Imeg/?
Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
28840859 | -
First Author: Yin X
Year: 2017
Journal: Cell Res
Title: Cryo-EM structure of human DNA-PK holoenzyme.
Volume: 27
Issue: 11
Pages: 1341-1350
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Publication
28154079 | -
First Author: Sibanda BL
Year: 2017
Journal: Science
Title: DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Volume: 355
Issue: 6324
Pages: 520-524
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Publication
28652322 | -
First Author: Sharif H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Cryo-EM structure of the DNA-PK holoenzyme.
Volume: 114
Issue: 28
Pages: 7367-7372
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Publication
33077952 | -
First Author: Chaplin AK
Year: 2021
Journal: Nat Struct Mol Biol
Title: Dimers of DNA-PK create a stage for DNA double-strand break repair.
Volume: 28
Issue: 1
Pages: 13-19
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Publication
21504046 | J:178662
First Author: Arnolds DE
Year: 2011
Journal: Genesis
Title: Inducible recombination in the cardiac conduction system of minK: CreERT² BAC transgenic mice.
Volume: 49
Issue: 11
Pages: 878-84
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Publication
15790958 | J:108531
First Author: Ismat FA
Year: 2005
Journal: Circ Res
Title: Homeobox protein Hop functions in the adult cardiac conduction system.
Volume: 96
Issue: 8
Pages: 898-903
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HT Experiment
GSE67013 | Cyclodextrin promotes atherosclerosis regression via LXR activation (II)
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H2az2/H2az2<+> Tg(CAG-cat,-lacZ)11Miya/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Publication
23410975 | J:194308
First Author: Straessler KM
Year: 2013
Journal: Cancer Cell
Title: Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.
Volume: 23
Issue: 2
Pages: 215-27
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Publication
39182223 | J:354988
First Author: Lingamallu SM
Year: 2024
Journal: Cell Rep
Title: Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition.
Volume: 43
Issue: 9
Pages: 114654
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Publication
31620676 | J:287464
First Author: Grüneboom A
Year: 2019
Journal: Nat Metab
Title: A network of trans-cortical capillaries as mainstay for blood circulation in long bones.
Volume: 1
Issue: 2
Pages: 236-250
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Publication
15248063 | J:154017
First Author: Poelmann RE
Year: 2004
Journal: Anat Embryol (Berl)
Title: The neural crest is contiguous with the cardiac conduction system in the mouse embryo: a role in induction?
Volume: 208
Issue: 5
Pages: 389-93
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Publication
39366945 | J:355142
First Author: Gómez-Del Arco P
Year: 2024
Journal: Nat Commun
Title: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
Volume: 15
Issue: 1
Pages: 8602
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Publication
39095365 | J:357277
First Author: Oh Y
Year: 2024
Journal: Nat Commun
Title: Transcriptional regulation of the postnatal cardiac conduction system heterogeneity.
Volume: 15
Issue: 1
Pages: 6550
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Publication
28402849 | J:251486
First Author: Guha A
Year: 2017
Journal: Cell Rep
Title: Uroplakin 3a+ Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.
Volume: 19
Issue: 2
Pages: 246-254
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Publication
35578131 | J:349183
First Author: Osorno T
Year: 2022
Journal: Nat Neurosci
Title: Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties.
Volume: 25
Issue: 6
Pages: 702-713
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Publication
3237805 | J:28845
First Author: Pauly JR
Year: 1988
Journal: Physiol Behav
Title: Adrenocortical hormone regulation of nicotine sensitivity in mice.
Volume: 44
Issue: 1
Pages: 109-16
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Publication
25083869 | J:214605
First Author: Tschaharganeh DF
Year: 2014
Journal: Cell
Title: p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.
Volume: 158
Issue: 3
Pages: 579-92
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Publication
37666871 | J:356216
First Author: Ren H
Year: 2023
Journal: Sci Data
Title: Single-cell RNA sequencing of murine hearts for studying the development of the cardiac conduction system.
Volume: 10
Issue: 1
Pages: 577
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Publication
21527826 | J:173689
First Author: Gutiérrez-Caballero C
Year: 2011
Journal: Cell Cycle
Title: Identification and molecular characterization of the mammalian α-kleisin RAD21L.
Volume: 10
Issue: 9
Pages: 1477-87
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Publication
35613877 | J:354175
First Author: Ueda Y
Year: 2022
Journal: Exp Anim
Title: Possible testosterone redundancy for 5α-dihydrotestosterone in the masculinization of mouse external genitalia.
Volume: 71
Issue: 4
Pages: 451-459
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Publication
22728936 | J:190765
First Author: Arnolds DE
Year: 2012
Journal: J Clin Invest
Title: TBX5 drives Scn5a expression to regulate cardiac conduction system function.
Volume: 122
Issue: 7
Pages: 2509-18
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Publication
24281837 | J:207828
First Author: Wu M
Year: 2014
Journal: Genesis
Title: Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.
Volume: 52
Issue: 2
Pages: 134-40
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Publication
25689248 | J:220541
First Author: Boulter L
Year: 2015
Journal: J Clin Invest
Title: WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Volume: 125
Issue: 3
Pages: 1269-85
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Publication
8944029 | J:36996
First Author: van Wezel T
Year: 1996
Journal: Nat Genet
Title: Gene interaction and single gene effects in colon tumour susceptibility in mice.
Volume: 14
Issue: 4
Pages: 468-70
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Publication
16767220 | J:111718
First Author: Xu X
Year: 2006
Journal: J Clin Invest
Title: Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.
Volume: 116
Issue: 7
Pages: 1843-52
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Publication
25267913 | J:225860
First Author: Martinez-Espinosa PL
Year: 2014
Journal: J Gen Physiol
Title: Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.
Volume: 144
Issue: 4
Pages: 275-95
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Publication
11741389 | J:119899
First Author: Watanabe M
Year: 2001
Journal: Neurobiol Dis
Title: Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.
Volume: 8
Issue: 6
Pages: 933-41
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Publication
26826269 | J:230865
 
First Author: Williams JR
Year: 2016
Journal: Neurobiol Dis
Title: Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD.
Volume: 89
Pages: 1-9
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Publication
24687990 | J:216531
First Author: Hartman ME
Year: 2014
Journal: FASEB J
Title: Myocardial deletion of transcription factor CHF1/Hey2 results in altered myocyte action potential and mild conduction system expansion but does not alter conduction system function or promote spontaneous arrhythmias.
Volume: 28
Issue: 7
Pages: 3007-15
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Publication
25855670 | J:222623
First Author: Ploutarchou P
Year: 2015
Journal: Reproduction
Title: Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes.
Volume: 149
Issue: 5
Pages: 533-43
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Publication
17459410 | J:122305
First Author: Viswanathan S
Year: 2007
Journal: J Mol Cell Cardiol
Title: Characterization of sinoatrial node in four conduction system marker mice.
Volume: 42
Issue: 5
Pages: 946-53
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Publication
28358866 | J:247134
First Author: Bhattacharyya S
Year: 2017
Journal: PLoS One
Title: Phenotypically silent Cre recombination within the postnatal ventricular conduction system.
Volume: 12
Issue: 3
Pages: e0174517
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Publication
30042181 | J:266576
 
First Author: Mohan RA
Year: 2018
Journal: Development
Title: Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction.
Volume: 145
Issue: 17
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Publication
38700011 | J:352366
First Author: Lin HB
Year: 2024
Journal: J Am Heart Assoc
Title: Monocyte-Derived Macrophages Aggravate Cardiac Dysfunction After Ischemic Stroke in Mice.
Volume: 13
Issue: 9
Pages: e034731
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Publication
20110552 | J:245052
First Author: Pallante BA
Year: 2010
Journal: Circ Arrhythm Electrophysiol
Title: Contactin-2 expression in the cardiac Purkinje fiber network.
Volume: 3
Issue: 2
Pages: 186-94
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Publication
33737326 | J:305402
 
First Author: Biosse Duplan M
Year: 2021
Journal: Dis Model Mech
Title: An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton.
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Protein
P97313
Organism: Mus musculus/domesticus
Length: 4128  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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