Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the endocrine system. |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842622 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733122 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the immune system. |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1853522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3272922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skeleton (limbs, shoulder, hip). |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the face/soft tissues. |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1674822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876922 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5310402 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5423726 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in whisker follicle. |
Specimen Label: |
EN766; Specimen N369 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strausberg R |
Year: |
2002 |
Journal: |
GenBank Submission |
Title: |
Mus musculus, RIKEN cDNA 1190017B19 gene, clone MGC: 28240 IMAGE: 3992930, mRNA, complete cds |
|
|
Pages: |
BC020153 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pace HC |
Year: |
2000 |
Journal: |
Curr Biol |
Title: |
Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. |
Volume: |
10 |
Issue: |
15 |
Pages: |
907-17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mootha VK |
Year: |
2003 |
Journal: |
Cell |
Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
Volume: |
115 |
Issue: |
5 |
Pages: |
629-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
NIH Mouse Knockout Inventory |
Year: |
2004 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the NIH Mouse Knockout Inventory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Backcross DNA Panel Mapping Resource |
Year: |
1999 |
Journal: |
Database Release |
Title: |
JAX BSS Panel Mapping Data |
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|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
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•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
•
•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
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Title: |
Nomenclature Committee Use |
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•
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
276
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
196
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
69
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
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Fragment?: |
true |
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Publication |
First Author: |
Krasnikov BF |
Year: |
2009 |
Journal: |
Biochimie |
Title: |
Identification of the putative tumor suppressor Nit2 as omega-amidase, an enzyme metabolically linked to glutamine and asparagine transamination. |
Volume: |
91 |
Issue: |
9 |
Pages: |
1072-80 |
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Publication |
First Author: |
Peracchi A |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. |
Volume: |
114 |
Issue: |
16 |
Pages: |
E3233-E3242 |
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Publication |
First Author: |
Lin CH |
Year: |
2007 |
Journal: |
FEBS J |
Title: |
Growth inhibitory effect of the human NIT2 gene and its allelic imbalance in cancers. |
Volume: |
274 |
Issue: |
11 |
Pages: |
2946-56 |
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Publication |
First Author: |
Jaisson S |
Year: |
2009 |
Journal: |
Biochimie |
Title: |
Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2. |
Volume: |
91 |
Issue: |
9 |
Pages: |
1066-71 |
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Publication |
First Author: |
Semba S |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor. |
Volume: |
281 |
Issue: |
38 |
Pages: |
28244-53 |
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Publication |
First Author: |
Zhang H |
Year: |
2009 |
Journal: |
Int Immunol |
Title: |
Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. |
Volume: |
21 |
Issue: |
6 |
Pages: |
691-703 |
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Publication |
First Author: |
Sun J |
Year: |
2009 |
Journal: |
J Cell Biochem |
Title: |
Nit1 and Fhit tumor suppressor activities are additive. |
Volume: |
107 |
Issue: |
6 |
Pages: |
1097-106 |
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Publication |
First Author: |
Chien CH |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Structural insights into the catalytic active site and activity of human Nit2/ω-amidase: kinetic assay and molecular dynamics simulation. |
Volume: |
287 |
Issue: |
31 |
Pages: |
25715-26 |
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Protein Domain |
Type: |
Domain |
Description: |
Proteins containing this domain include mammalian Nit1 and Nit2, the Nit1-like domain of the invertebrate NitFhit, yeast Nit3 and various uncharacterized bacterial and archaeal Nit-like proteins. In general, they are amidases involved in various metabolic processes. Nit1 is a deaminated glutathione amidase [], while Nit2 is an omega-amidase []. They are candidate tumour suppressor proteins []. In NitFhit, the Nit1-like domain is encoded as a fusion protein with the non-homologous tumour suppressor, fragile histidine triad (Fhit) []. Mammalian Nit1 and Fhit may affect distinct signal pathways, and both may participate in DNA damage-induced apoptosis []. Nit1 is a negative regulator in T cells []. Overexpression of Nit2 in HeLa cells leads to a suppression of cell growth through cell cycle arrest in G2 []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
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Fragment?: |
false |
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Publication |
First Author: |
Rardin MJ |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. |
Volume: |
110 |
Issue: |
16 |
Pages: |
6601-6 |
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Publication |
First Author: |
Park J |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. |
Volume: |
50 |
Issue: |
6 |
Pages: |
919-30 |
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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