| Type |
Details |
Score |
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE38891 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE38895 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE26822 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE55376 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE55377 |
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hill DA |
| Year: |
2009 |
| Journal: |
Science |
| Title: |
DICER1 mutations in familial pleuropulmonary blastoma. |
| Volume: |
325 |
| Issue: |
5943 |
| Pages: |
965 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Foulkes WD |
| Year: |
2011 |
| Journal: |
Hum Mutat |
| Title: |
Extending the phenotypes associated with DICER1 mutations. |
| Volume: |
32 |
| Issue: |
12 |
| Pages: |
1381-4 |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 0 |
| Stage: |
27 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 0 |
| Stage: |
27 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 0 |
| Stage: |
27 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 5 |
| Stage: |
28 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 5 |
| Stage: |
28 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| HT Sample |
| Organism Name: |
mouse, laboratory |
| Sex: |
Male |
| Age: |
postnatal day 5 |
| Stage: |
28 |
| Structure . Name: |
testis |
| Notes: |
control animals were either Dicer1 flox/flox or were Dicer 1 flox/wt; Mis-Cre |
| Curation Status: |
Curated |
|
•
•
•
•
•
|
| Allele |
| Name: |
dicer 1, ribonuclease type III; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rio Frio T |
| Year: |
2011 |
| Journal: |
JAMA |
| Title: |
DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. |
| Volume: |
305 |
| Issue: |
1 |
| Pages: |
68-77 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Klein S |
| Year: |
2014 |
| Journal: |
J Med Genet |
| Title: |
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome. |
| Volume: |
51 |
| Issue: |
5 |
| Pages: |
294-302 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Allele |
| Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Masahiko Kuroda |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
| Allele |
| Name: |
dicer 1, ribonuclease type III; targeted mutation 1, Sarah E Millar |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Allele |
| Name: |
dicer 1, ribonuclease type III; mutation 1, Bruce Beutler |
| Allele Type: |
Chemically induced (ENU) |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (theIFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang X |
| Year: |
2002 |
| Journal: |
Biochem J |
| Title: |
The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR). |
| Volume: |
366 |
| Issue: |
Pt 1 |
| Pages: |
175-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Singh M |
| Year: |
2012 |
| Journal: |
J Cell Biochem |
| Title: |
Increased interaction between PACT molecules in response to stress signals is required for PKR activation. |
| Volume: |
113 |
| Issue: |
8 |
| Pages: |
2754-64 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the first DSRM of PRKRA. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the second DSRM of PRKRA. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the third DSRM of PRKRA. |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant strain, chemically induced mutation, coisogenic |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 |
| Background: |
C57BL/6J-Dicer1 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 |
| Background: |
involves: 129S7/SvEvBrd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 |
| Background: |
involves: 129S7/SvEvBrd * FVB/N |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1<+> |
| Background: |
involves: 129S7/SvEvBrd * FVB/N |
| Zygosity: |
ht |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6 |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Davalos V |
| Year: |
2012 |
| Journal: |
Cancer Cell |
| Title: |
Rolling the dice to discover the role of DICER in tumorigenesis. |
| Volume: |
21 |
| Issue: |
6 |
| Pages: |
717-9 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE69882 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE69881 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(KRT14-cre)52Smr/? |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6J * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Zp3-cre)93Knw/? |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
313
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee Y |
| Year: |
2006 |
| Journal: |
EMBO J |
| Title: |
The role of PACT in the RNA silencing pathway. |
| Volume: |
25 |
| Issue: |
3 |
| Pages: |
522-32 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Myh6-cre)2182Mds/? |
| Background: |
involves: 129S7/SvEvBrd * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/? |
| Background: |
involves: 129S7/SvEvBrd * FVB |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
| Background: |
involves: 129S2/SvPas * 129S7/SvEvBrd |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/? |
| Background: |
involves: 129S7/SvEvBrd * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/? |
| Background: |
involves: 129S7/SvEvBrd * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/? |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE22023 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(KRT5-rtTA)1Glk/? Tg(tetO-cre)1Jaw/? |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Pax8/Pax8<+> |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1<+> Emx1/Emx1<+> |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Stra8-icre)1Reb/? |
| Background: |
involves: 129S1/SvImJ * 129S7/SvEvBrd * FVB/NJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Emx1/Emx1<+> |
| Background: |
involves: 129P2/OlaHsd * 129S7/SvEvBrd |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2007 |
| Journal: |
Nat Genet |
| Title: |
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. |
| Volume: |
39 |
| Issue: |
3 |
| Pages: |
380-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gelfand BD |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. |
| Volume: |
11 |
| Issue: |
11 |
| Pages: |
1686-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao H |
| Year: |
2010 |
| Journal: |
J Dent Res |
| Title: |
MicroRNAs play a critical role in tooth development. |
| Volume: |
89 |
| Issue: |
8 |
| Pages: |
779-84 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yi R |
| Year: |
2008 |
| Journal: |
Nature |
| Title: |
A skin microRNA promotes differentiation by repressing 'stemness'. |
| Volume: |
452 |
| Issue: |
7184 |
| Pages: |
225-9 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE68537 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Dicer1/Dicer1 Tg(Ddx4-cre)1Dcas/? |
| Background: |
involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE46264 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2019 |
| Journal: |
Biol Reprod |
| Title: |
CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†. |
| Volume: |
101 |
| Issue: |
1 |
| Pages: |
50-62 |
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