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Search results 101 to 156 out of 156 for Tnfrsf10b

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Publication

30858352 | J:276962

First Author:	Kon N
Year:	2019
Journal:	Cell Death Dis
Title:	Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo.
Volume:	10
Issue:	3
Pages:	237

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Publication

26383973 | J:239805

First Author:	Grigaravicius P
Year:	2016
Journal:	Cell Death Differ
Title:	Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Volume:	23
Issue:	3
Pages:	454-68

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Publication

11239407 | J:74923

First Author:	Locksley RM
Year:	2001
Journal:	Cell
Title:	The TNF and TNF receptor superfamilies: integrating mammalian biology.
Volume:	104
Issue:	4
Pages:	487-501

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Publication

18776938 | J:141141

First Author:	Song B
Year:	2008
Journal:	J Clin Invest
Title:	Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
Volume:	118
Issue:	10
Pages:	3378-89

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Publication

12819136 | J:84168

First Author:	Reed JC
Year:	2003
Journal:	Genome Res
Title:	Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume:	13
Issue:	6B
Pages:	1376-88

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Publication

- | J:342609

First Author:	UniProt
Year:	2021

Title:	Electronic Gene Ontology annotations created by ARBA machine learning models

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Publication

- | J:238766

First Author:	Shanghai Model Organisms Center
Year:	2017
Journal:	MGI Direct Data Submission
Title:	Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China

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Publication

- | J:82809

First Author:	European Mouse Mutant Archive
Year:	2003
Journal:	Unpublished
Title:	Information obtained from the European Mouse Mutant Archive (EMMA)

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Publication

- | J:66660

First Author:	Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year:	2001

Title:	LocusLink Collaboration

•

Publication

- | J:94790

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Mouse Synonym Curation

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Publication

- | J:80155

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data

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Publication

- | J:155845

First Author:	Wellcome Trust Sanger Institute
Year:	2010
Journal:	MGI Direct Data Submission
Title:	Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute

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Publication

- | J:326541

First Author:	Cyagen Biosciences Inc.
Year:	2022

Title:	Cyagen Biosciences Website.

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Publication

- | J:171409

First Author:	GUDMAP Consortium
Year:	2004
Journal:	www.gudmap.org
Title:	GUDMAP: the GenitoUrinary Development Molecular Anatomy Project

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Publication

- | J:155856

First Author:	The Gene Ontology Consortium
Year:	2014

Title:	Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

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Publication

16602821 | J:162220

First Author:	Magdaleno S
Year:	2006
Journal:	PLoS Biol
Title:	BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume:	4
Issue:	4
Pages:	e86

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Publication

16141072 | J:99680

First Author:	Carninci P
Year:	2005
Journal:	Science
Title:	The transcriptional landscape of the mammalian genome.
Volume:	309
Issue:	5740
Pages:	1559-63

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Publication

11217851 | J:65060

First Author:	Kawai J
Year:	2001
Journal:	Nature
Title:	Functional annotation of a full-length mouse cDNA collection.
Volume:	409
Issue:	6821
Pages:	685-90

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Publication

14610273 | J:86696

First Author:	Zambrowicz BP
Year:	2003
Journal:	Proc Natl Acad Sci U S A
Title:	Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume:	100
Issue:	24
Pages:	14109-14

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Publication

- | J:23000

First Author:	MGD Nomenclature Committee
Year:	1995

Title:	Nomenclature Committee Use

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Publication

- | J:141210

First Author:	Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year:	2008
Journal:	Database Download
Title:	Mouse Gene Trap Data Load from dbGSS

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Publication

21677750 | J:173534

First Author:	Skarnes WC
Year:	2011
Journal:	Nature
Title:	A conditional knockout resource for the genome-wide study of mouse gene function.
Volume:	474
Issue:	7351
Pages:	337-42

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Publication

- | J:293217

First Author:	GemPharmatech
Year:	2020

Title:	GemPharmatech Website.

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Publication

- | J:342587

First Author:	AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year:	2011

Title:	Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

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Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

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Publication

- | J:164563

First Author:	The Gene Ontology Consortium
Year:	2010

Title:	Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

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Publication

- | J:57747

First Author:	MGI Genome Annotation Group and UniGene Staff
Year:	2015
Journal:	Database Download
Title:	MGI-UniGene Interconnection Effort

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Publication

- | J:161428

First Author:	Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year:	2010

Title:	Annotation inferences using phylogenetic trees

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Publication

- | J:63103

First Author:	Mouse Genome Database and National Center for Biotechnology Information
Year:	2000
Journal:	Database Release
Title:	Entrez Gene Load

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

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Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

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Allele

Tnfrsf10b<em1(TNFRSF10B)Smoc> | MGI:7292870

Name:	tumor necrosis factor receptor superfamily, member 10b; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Humanized sequence, Inserted expressed sequence

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Allele

Tnfrsf10b<em2Smoc> | MGI:7292871

Name:	tumor necrosis factor receptor superfamily, member 10b; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

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Strain

MGI:6771225 | C57BL/6J-Tnfrsf10b<em1(TNFRSF10B)Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

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Strain

MGI:6429696 | C57BL/6J-Tnfrsf10B<em2Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, endonuclease-mediated mutation

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HT Experiment

E-GEOD-6323 | Transcription profiling of skeletal muscles from young, old, and old calorie restricted C57BL/6NHsd mice to investigate age-related changes in the transcriptional profile

Series Id:	GSE6323
Experiment Type:	transcription profiling by array
Study Type:	Baseline
Source:	ArrayExpress

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Publication

15538968 | -

First Author:	Kimberley FC
Year:	2004
Journal:	Cell Res
Title:	Following a TRAIL: update on a ligand and its five receptors.
Volume:	14
Issue:	5
Pages:	359-72

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Publication

23584885 | -

First Author:	Gottwald L
Year:	2013
Journal:	Arch Gynecol Obstet
Title:	Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study.
Volume:	288
Issue:	4
Pages:	889-99

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Publication

24649804 | -

First Author:	Gottwald L
Year:	2014
Journal:	J Obstet Gynaecol
Title:	Membrane expression of trail receptors DcR1 and DcR2 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.
Volume:	34
Issue:	4
Pages:	346-9

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Publication

24211571 | -

First Author:	Venza M
Year:	2013
Journal:	Biochem Biophys Res Commun
Title:	Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Volume:	441
Issue:	4
Pages:	743-50

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Publication

18310272 | -

First Author:	Murphy TM
Year:	2008
Journal:	Endocr Relat Cancer
Title:	The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer.
Volume:	15
Issue:	1
Pages:	11-25

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Publication

20571073 | -

First Author:	Spitzer D
Year:	2010
Journal:	Mol Cancer Ther
Title:	A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.
Volume:	9
Issue:	7
Pages:	2142-51

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Publication

12655296 | -

First Author:	LeBlanc HN
Year:	2003
Journal:	Cell Death Differ
Title:	Apo2L/TRAIL and its death and decoy receptors.
Volume:	10
Issue:	1
Pages:	66-75

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Publication

9430228 | -

First Author:	Schneider P
Year:	1997
Journal:	Immunity
Title:	TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Volume:	7
Issue:	6
Pages:	831-6

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Publication

16980609 | -

First Author:	Mérino D
Year:	2006
Journal:	Mol Cell Biol
Title:	Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Volume:	26
Issue:	19
Pages:	7046-55

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Protein Domain

IPR034024 | TNFRSF10_N

Type:

Domain

Description:

Tumor necrosis factor receptor superfamily member 10 (TNFRSF10) family contains TNFRSF10A (also known as DR4, Apo2, TRAIL-R1, CD261), TNFRSF10B (also known as DR5, KILLER, TRICK2A, TRAIL-R2, TRICKB, CD262), TNFRSF10C (also known as DcR1, TRAIL-R3, LIT, TRID, CD263), and TNFRSF10D (also known as DcR2, TRUNDD, TRAIL-R4, CD264). Tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL) binds to all 4 receptors.DR4 (TRAIL-R1) and DR5 (TRAIL-R2) are membrane-bound and contain a death domain in their intracellular portion, which is able to transmit an apoptotic signal, thus often called death receptors. In contrast, DcR1 (TRAIL-R3), which lacks the complete intracellular portion and DcR2 (TRAIL-R4), which has a truncated cytoplasmic death domain, do not transmit an apoptotic signal, thus known as decoy receptors [, ]. Apoptosis mediated by DR4 and DR5 requires Fas (TNFRSF6)-associated via death domain (FADD), a death domain containing adaptor protein []. DcR1 appears to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis; DcR2 has been shown to play an inhibitory role in TRAIL-induced cell apoptosis []. The membrane expression of all of these receptors (DR4, DR5, DcR1, and DcR2) is greater in normal endometrium (NE) than in endometrioid adenocarcinoma (EAC) [, ]. In EAC patients, membrane expression of these receptors are not independent predictors of survival. DcR1 and DcR2 expression is critical in cell growth and apoptosis in cutaneous or uveal melanoma []; DcR1 and DcR2 are frequently methylated in both, leading to loss of gene expression and melanomagenesis. On the other hand, DR4 and DR5 methylation is rare in cutaneous melanoma and frequent in uveal melanoma; their expression is wholly independent of the promoter methylation status. DcR1 and DcR2 genes are also reported to be hyper-methylated in prostate cancer []. The TRAIL ligand, a potent and specific inducer of apoptosis in cancer cells, has been explored as a therapeutic drug; experimental data has shown that DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic cancer [].This entry represents the N-terminal domain of TNFRSF10. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].

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Protein

Q9QZM4

Organism:	Mus musculus/domesticus
Length:	381
Fragment?:	false

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Publication

9538693 | -

First Author:	Naismith JH
Year:	1998
Journal:	Trends Biochem Sci
Title:	Modularity in the TNF-receptor family.
Volume:	23
Issue:	2
Pages:	74-9

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Publication

11796220 | -

First Author:	Bodmer JL
Year:	2002
Journal:	Trends Biochem Sci
Title:	The molecular architecture of the TNF superfamily.
Volume:	27
Issue:	1
Pages:	19-26

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Publication

8387891 | -

First Author:	Banner DW
Year:	1993
Journal:	Cell
Title:	Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.
Volume:	73
Issue:	3
Pages:	431-45

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