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Search results 101 to 138 out of 138 for Dock4

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Type Details Score
Protein Domain
IPR037808 | C2_Dock-C
Type: Domain
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents the C2 domain found in the Dock-C members. In addition to the C2 domain (also known as DHR-1 domain) and the DHR-2 domain, Dock-C members contain a functionally uncharacterised domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock1 (also known as Dock180) and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3) [, , ].
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Protein Domain
IPR037809 | C2_Dock-D
Type: Domain
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) []. This entry represents the C2 domain of the Dock-D members. In addition to the C2 domain (also known as the DHR-1 domain) and the DHR-2, Dock-D members contain a functionally uncharacterised domain and a PH domain upstream of the C2 domain. DHR-2 has the catalytic activity for Rac and/or Cdc42, but is structurally unrelated to the DH domain. The C2/DHR-1 domains of Dock1 (also known as Dock180) and Dock4 have been shown to bind phosphatidylinositol-3, 4, 5-triphosphate (PtdIns(3,4,5)P3). The PH domain broadly binds to phospholipids and is thought to be involved in targeting the plasma membrane [, , ].
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Publication
20167601 | -
First Author: Premkumar L
Year: 2010
Journal: J Biol Chem
Title: Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs).
Volume: 285
Issue: 17
Pages: 13211-22
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Protein
A0A0U1RNY4
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: true
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Protein
A0A1L1STJ1
Organism: Mus musculus/domesticus
Length: 477  
Fragment?: true
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Protein
Q3UHH9
Organism: Mus musculus/domesticus
Length: 1601  
Fragment?: true
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Protein
Q8VDR9
Organism: Mus musculus/domesticus
Length: 2080  
Fragment?: false
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Protein
Q8R1A4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
A0A1L1SQR4
Organism: Mus musculus/domesticus
Length: 2111  
Fragment?: false
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Protein
Q6ZPS1
Organism: Mus musculus/domesticus
Length: 1909  
Fragment?: true
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Protein
A0A0R4J2B7
Organism: Mus musculus/domesticus
Length: 1816  
Fragment?: true
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Protein
A0A0U1RNK7
Organism: Mus musculus/domesticus
Length: 2098  
Fragment?: false
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Protein
A2A9M5
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
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Protein
E9PX48
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
A2A9M4
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
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Protein
Q8CIQ7
Organism: Mus musculus/domesticus
Length: 2027  
Fragment?: false
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Protein
F8VPQ1
Organism: Mus musculus/domesticus
Length: 2030  
Fragment?: false
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Protein
Q8BZN6
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
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Protein
A2AF47
Organism: Mus musculus/domesticus
Length: 2073  
Fragment?: false
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Protein
Q8C147
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
Q8BIK4
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
F8VPN7
Organism: Mus musculus/domesticus
Length: 2113  
Fragment?: false
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Protein
A0A2X0U4P8
Organism: Mus musculus/domesticus
Length: 1942  
Fragment?: true
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Protein
B2RY79
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
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Protein
A0A2X0U2I4
Organism: Mus musculus/domesticus
Length: 2008  
Fragment?: false
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Protein
B9EJ70
Organism: Mus musculus/domesticus
Length: 2100  
Fragment?: false
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Protein
Q7TN11
Organism: Mus musculus/domesticus
Length: 1920  
Fragment?: true
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Protein
A0A1D5RMM1
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
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Protein
A0A1D5RLE0
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
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Protein
E9QMR2
Organism: Mus musculus/domesticus
Length: 2058  
Fragment?: false
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Protein
A2AF67
Organism: Mus musculus/domesticus
Length: 1902  
Fragment?: false
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Protein
A0A5F8MPL9
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
B2RXS7
Organism: Mus musculus/domesticus
Length: 2088  
Fragment?: false
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Protein
A0A087WQ86
Organism: Mus musculus/domesticus
Length: 2175  
Fragment?: false
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Protein
E9QM99
Organism: Mus musculus/domesticus
Length: 2187  
Fragment?: false
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Protein
A0A087WRP5
Organism: Mus musculus/domesticus
Length: 2151  
Fragment?: false
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Protein
B2RY08
Organism: Mus musculus/domesticus
Length: 2042  
Fragment?: false
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Protein
B2RWY0
Organism: Mus musculus/domesticus
Length: 2150  
Fragment?: false
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