|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 311 for Dap

0.036s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_02
Specimen Label: euxassay_008199_02
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_03
Specimen Label: euxassay_008199_03
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_04
Specimen Label: euxassay_008199_04
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_05
Specimen Label: euxassay_008199_05
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_06
Specimen Label: euxassay_008199_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_07
Specimen Label: euxassay_008199_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_08
Specimen Label: euxassay_008199_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_09
Specimen Label: euxassay_008199_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_10
Specimen Label: euxassay_008199_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_20
Specimen Label: euxassay_008199_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_21
Specimen Label: euxassay_008199_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_22
Specimen Label: euxassay_008199_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_23
Specimen Label: euxassay_008199_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_24
Specimen Label: euxassay_008199_24
Detected: true
Specimen Num: 24
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_06
Specimen Label: euxassay_008199_06
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_07
Specimen Label: euxassay_008199_07
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_08
Specimen Label: euxassay_008199_08
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_09
Specimen Label: euxassay_008199_09
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_10
Specimen Label: euxassay_008199_10
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_11
Specimen Label: euxassay_008199_11
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_12
Specimen Label: euxassay_008199_12
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_19
Specimen Label: euxassay_008199_19
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_20
Specimen Label: euxassay_008199_20
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_21
Specimen Label: euxassay_008199_21
Detected: true
Specimen Num: 21
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_22
Specimen Label: euxassay_008199_22
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_23
Specimen Label: euxassay_008199_23
Detected: true
Specimen Num: 23
GXD Expression  
Probe: MGI:1059113
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1763923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824231
Age: embryonic day 14.5
Image: euxassay_008199_24
Specimen Label: euxassay_008199_24
Detected: true
Specimen Num: 24
Publication
First Author: Hao L
Year: 2009
Journal: Biol Reprod
Title: The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome.
Volume: 80
Issue: 5
Pages: 944-53
Publication
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
Publication      
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
Publication
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication      
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Inbal B
Year: 1997
Journal: Nature
Title: DAP kinase links the control of apoptosis to metastasis.
Volume: 390
Issue: 6656
Pages: 180-4
Publication
First Author: Friedrich ML
Year: 2005
Journal: Int Immunol
Title: DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection.
Volume: 17
Issue: 11
Pages: 1379-90
Publication
First Author: Guenebeaud C
Year: 2010
Journal: Mol Cell
Title: The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Volume: 40
Issue: 6
Pages: 863-76
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
Publication
First Author: Yang H
Year: 2015
Journal: Apoptosis
Title: Activation of NOD1 by DAP contributes to myocardial ischemia/reperfusion injury via multiple signaling pathways.
Volume: 20
Issue: 4
Pages: 512-22
Publication
First Author: Kamal M
Year: 2010
Journal: FEBS Lett
Title: C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.
Volume: 584
Issue: 3
Pages: 500-6
Interaction Experiment
Description: The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1442  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1430  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
GO Term
Publication
First Author: Kögel D
Year: 2001
Journal: Bioessays
Title: The DAP kinase family of pro-apoptotic proteins: novel players in the apoptotic game.
Volume: 23
Issue: 4
Pages: 352-8
Protein
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
Publication
First Author: Tanos BE
Year: 2013
Journal: Genes Dev
Title: Centriole distal appendages promote membrane docking, leading to cilia initiation.
Volume: 27
Issue: 2
Pages: 163-8
Protein Domain
Type: Family
Description: PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is an aconitate- isomerise converting trans-aconitate to cis-aconitate [, ].
Protein
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
Publication
First Author: Joo K
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: CCDC41 is required for ciliary vesicle docking to the mother centriole.
Volume: 110
Issue: 15
Pages: 5987-92
Protein Domain
Type: Family
Description: Centriole distal appendages (DAPs) anchor cilia to the plasma membrane and are thought to initiate primary cilium assembly through ciliary vesicles docking to the mother centriole. Centrosomal protein of 83kDa (Cep83), previously known as coiled-coil domain-containing protein 41 or CCDC41, is a DAP component required for the docking of ciliary vesicles []. Cep38 has been shown to recruit SCLT1 and Cep89, also DAP components, to centrioles [].
Publication
First Author: Garvey GS
Year: 2007
Journal: Protein Sci
Title: The three-dimensional crystal structure of the PrpF protein of Shewanella oneidensis complexed with trans-aconitate: insights into its biological function.
Volume: 16
Issue: 7
Pages: 1274-84
Publication
First Author: Das NK
Year: 2020
Journal: Cell Metab
Title: Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.
Volume: 31
Issue: 1
Pages: 115-130.e6
Publication
First Author: Fritz JD
Year: 1995
Journal: Pediatr Res
Title: Expression of deletion-containing dystrophins in mdx muscle: implications for gene therapy and dystrophin function.
Volume: 37
Issue: 6
Pages: 693-700
Protein Domain
Type: Domain
Description: Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped []into class I and class II. This entry includes proteins from both subfamilies, including class I LL-diaminopimelate aminotransferase, chloroplastic from Arabidopsis thaliana (Dap) and class II Histidinol-phosphate aminotransferase from Listeria welshimeri (HisC). Dap consists of two domains, a large domain and a small domain. This entry represents the large domain, which has a 3-layer α/β/α sandwich topology [].
Publication
First Author: Cheggour A
Year: 2000
Journal: Mol Microbiol
Title: The dppA gene of Bacillus subtilis encodes a new D-aminopeptidase.
Volume: 38
Issue: 3
Pages: 504-13
Publication
First Author: Mathiopoulos C
Year: 1991
Journal: Mol Microbiol
Title: A Bacillus subtilis dipeptide transport system expressed early during sporulation.
Volume: 5
Issue: 8
Pages: 1903-13
Protein Domain
Type: Family
Description: This entry contains the D-aminopeptidase dipeptide-binding protein (dppA; DAP dppA; MEROPS identifier M55.001). Peptide transport systems are found in many bacterial species and generally function to accumulate intact peptides in the cell, where they are hydrolyzed []. The dipeptide-binding protein (dppA) of Bacillus subtilis belongs to the dipeptide ABC transport (dpp) operon expressed early during sporulation. It is a binuclear zinc-dependent, D-specific aminopeptidase. The biologically active enzyme is a homodecamer with active sites buried in its channel. These self-compartmentalizing proteases are characterized by a SXDXEG motif []. D-Ala-D-Ala and D-Ala-Gly-Gly are the preferred substrates []. Bacillus subtilis dppA is thought to function as an adaptation to nutrient deficiency; hydrolysis of its substrate releases D-Ala which can be used subsequently as metabolic fuel [].
Protein Domain
Type: Homologous_superfamily
Description: Beta-Lactam antibiotics interfere with the biosynthesis of peptidoglycans in the bacterial cell wall by inactivating the penicillin-binding proteins DD-transpeptidases. Bacterial resistance to beta-lactam occurs through the synthesis of beta-lactmases that hydrolyse beta-lactam rings. D-aminopeptidase (DAP; peptidase family S12) is inhibited by beta-lactam antibiotics, and shares a low sequence identity with class C beta-lactamases and R61 DD-carboxypeptidase. DAP consists of three domains: the N-terminal domain A contains catalytic residues and displays a beta-lactamase-like fold (), domains B (middle) and C (C-terminal) domains are structurally similar, displaying an eight-stranded beta barrel []. Domain C is responsible for substrate and inhibitor specificity.This superfamily represents a structurally similar domain to domains B and C of D-aminopeptidase. Proteins in this entry include D-aminopeptidases and some uncharacterised hypothetical lipoproteins from Streptococcus.
Publication
First Author: Moukhles H
Year: 2001
Journal: J Neurochem
Title: Dystroglycan contributes to the formation of multiple dystrophin-like complexes in brain.
Volume: 78
Issue: 4
Pages: 824-34
Publication
First Author: Kawai T
Year: 1998
Journal: Mol Cell Biol
Title: ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Volume: 18
Issue: 3
Pages: 1642-51
Publication
First Author: Kawai T
Year: 2003
Journal: Mol Cell Biol
Title: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
Volume: 23
Issue: 17
Pages: 6174-86
Publication
First Author: Kawai T
Year: 1999
Journal: Oncogene
Title: Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Volume: 18
Issue: 23
Pages: 3471-80
Publication
First Author: Guo Q
Year: 2004
Journal: J Biol Chem
Title: AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.
Volume: 279
Issue: 6
Pages: 4596-603
Publication
First Author: Imamura M
Year: 2005
Journal: Hum Mol Genet
Title: Epsilon-sarcoglycan compensates for lack of alpha-sarcoglycan in a mouse model of limb-girdle muscular dystrophy.
Volume: 14
Issue: 6
Pages: 775-83