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Details |
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| First Author: |
Engelkamp D |
| Year: |
2002 |
| Journal: |
Mech Dev |
| Title: |
Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. |
| Volume: |
118 |
| Issue: |
1-2 |
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191-7 |
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| First Author: |
Braisted JE |
| Year: |
2000 |
| Journal: |
J Neurosci |
| Title: |
Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection. |
| Volume: |
20 |
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15 |
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| First Author: |
Xu K |
| Year: |
2014 |
| Journal: |
Science |
| Title: |
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. |
| Volume: |
344 |
| Issue: |
6189 |
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1275-9 |
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Bloch-Gallego E |
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1999 |
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J Neurosci |
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Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. |
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19 |
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11 |
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Andrusiak MG |
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2011 |
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Mol Cell Biol |
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Rb/E2F regulates expression of neogenin during neuronal migration. |
| Volume: |
31 |
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2 |
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| First Author: |
Jiang Y |
| Year: |
2003 |
| Journal: |
Dev Biol |
| Title: |
Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. |
| Volume: |
258 |
| Issue: |
2 |
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Hakanen J |
| Year: |
2015 |
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Int J Dev Neurosci |
| Title: |
Defects in neural guidepost structures and failure to remove leptomeningeal cells from the septal midline behind the interhemispheric fusion defects in Netrin1 deficient mice. |
| Volume: |
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| Issue: |
Pt B |
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206-15 |
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| First Author: |
Palmesino E |
| Year: |
2012 |
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J Neurosci |
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Genetic analysis of DSCAM's role as a Netrin-1 receptor in vertebrates. |
| Volume: |
32 |
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van Erp S |
| Year: |
2015 |
| Journal: |
Dev Cell |
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Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases. |
| Volume: |
35 |
| Issue: |
5 |
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537-52 |
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| First Author: |
Fitzgerald DP |
| Year: |
2006 |
| Journal: |
Neuroscience |
| Title: |
Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain. |
| Volume: |
142 |
| Issue: |
3 |
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703-16 |
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| First Author: |
Fitzgerald DP |
| Year: |
2007 |
| Journal: |
Gene Expr Patterns |
| Title: |
Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system. |
| Volume: |
7 |
| Issue: |
7 |
| Pages: |
784-92 |
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| First Author: |
Metzger M |
| Year: |
2005 |
| Journal: |
Dev Dyn |
| Title: |
Gene expression of the repulsive guidance molecules during development of the mouse intestine. |
| Volume: |
234 |
| Issue: |
1 |
| Pages: |
169-75 |
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| First Author: |
van den Heuvel DM |
| Year: |
2013 |
| Journal: |
PLoS One |
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Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain. |
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| First Author: |
Kang JS |
| Year: |
2004 |
| Journal: |
J Cell Biol |
| Title: |
Netrins and neogenin promote myotube formation. |
| Volume: |
167 |
| Issue: |
3 |
| Pages: |
493-504 |
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| First Author: |
Liu Y |
| Year: |
2004 |
| Journal: |
Curr Biol |
| Title: |
Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. |
| Volume: |
14 |
| Issue: |
10 |
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897-905 |
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| First Author: |
McClellan KA |
| Year: |
2007 |
| Journal: |
Mol Cell Biol |
| Title: |
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. |
| Volume: |
27 |
| Issue: |
13 |
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4825-43 |
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| First Author: |
Huang Z |
| Year: |
2016 |
| Journal: |
J Neurosci |
| Title: |
Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex. |
| Volume: |
36 |
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21 |
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5833-49 |
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| First Author: |
Matilainen T |
| Year: |
2007 |
| Journal: |
Int J Dev Biol |
| Title: |
Analysis of Netrin 1 receptors during inner ear development. |
| Volume: |
51 |
| Issue: |
5 |
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409-13 |
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| First Author: |
Bin JM |
| Year: |
2015 |
| Journal: |
Cell Rep |
| Title: |
Complete Loss of Netrin-1 Results in Embryonic Lethality and Severe Axon Guidance Defects without Increased Neural Cell Death. |
| Volume: |
12 |
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7 |
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Yung AR |
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2018 |
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Cell Rep |
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Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. |
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| First Author: |
Kam JW |
| Year: |
2016 |
| Journal: |
Development |
| Title: |
RGMB and neogenin control cell differentiation in the developing olfactory epithelium. |
| Volume: |
143 |
| Issue: |
9 |
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1534-46 |
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Leighton PA |
| Year: |
2001 |
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Nature |
| Title: |
Defining brain wiring patterns and mechanisms through gene trapping in mice. |
| Volume: |
410 |
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6825 |
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Lin S |
| Year: |
2020 |
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J Mol Cell Biol |
| Title: |
Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation. |
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12 |
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Garrett AM |
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2016 |
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Front Mol Neurosci |
| Title: |
Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. |
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Miyoshi G |
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Neuron |
| Title: |
Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate. |
| Volume: |
74 |
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6 |
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Yung AR |
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Development |
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Phenotypic analysis of mice completely lacking netrin 1. |
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Leggere JC |
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Elife |
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NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. |
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Steele-Perkins G |
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Mol Cell Biol |
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The transcription factor gene Nfib is essential for both lung maturation and brain development. |
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Genes Dev |
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Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. |
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Müller M |
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Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. |
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Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. |
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Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. |
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Cancer Res |
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Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Allele |
| Name: |
transgene insertion B17-2, Michael I Kotlikoff |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
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| Publication |
| First Author: |
Hagihara M |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
Neogenin, a receptor for bone morphogenetic proteins. |
| Volume: |
286 |
| Issue: |
7 |
| Pages: |
5157-65 |
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| Publication |
| First Author: |
Zhang Q |
| Year: |
2015 |
| Journal: |
Oncol Rep |
| Title: |
Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells. |
| Volume: |
34 |
| Issue: |
1 |
| Pages: |
258-64 |
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| Publication |
| First Author: |
Rajagopalan S |
| Year: |
2004 |
| Journal: |
Nat Cell Biol |
| Title: |
Neogenin mediates the action of repulsive guidance molecule. |
| Volume: |
6 |
| Issue: |
8 |
| Pages: |
756-62 |
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| Publication |
| First Author: |
Wilson NH |
| Year: |
2007 |
| Journal: |
Int J Biochem Cell Biol |
| Title: |
Neogenin: one receptor, many functions. |
| Volume: |
39 |
| Issue: |
5 |
| Pages: |
874-8 |
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| Publication |
| First Author: |
Wilson NH |
| Year: |
2006 |
| Journal: |
Dev Biol |
| Title: |
Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain. |
| Volume: |
296 |
| Issue: |
2 |
| Pages: |
485-98 |
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| Publication |
| First Author: |
Matsunaga E |
| Year: |
2004 |
| Journal: |
Dev Growth Differ |
| Title: |
Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development. |
| Volume: |
46 |
| Issue: |
6 |
| Pages: |
481-6 |
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| Publication |
| First Author: |
Kim SJ |
| Year: |
2014 |
| Journal: |
Oncotarget |
| Title: |
Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer. |
| Volume: |
5 |
| Issue: |
10 |
| Pages: |
3386-98 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Neogenin (NEO1) is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily []. It displays identical secondary structure to DCC (deleted in colorectal cancer), a netrin receptor that is involved in axon guidance and cell survival. Similar to DCC, it is able to transduce signals elicited by netrin []. Netrin-Neogenin interactions result in a chemoattractive axon guidance response []. Neogenin is also a receptor for members of the repulsive guidance molecule (RGM) family, which act as a repulsive axon guidance cue [, , ]. RGM binding to NEO1 activates the bone morphogenetic protein (BMP)-regulated signalling involved in morphogenesis and iron homeostasis [, ].Neogenin has an important role in cancer development [, ]. |
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| Allele |
| Name: |
transgene insertion B10-3, Michael I Kotlikoff |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
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| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
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| Strain |
| Attribute String: |
mutant stock, transgenic |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
231
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Tian C |
| Year: |
2013 |
| Journal: |
Mol Reprod Dev |
| Title: |
Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling. |
| Volume: |
80 |
| Issue: |
9 |
| Pages: |
700-17 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1493
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
405
 |
| Fragment?: |
true |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1492
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1465
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Lee FK |
| Year: |
2021 |
| Journal: |
Elife |
| Title: |
Genetically engineered mice for combinatorial cardiovascular optobiology. |
| Volume: |
10 |
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