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Search results 101 to 170 out of 170 for Tollip

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Type Details Score
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Interaction Experiment
Hu Y (2009)
Description: Tollip attenuated the hypertrophic response of cardiomyocytes induced by IL-1beta.
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Allele
Tollip<em2Smoc> | MGI:7292924
Name: toll interacting protein; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
19273233 | -
 
First Author: Hu Y
Year: 2009
Journal: Front Biosci (Landmark Ed)
Title: Tollip attenuated the hypertrophic response of cardiomyocytes induced by IL-1beta.
Volume: 14
Pages: 2747-56
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Interaction Experiment
Oguro A (2011)
Description: Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins.
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Strain
MGI:6429718 | C57BL/6J-Tollip<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
21896309 | -
First Author: Oguro A
Year: 2011
Journal: Neurosci Lett
Title: Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins.
Volume: 503
Issue: 3
Pages: 234-9
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Allele
Tollip<em1Smoc> | MGI:7292923
Name: toll interacting protein; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Protein Domain
IPR041799 | TOLIP_CUE
Type: Domain
Description: Tollip (Toll-interacting protein) is a component of the IL-1RI pathway which contains an N-terminal C2 domain and a C-terminal CUE domain. Tollip binds to the cytoplasmic TIR domain of IL-1Rs after IL-1 stimulation. It is sufficient for recruitment of IRAK to IL-1Rs and negatively regulates IL-1-induced signaling by inhibiting IRAK phosphorylation. In addition, Tollip directly interacts with toll-like receptors TLR2 and TLR4, and plays an inhibitory role in TLR-mediated cell activation through suppressing phosphorylation and kinase activity of IRAK. Moreover, Tollip can associate with GAT domains of Tom1 and its related proteins Tom1L1 and Tom1L2, and facilitate the recruitment of clathrin onto endosomes [, ].
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Publication
11751856 | -
First Author: Zhang G
Year: 2002
Journal: J Biol Chem
Title: Negative regulation of toll-like receptor-mediated signaling by Tollip.
Volume: 277
Issue: 9
Pages: 7059-65
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Protein
P70295
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
F6XIV6
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: true
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Protein
Q3U3K9
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
A0A0N4SVA6
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
I6L970
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Protein
Q3TAZ9
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q3TBX5
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Publication
12573224 | -
First Author: Donaldson KM
Year: 2003
Journal: Curr Biol
Title: Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p.
Volume: 13
Issue: 3
Pages: 258-62
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Publication
23665229 | -
First Author: Bagola K
Year: 2013
Journal: Mol Cell
Title: Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases.
Volume: 50
Issue: 4
Pages: 528-39
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Protein Domain
IPR003892 | CUE
Type: Domain
Description: This domain promotes intramolecular monoubiquitination and has a dual role in mono- and poly-ubiquitination recognition, being involved in binding ubiquitin-conjugating enzymes (UBCs) [, , ]. CUE domains also occur in two proteins of the IL-1 signal transduction pathway, tollip and TAB2.
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Protein Domain
IPR037301 | Tollip_C2
Type: Domain
Description: Tollip is a part of the Interleukin-1 receptor (IL-1R) signaling pathway. Tollip is proposed to link serine/threonine kinase IRAK to IL-1Rs as well as inhibiting phosphorylation of IRAK []. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates []. There is a single C2 domain present in Tollip. C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements, type I and type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide varietyof substances including phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions [, , , , , , , ].
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Protein
Q9QZ06
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
F7AT44
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
A9JEI5
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Protein
Q8BQL7
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: false
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Protein
Q9CXX9
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Protein
A0A494BAT2
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: false
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Protein
A0A494BBK6
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: true
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Protein
A0A494BB93
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q9CVB0
Organism: Mus musculus/domesticus
Length: 246  
Fragment?: true
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Publication
25042851 | -
First Author: Lu K
Year: 2014
Journal: Cell
Title: Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family.
Volume: 158
Issue: 3
Pages: 549-63
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Publication
23404570 | J:195046
First Author: Sandig H
Year: 2013
Journal: Eur J Immunol
Title: IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
Volume: 43
Issue: 4
Pages: 979-88
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Publication
34432562 | J:347614
First Author: Xu Z
Year: 2022
Journal: Autophagy
Title: Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib.
Volume: 18
Issue: 5
Pages: 1152-1173
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Publication
27741296 | J:256804
First Author: Sugi Y
Year: 2016
Journal: PLoS One
Title: Post-Transcriptional Regulation of Toll-Interacting Protein in the Intestinal Epithelium.
Volume: 11
Issue: 10
Pages: e0164858
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Protein
Q8R3V6
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
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Protein
F2Z3X3
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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Protein
F7AT87
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
Q3TRP3
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Protein
D3Z216
Organism: Mus musculus/domesticus
Length: 553  
Fragment?: true
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Protein
B7ZNF1
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
A2RS63
Organism: Mus musculus/domesticus
Length: 388  
Fragment?: false
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Publication
12628920 | -
First Author: Shih SC
Year: 2003
Journal: EMBO J
Title: A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain.
Volume: 22
Issue: 6
Pages: 1273-81
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Publication
19912257 | J:170066
First Author: Oshima N
Year: 2010
Journal: Clin Exp Immunol
Title: A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation.
Volume: 159
Issue: 2
Pages: 185-98
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Protein
Q8C5G6
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false
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Protein
Q91WR3
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
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Protein
Q3UG63
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Publication
7791877 | J:26068
First Author: Li C
Year: 1995
Journal: Nature
Title: Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.
Volume: 375
Issue: 6532
Pages: 594-9
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Publication
2333096 | -
First Author: Perin MS
Year: 1990
Journal: Nature
Title: Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.
Volume: 345
Issue: 6272
Pages: 260-3
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Publication
1589771 | -
First Author: Brose N
Year: 1992
Journal: Science
Title: Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
Volume: 256
Issue: 5059
Pages: 1021-5
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Publication
8662510 | -
First Author: Shao X
Year: 1996
Journal: Science
Title: Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C.
Volume: 273
Issue: 5272
Pages: 248-51
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Protein
Q571K4
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
Q99K90
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
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Protein
Q9R049
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
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Protein
Q3TCI2
Organism: Mus musculus/domesticus
Length: 639  
Fragment?: false
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Protein
Q3U007
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: false
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Protein
B1ASY9
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Publication
7697723 | -
First Author: Sutton RB
Year: 1995
Journal: Cell
Title: Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.
Volume: 80
Issue: 6
Pages: 929-38
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Protein
Q04692
Organism: Mus musculus/domesticus
Length: 1021  
Fragment?: false
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Publication
8771209 | -
First Author: Ponting CP
Year: 1996
Journal: Protein Sci
Title: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin.
Volume: 5
Issue: 1
Pages: 162-6
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Publication
9632630 | -
First Author: Rizo J
Year: 1998
Journal: J Biol Chem
Title: C2-domains, structure and function of a universal Ca2+-binding domain.
Volume: 273
Issue: 26
Pages: 15879-82
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Publication
8976547 | -
First Author: Nalefski EA
Year: 1996
Journal: Protein Sci
Title: The C2 domain calcium-binding motif: structural and functional diversity.
Volume: 5
Issue: 12
Pages: 2375-90
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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