Type |
Details |
Score |
Publication |
First Author: |
McFie PJ |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Endoplasmic reticulum-mitochondrial interaction mediated by mitofusin-1 or mitofusin-2 is not required for lipid droplet formation or adipocyte differentiation. |
Volume: |
478 |
Issue: |
1 |
Pages: |
392-397 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Lactate metabolism is essential in early-onset mitochondrial myopathy. |
Volume: |
9 |
Issue: |
1 |
Pages: |
eadd3216 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papanicolaou KN |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1309-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida Y |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. |
Volume: |
12 |
Issue: |
1 |
Pages: |
14883 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khacho M |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival. |
Volume: |
5 |
|
Pages: |
3550 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugiura A |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
MITOL regulates endoplasmic reticulum-mitochondria contacts via Mitofusin2. |
Volume: |
51 |
Issue: |
1 |
Pages: |
20-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yasukawa K |
Year: |
2009 |
Journal: |
Sci Signal |
Title: |
Mitofusin 2 inhibits mitochondrial antiviral signaling. |
Volume: |
2 |
Issue: |
84 |
Pages: |
ra47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2016 |
Journal: |
Mol Cell |
Title: |
Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis. |
Volume: |
61 |
Issue: |
1 |
Pages: |
111-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kwek XY |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Role of cardiac mitofusins in cardiac conduction following simulated ischemia-reperfusion. |
Volume: |
12 |
Issue: |
1 |
Pages: |
21049 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song M |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. |
Volume: |
26 |
Issue: |
6 |
Pages: |
872-883.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brooks C |
Year: |
2011 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. |
Volume: |
300 |
Issue: |
3 |
Pages: |
C447-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horn A |
Year: |
2020 |
Journal: |
J Cell Biol |
Title: |
Mitochondrial fragmentation enables localized signaling required for cell repair. |
Volume: |
219 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Liesa M |
Year: |
2008 |
Journal: |
PLoS One |
Title: |
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. |
Volume: |
3 |
Issue: |
10 |
Pages: |
e3613 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wani GA |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. |
Volume: |
38 |
Issue: |
7 |
Pages: |
110370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gӧbel J |
Year: |
2020 |
Journal: |
Cell Metab |
Title: |
Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. |
Volume: |
31 |
Issue: |
4 |
Pages: |
791-808.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Franco A |
Year: |
2020 |
Journal: |
Elife |
Title: |
Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Uo T |
Year: |
2009 |
Journal: |
Exp Neurol |
Title: |
Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons. |
Volume: |
218 |
Issue: |
2 |
Pages: |
274-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garedew A |
Year: |
2012 |
Journal: |
Cell Metab |
Title: |
Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1. |
Volume: |
15 |
Issue: |
4 |
Pages: |
466-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2013 |
Journal: |
Science |
Title: |
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. |
Volume: |
340 |
Issue: |
6131 |
Pages: |
471-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tondera D |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
SLP-2 is required for stress-induced mitochondrial hyperfusion. |
Volume: |
28 |
Issue: |
11 |
Pages: |
1589-600 |
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•
•
•
•
•
|
Publication |
First Author: |
Herkenne S |
Year: |
2020 |
Journal: |
Cell Metab |
Title: |
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1. |
Volume: |
31 |
Issue: |
5 |
Pages: |
987-1003.e8 |
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•
•
•
•
•
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Publication |
First Author: |
Song M |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. |
Volume: |
21 |
Issue: |
2 |
Pages: |
273-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang X |
Year: |
2018 |
Journal: |
Hum Mol Genet |
Title: |
CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10. |
Volume: |
27 |
Issue: |
22 |
Pages: |
3881-3900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ichinohe T |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection. |
Volume: |
110 |
Issue: |
44 |
Pages: |
17963-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan KQ |
Year: |
2019 |
Journal: |
Cell |
Title: |
Stress-Induced Metabolic Disorder in Peripheral CD4(+) T Cells Leads to Anxiety-like Behavior. |
Volume: |
179 |
Issue: |
4 |
Pages: |
864-879.e19 |
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•
•
•
•
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Publication |
First Author: |
Kasahara A |
Year: |
2013 |
Journal: |
Science |
Title: |
Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. |
Volume: |
342 |
Issue: |
6159 |
Pages: |
734-7 |
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•
•
•
•
•
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Publication |
First Author: |
Wang X |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle. |
Volume: |
132 |
Issue: |
23 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Stafa K |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. |
Volume: |
23 |
Issue: |
8 |
Pages: |
2055-77 |
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•
•
•
•
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Publication |
First Author: |
Waxman AB |
Year: |
2009 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins. |
Volume: |
41 |
Issue: |
4 |
Pages: |
385-96 |
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•
•
•
•
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Publication |
First Author: |
Ding Y |
Year: |
2023 |
Journal: |
Development |
Title: |
Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility. |
Volume: |
150 |
Issue: |
23 |
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•
•
•
•
•
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Publication |
First Author: |
Ishihara N |
Year: |
2009 |
Journal: |
Nat Cell Biol |
Title: |
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. |
Volume: |
11 |
Issue: |
8 |
Pages: |
958-66 |
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•
•
•
•
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Publication |
First Author: |
Moriya M |
Year: |
2015 |
Journal: |
Hum Mol Genet |
Title: |
Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. |
Volume: |
24 |
Issue: |
25 |
Pages: |
7349-60 |
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•
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•
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Publication |
First Author: |
Marta C |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. |
Volume: |
12 |
Issue: |
1 |
Pages: |
16152 |
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•
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Publication |
First Author: |
Suh J |
Year: |
2023 |
Journal: |
Cell Metab |
Title: |
Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. |
Volume: |
35 |
Issue: |
2 |
Pages: |
345-360.e7 |
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•
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Publication |
First Author: |
Hall EA |
Year: |
2017 |
Journal: |
Am J Hum Genet |
Title: |
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. |
Volume: |
100 |
Issue: |
5 |
Pages: |
706-724 |
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•
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Publication |
First Author: |
Meng TG |
Year: |
2023 |
Journal: |
Adv Sci (Weinh) |
Title: |
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition. |
Volume: |
10 |
Issue: |
27 |
Pages: |
e2301940 |
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Publication |
First Author: |
Ishihara T |
Year: |
2015 |
Journal: |
Mol Cell Biol |
Title: |
Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. |
Volume: |
35 |
Issue: |
1 |
Pages: |
211-23 |
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Publication |
First Author: |
Papanicolaou KN |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. |
Volume: |
111 |
Issue: |
8 |
Pages: |
1012-26 |
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Publication |
First Author: |
Li C |
Year: |
2024 |
Journal: |
Adv Sci (Weinh) |
Title: |
Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. |
Volume: |
11 |
Issue: |
11 |
Pages: |
e2305992 |
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Publication |
First Author: |
Gómez-Del Arco P |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. |
Volume: |
23 |
Issue: |
5 |
Pages: |
881-92 |
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Publication |
First Author: |
Menendez-Montes I |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. |
Volume: |
39 |
Issue: |
6 |
Pages: |
724-739 |
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Publication |
First Author: |
Kiyama T |
Year: |
2018 |
Journal: |
Mol Neurodegener |
Title: |
Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. |
Volume: |
13 |
Issue: |
1 |
Pages: |
56 |
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Publication |
First Author: |
Salazar-Petres E |
Year: |
2022 |
Journal: |
Biol Reprod |
Title: |
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. |
Volume: |
106 |
Issue: |
6 |
Pages: |
1292-1311 |
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Publication |
First Author: |
Wu Y |
Year: |
2016 |
Journal: |
PLoS Genet |
Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
Volume: |
12 |
Issue: |
9 |
Pages: |
e1006355 |
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Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Publication |
First Author: |
Pagliarini DJ |
Year: |
2008 |
Journal: |
Cell |
Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
Volume: |
134 |
Issue: |
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Pages: |
112-23 |
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First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
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Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
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First Author: |
Ko MS |
Year: |
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Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
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First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
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Cyagen Biosciences Inc. |
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First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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First Author: |
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Year: |
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Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
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First Author: |
The Gene Ontology Consortium |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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Magdaleno S |
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PLoS Biol |
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
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Mouse Genome Informatics Scientific Curators |
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Title: |
MGI Sequence Curation Reference |
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First Author: |
Mouse Genome Informatics Scientific Curators |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Scientific Curators |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
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Annotation inferences using phylogenetic trees |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics Scientific Curators |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Shahin S |
Year: |
2023 |
Journal: |
iScience |
Title: |
MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model. |
Volume: |
26 |
Issue: |
3 |
Pages: |
106270 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
741
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Fragment?: |
false |
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HT Experiment |
Series Id: |
GSE74888 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Allele |
Name: |
mitofusin 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Interaction Experiment |
Description: |
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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Allele |
Name: |
mitofusin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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Allele |
Name: |
transgene insertion HP51, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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•
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Strain |
Attribute String: |
mutant stock, transgenic |
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Publication |
First Author: |
Santel A |
Year: |
2003 |
Journal: |
J Cell Sci |
Title: |
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. |
Volume: |
116 |
Issue: |
Pt 13 |
Pages: |
2763-74 |
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Publication |
First Author: |
Legros F |
Year: |
2002 |
Journal: |
Mol Biol Cell |
Title: |
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. |
Volume: |
13 |
Issue: |
12 |
Pages: |
4343-54 |
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•
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Publication |
First Author: |
Head BP |
Year: |
2011 |
Journal: |
Mol Biol Cell |
Title: |
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. |
Volume: |
22 |
Issue: |
6 |
Pages: |
831-41 |
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Protein Domain |
Type: |
Family |
Description: |
Mitofusin-1 (MNF1) is an essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression of MNF1 induces the formation of mitochondrial networks [, , , ]. This entry includes the protein Marf from Drosophila (also known as Mitofusin) and the closely related protein fzo-1 from C. elegans, which is a transmembrane GTPase reported to be encoded by a mitochondrial fusion gene []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
319
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Fragment?: |
true |
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•
•
•
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Publication |
First Author: |
Huang G |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion. |
Volume: |
20 |
Issue: |
4 |
Pages: |
923-934 |
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•
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Publication |
First Author: |
Yu CY |
Year: |
2015 |
Journal: |
PLoS Pathog |
Title: |
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e1005350 |
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•
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•
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Publication |
First Author: |
Filadi R |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2. |
Volume: |
15 |
Issue: |
10 |
Pages: |
2226-2238 |
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•
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Publication |
First Author: |
Mandemakers W |
Year: |
2007 |
Journal: |
J Cell Sci |
Title: |
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. |
Volume: |
120 |
Issue: |
Pt 10 |
Pages: |
1707-16 |
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