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Search results 101 to 200 out of 364 for Cul1

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10314
Specimen Label: GUDMAP:10314
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2769723
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2852723
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2845723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1796223
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5002306
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2854023
Stage: TS23
Assay Id: MGI:5542860
Age: embryonic day 15.5
Image: GUDMAP:10315
Specimen Label: GUDMAP:10315
Detected: false
Specimen Num: 2
•
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:948559
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540656
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
•
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•
GXD Expression
GXD Expression
   
Probe: MGI:948559
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540656
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:948559
Assay Type: RNA in situ
Annotation Date: 2023-10-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7540656
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
20832730 | J:163988
First Author: Gao D
Year: 2010
Journal: Mol Cell
Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
Volume: 39
Issue: 5
Pages: 797-808
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Publication
12140560 | J:163142
First Author: Yoshida Y
Year: 2002
Journal: Nature
Title: E3 ubiquitin ligase that recognizes sugar chains.
Volume: 418
Issue: 6896
Pages: 438-42
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Publication
12665572 | J:82741
First Author: Tokuzawa Y
Year: 2003
Journal: Mol Cell Biol
Title: Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development.
Volume: 23
Issue: 8
Pages: 2699-708
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Publication
20937703 | J:166065
First Author: Flomerfelt FA
Year: 2010
Journal: J Exp Med
Title: Tbata modulates thymic stromal cell proliferation and thymus function.
Volume: 207
Issue: 11
Pages: 2521-32
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Publication
26418746 | J:269474
   
First Author: McCormack RM
Year: 2015
Journal: Elife
Title: Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2.
Volume: 4
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Publication
18826954 | J:143467
First Author: Kim AY
Year: 2008
Journal: J Biol Chem
Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Volume: 283
Issue: 48
Pages: 33211-20
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Publication
18929646 | J:228114
First Author: Seo E
Year: 2009
Journal: Cell Signal
Title: Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling.
Volume: 21
Issue: 1
Pages: 43-51
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Publication
10097128 | J:54020
First Author: Hatakeyama S
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Volume: 96
Issue: 7
Pages: 3859-63
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Publication
11735228 | J:73276
First Author: Maruyama S
Year: 2001
Journal: Genomics
Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
Volume: 78
Issue: 3
Pages: 214-22
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Publication
23452856 | J:196293
First Author: Hirano A
Year: 2013
Journal: Cell
Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
Volume: 152
Issue: 5
Pages: 1106-18
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Publication
17290223 | J:120099
First Author: Nemajerova A
Year: 2007
Journal: EMBO J
Title: Impaired DNA damage checkpoint response in MIF-deficient mice.
Volume: 26
Issue: 4
Pages: 987-97
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Publication
32937135 | J:298890
First Author: Wirianto M
Year: 2020
Journal: Cell Rep
Title: The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.
Volume: 32
Issue: 11
Pages: 108140
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Publication
17636028 | J:125326
First Author: Tian Y
Year: 2007
Journal: Mol Cell Biol
Title: TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.
Volume: 27
Issue: 18
Pages: 6383-95
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Publication
25670854 | J:278427
First Author: Nakajima T
Year: 2015
Journal: J Biol Chem
Title: Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.
Volume: 290
Issue: 16
Pages: 10368-81
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Publication
15456869 | J:93325
First Author: Huang Z
Year: 2004
Journal: Mol Cell Biol
Title: Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.
Volume: 24
Issue: 20
Pages: 8951-62
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Publication
21343341 | J:172833
First Author: Chen BB
Year: 2011
Journal: Mol Cell Biol
Title: Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis.
Volume: 31
Issue: 9
Pages: 1905-20
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Publication
21368834 | J:170812
First Author: Wertz IE
Year: 2011
Journal: Nature
Title: Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Volume: 471
Issue: 7336
Pages: 110-4
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Publication
23868976 | J:210401
First Author: Swarnalatha M
Year: 2013
Journal: J Cell Sci
Title: Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment.
Volume: 126
Issue: Pt 20
Pages: 4636-46
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Publication
17803915 | J:127941
First Author: Yao I
Year: 2007
Journal: Cell
Title: SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release.
Volume: 130
Issue: 5
Pages: 943-57
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Publication
29593216 | J:259707
First Author: Ye B
Year: 2018
Journal: Nat Commun
Title: Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.
Volume: 9
Issue: 1
Pages: 1261
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Publication
22405651 | J:184206
First Author: Tron AE
Year: 2012
Journal: Mol Cell
Title: The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
Volume: 46
Issue: 1
Pages: 67-78
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Publication
26471094 | J:226978
First Author: Tateossian H
Year: 2015
Journal: Dis Model Mech
Title: Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
Volume: 8
Issue: 12
Pages: 1531-42
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Publication
32232159 | J:289957
First Author: Guan Y
Year: 2020
Journal: Sci Adv
Title: SKP1 drives the prophase I to metaphase I transition during male meiosis.
Volume: 6
Issue: 13
Pages: eaaz2129
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Publication
29472293 | J:262785
First Author: Nakayama S
Year: 2018
Journal: J Biol Chem
Title: Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3.
Volume: 293
Issue: 15
Pages: 5705-5714
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Publication
33020269 | J:299730
First Author: Zhang L
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling.
Volume: 117
Issue: 42
Pages: 26448-26459
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
19521500 | J:149737
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
12504026 | -
First Author: Zheng J
Year: 2002
Journal: Mol Cell
Title: CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Volume: 10
Issue: 6
Pages: 1519-26
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Publication
12504025 | -
First Author: Liu J
Year: 2002
Journal: Mol Cell
Title: NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
Volume: 10
Issue: 6
Pages: 1511-8
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Allele
Cul1<em1Smoc> | MGI:7289205
Name: cullin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Tg(Cd4-CUL1-N252)1Ingh | MGI:2447878
Name: transgene insertion 1, Giorgio Inghirami
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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GO Term
GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex
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Publication
11961546 | J:76096
First Author: Zheng N
Year: 2002
Journal: Nature
Title: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Volume: 416
Issue: 6882
Pages: 703-9
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GO Term
GO:0019005 | SCF ubiquitin ligase complex
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GO Term
GO:0043223 | cytoplasmic SCF ubiquitin ligase complex
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GO Term
GO:0043224 | nuclear SCF ubiquitin ligase complex
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Publication
18094723 | J:132195
First Author: Welcker M
Year: 2008
Journal: Nat Rev Cancer
Title: FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Volume: 8
Issue: 2
Pages: 83-93
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Protein Coding Gene
MGI:1891471 | Spsb3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444450 | Fbxl18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354697 | Fbxl8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2443262 | Fbxl9
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12904573 | J:85161
First Author: Arai T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.
Volume: 100
Issue: 17
Pages: 9855-60
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Publication
20935640 | J:166928
First Author: Hoeck JD
Year: 2010
Journal: Nat Neurosci
Title: Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
Volume: 13
Issue: 11
Pages: 1365-72
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Publication
25970626 | J:235324
First Author: Sjögren B
Year: 2015
Journal: PLoS One
Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Volume: 10
Issue: 5
Pages: e0123581
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Publication
12759363 | J:84722
First Author: Wu K
Year: 2003
Journal: J Biol Chem
Title: DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
Volume: 278
Issue: 31
Pages: 28882-91
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Publication
12424201 | J:82127
First Author: Chiarle R
Year: 2003
Journal: Blood
Title: NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.
Volume: 101
Issue: 5
Pages: 1919-27
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Publication
12609982 | -
First Author: Min KW
Year: 2003
Journal: J Biol Chem
Title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
Volume: 278
Issue: 18
Pages: 15905-10
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Publication
16449638 | -
First Author: Lo SC
Year: 2006
Journal: Mol Cell Biol
Title: CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
Volume: 26
Issue: 4
Pages: 1235-44
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Publication
23453757 | -
First Author: Pierce NW
Year: 2013
Journal: Cell
Title: Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.
Volume: 153
Issue: 1
Pages: 206-15
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Protein Domain
IPR039852 | CAND1/CAND2
Type: Family
Description: This entry includes cullin-associated NEDD8-dissociated proteins 1 (CAND1 also known as TIP120A) and 2 (CAND2); these proteins have a C-terminal TATA-binding protein interacting (TIP20) domain. CAND1 is required for the assembly of the SCF E3 ubiquitin ligase complex. The SCF ubiquitin E3 ligase consists of SKP1, CUL1 and F-box protein, and it regulates ubiquitin-dependent proteolysis. CAND1 binds to CUL1, preventing it from associating with the other components that form the ligase. Neddylation of CUL1 (or the presence of SKP1 and ATP) dissociates it from CAND1, allowing the ligase complex to form [, , ]. CAND1 also interacts with CUL3, a component of the Cul3-dependent E3 ubiquitin ligase complex []. CAND1 has been proposed to be an F-box protein exchange factor, and as substrates of the ligase complex are degraded by the proteasome and depleted, the ligase complex enters an intermediate, deneddylated state when CAND1 can bind, promoting dissociation of the substrate-recognition subunit and recruitment of a new substrate-recognition subunit []. CAND2 is uncharacterized but is assumed to have similar roles to CAND1.
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