|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 230 for Skp2

0.037s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
GXD Expression    
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Male
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647028
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal day 6
Specimen Label: CNS
Detected: false
Specimen Num: 10
GXD Expression  
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3585958
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:3585958
Age: embryonic day 18.0
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 4
GXD Expression
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585958
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 5
GXD Expression
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585958
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal day 6-7
Specimen Label: P6/7
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585958
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 8
GXD Expression
Probe: MGI:3585060
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859224
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:3585958
Age: embryonic day 16.0
Image: E16
Note: Expression was detected in the vitreal outer neuroblastic layer.
Specimen Label: E16
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4947536
Assay Type: RNA in situ
Annotation Date: 2011-04-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360354
Pattern: Not Specified
Stage: TS04
Assay Id: MGI:4947545
Age: embryonic day 3.5
Note: There is general expression in all cells.
Specimen Label: 3A blastocyst
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4947536
Assay Type: RNA in situ
Annotation Date: 2011-04-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Not Specified
Stage: TS03
Assay Id: MGI:4947545
Age: embryonic day 3.0
Note: There is general expression in all cells.
Specimen Label: 3A morula
Detected: true
Specimen Num: 1
Publication
First Author: Kotake Y
Year: 2005
Journal: J Biol Chem
Title: Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation.
Volume: 280
Issue: 2
Pages: 1095-102
Publication
First Author: Zhong L
Year: 2007
Journal: J Clin Invest
Title: Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells.
Volume: 117
Issue: 10
Pages: 2869-76
Publication
First Author: Umanskaya K
Year: 2007
Journal: Mol Cell Biol
Title: Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor.
Volume: 27
Issue: 21
Pages: 7615-22
Publication
First Author: Maddika S
Year: 2009
Journal: Mol Cell Biol
Title: Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Volume: 29
Issue: 5
Pages: 1235-48
Publication
First Author: Shin HJ
Year: 2016
Journal: Nature
Title: AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy.
Volume: 534
Issue: 7608
Pages: 553-7
Publication
First Author: Zhao B
Year: 2019
Journal: Nat Immunol
Title: Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12.
Volume: 20
Issue: 10
Pages: 1381-1392
Publication
First Author: Piva R
Year: 2002
Journal: Mol Cell Biol
Title: In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Volume: 22
Issue: 23
Pages: 8375-87
Publication
First Author: Hatakeyama S
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
Volume: 96
Issue: 7
Pages: 3859-63
Publication
First Author: Maruyama S
Year: 2001
Journal: Genomics
Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.
Volume: 78
Issue: 3
Pages: 214-22
Publication
First Author: Lu Z
Year: 2013
Journal: EMBO J
Title: pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location.
Volume: 32
Issue: 6
Pages: 844-57
Publication
First Author: Wesselkamper SC
Year: 2006
Journal: Am J Respir Cell Mol Biol
Title: The role of metallothionein in the pathogenesis of acute lung injury.
Volume: 34
Issue: 1
Pages: 73-82
Publication
First Author: Li M
Year: 2008
Journal: Nat Cell Biol
Title: The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory.
Volume: 10
Issue: 9
Pages: 1083-9
Publication
First Author: Zhang Q
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.
Volume: 110
Issue: 3
Pages: 978-83
Publication
First Author: Huang Z
Year: 2004
Journal: Mol Cell Biol
Title: Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.
Volume: 24
Issue: 20
Pages: 8951-62
Publication
First Author: Chander H
Year: 2011
Journal: PLoS One
Title: Skp2B overexpression alters a prohibitin-p53 axis and the transcription of PAPP-A, the protease of insulin-like growth factor binding protein 4.
Volume: 6
Issue: 8
Pages: e22456
Publication  
First Author: Cinelli P
Year: 2008
Journal: BMC Dev Biol
Title: Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.
Volume: 8
Pages: 57
Publication
First Author: Golson ML
Year: 2015
Journal: Diabetes
Title: Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion.
Volume: 64
Issue: 11
Pages: 3829-38
Publication
First Author: Saiga T
Year: 2009
Journal: Mol Cell Biol
Title: Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Volume: 29
Issue: 13
Pages: 3529-43
Publication
First Author: Miranda-Carboni GA
Year: 2008
Journal: Genes Dev
Title: A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Volume: 22
Issue: 22
Pages: 3121-34
Publication
First Author: Kosaka Y
Year: 2012
Journal: Mol Cell Biol
Title: 14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle.
Volume: 32
Issue: 24
Pages: 5089-102
Publication
First Author: Ramakrishna S
Year: 2007
Journal: Dev Dyn
Title: Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.
Volume: 236
Issue: 4
Pages: 1000-13
Publication
First Author: Simonson L
Year: 2020
Journal: Dev Biol
Title: Keratin 13 deficiency causes white sponge nevus in mice.
Volume: 468
Issue: 1-2
Pages: 146-153
Publication
First Author: Jin J
Year: 2004
Journal: Genes Dev
Title: Systematic analysis and nomenclature of mammalian F-box proteins.
Volume: 18
Issue: 21
Pages: 2573-80
Publication
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Inuzuka H
Year: 2012
Journal: Cell
Title: Acetylation-dependent regulation of Skp2 function.
Volume: 150
Issue: 1
Pages: 179-93
Publication
First Author: Shim EH
Year: 2003
Journal: Cancer Res
Title: Expression of the F-box protein SKP2 induces hyperplasia, dysplasia, and low-grade carcinoma in the mouse prostate.
Volume: 63
Issue: 7
Pages: 1583-8
Publication
First Author: Cai Z
Year: 2020
Journal: Semin Cancer Biol
Title: The Skp2 Pathway: A Critical Target for Cancer Therapy.
Volume: 67
Issue: Pt 2
Pages: 16-33
Publication
First Author: Xu XL
Year: 2017
Journal: Cancer Res
Title: SKP2 Activation by Thyroid Hormone Receptor β2 Bypasses Rb-Dependent Proliferation in Rb-Deficient Cells.
Volume: 77
Issue: 24
Pages: 6838-6850
Publication
First Author: Wang J
Year: 2021
Journal: Ann N Y Acad Sci
Title: The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma.
Volume: 1490
Issue: 1
Pages: 90-104
Publication
First Author: Song P
Year: 2011
Journal: Circ Res
Title: AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells.
Volume: 109
Issue: 11
Pages: 1230-9
Publication
First Author: Chen J
Year: 2021
Journal: Oncogene
Title: EAG1 enhances hepatocellular carcinoma proliferation by modulating SKP2 and metastasis through pseudopod formation.
Volume: 40
Issue: 1
Pages: 163-176
Publication
First Author: Sicari BM
Year: 2012
Journal: Endocrinology
Title: c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein.
Volume: 153
Issue: 2
Pages: 861-72
Interaction Experiment
Description: Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2.
Publication
First Author: Hu L
Year: 2009
Journal: Cancer Res
Title: Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222.
Volume: 69
Issue: 8
Pages: 3374-81
GO Term
Allele
Name: S-phase kinase-associated protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Publication      
First Author: Wang GZ
Year: 2020
Journal: bioRxiv
Title: Degradation of SARS-CoV-2 receptor ACE2 by tobacco carcinogen-induced Skp2 in lung epithelial cells Running title: ACE2 catabolism in lung epithelial cells.
Interaction Experiment
Description: Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.
Publication
First Author: Michel JJ
Year: 1998
Journal: Cell Growth Differ
Title: Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
Volume: 9
Issue: 6
Pages: 435-49
Protein
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
Allele
Name: transgene insertion 4, Michele Pagano
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: congenic, mutant strain, targeted mutation
Allele
Name: transgene insertion 31, Hui Zhang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 33, Hui Zhang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(SKP2)4Paga/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Allele
Name: transgene insertion 79, Hui Zhang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Ilyin GP
Year: 2000
Journal: Genomics
Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.
Volume: 67
Issue: 1
Pages: 40-7
Publication
First Author: Kang-Decker N
Year: 2004
Journal: Cancer Cell
Title: Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
Volume: 5
Issue: 2
Pages: 177-89