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Search results 1001 to 1100 out of 1143 for Notch3

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Type Details Score
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: notch 3; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Genotype
Symbol: Tg(Pdx1-Notch3)1Heed/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3
Background: C57BL/6J-Notch3/GrsrJ
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3<+>
Background: involves: 129S/SvEv * Swiss
Zygosity: ht
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3
Background: involves: 129S/SvEv * Swiss
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Notch3/Notch3
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Notch1/Notch1<+> Notch3/Notch3
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
DO Term
DO Term
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1247  
Fragment?: false
HT Experiment
Series Id: GSE36437
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Spyros Artavanis-Tsakonas
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
Strain
Attribute String: mutant strain, targeted mutation, coisogenic
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Silvia Fre
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Joutel A
Year: 2010
Journal: J Clin Invest
Title: Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease.
Volume: 120
Issue: 2
Pages: 433-45
Publication
First Author: Dabertrand F
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease.
Volume: 112
Issue: 7
Pages: E796-805
Publication  
First Author: Klein C
Year: 2017
Journal: Sci Rep
Title: Stimulation of adult hippocampal neurogenesis by physical exercise and enriched environment is disturbed in a CADASIL mouse model.
Volume: 7
Pages: 45372
HT Experiment
Series Id: GSE58244
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Transgene
Type: transgene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
Strain
Attribute String: targeted mutation, mutant strain, coisogenic
Strain
Attribute String: mutant stock, targeted mutation
Publication  
First Author: Rosehart AC
Year: 2021
Journal: Front Aging Neurosci
Title: Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases.
Volume: 13
Pages: 695965
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Protein
Organism: Mus musculus/domesticus
Length: 2318  
Fragment?: false
Publication  
First Author: Liu XY
Year: 2015
Journal: Neurobiol Dis
Title: Stem cell factor and granulocyte colony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL.
Volume: 73
Pages: 189-203
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
Publication
First Author: Lacombe P
Year: 2005
Journal: Stroke
Title: Impaired cerebral vasoreactivity in a transgenic mouse model of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy arteriopathy.
Volume: 36
Issue: 5
Pages: 1053-8
Publication
First Author: Dubroca C
Year: 2005
Journal: Stroke
Title: Impaired vascular mechanotransduction in a transgenic mouse model of CADASIL arteriopathy.
Volume: 36
Issue: 1
Pages: 113-7
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
Allele
Name: transgene insertion 1, Elisabeth Tournier-Lasserve
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Elisabeth Tournier-Lasserve
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1217  
Fragment?: false
Publication  
First Author: Koch U
Year: 2020
Journal: J Exp Med
Title: A third Notch in colorectal cancer progression and metastasis.
Volume: 217
Issue: 10
Publication    
First Author: Capone C
Year: 2016
Journal: Elife
Title: Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Volume: 5
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Notch3/Notch3 Tg(Tagln-cre)1Her/?
Background: involves: 129 * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Protein
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1135  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
Publication
First Author: Nam Y
Year: 2006
Journal: Cell
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Volume: 124
Issue: 5
Pages: 973-83
Publication
First Author: Kovall RA
Year: 2008
Journal: Oncogene
Title: More complicated than it looks: assembly of Notch pathway transcription complexes.
Volume: 27
Issue: 38
Pages: 5099-109
Publication
First Author: McElhinny AS
Year: 2008
Journal: Oncogene
Title: Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways.
Volume: 27
Issue: 38
Pages: 5138-47
Publication
First Author: Shen H
Year: 2006
Journal: Genes Dev
Title: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Volume: 20
Issue: 6
Pages: 675-88
Publication
First Author: Zhao Y
Year: 2007
Journal: J Biol Chem
Title: The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Volume: 282
Issue: 16
Pages: 11969-81
Publication
First Author: Alves-Guerra MC
Year: 2007
Journal: Cancer Res
Title: Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival.
Volume: 67
Issue: 18
Pages: 8690-8
Publication
First Author: Chiang MY
Year: 2006
Journal: Mol Cell Biol
Title: Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Volume: 26
Issue: 16
Pages: 6261-71
Publication
First Author: Wu L
Year: 2007
Journal: Blood
Title: The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development.
Volume: 110
Issue: 10
Pages: 3618-23
Publication
First Author: Wu L
Year: 2005
Journal: EMBO J
Title: Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Volume: 24
Issue: 13
Pages: 2391-402
Publication
First Author: Fryer CJ
Year: 2004
Journal: Mol Cell
Title: Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Volume: 16
Issue: 4
Pages: 509-20
Publication
First Author: Wu L
Year: 2002
Journal: Mol Cell Biol
Title: Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
Volume: 22
Issue: 21
Pages: 7688-700
Publication  
First Author: Cameron B
Year: 2021
Journal: Biol Open
Title: Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.
Volume: 10
Issue: 9
Publication
First Author: Felli MP
Year: 2005
Journal: Oncogene
Title: PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.
Volume: 24
Issue: 6
Pages: 992-1000
Publication
First Author: Talora C
Year: 2003
Journal: EMBO Rep
Title: Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.
Volume: 4
Issue: 11
Pages: 1067-72
Publication
First Author: Kared H
Year: 2006
Journal: Immunity
Title: Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling.
Volume: 25
Issue: 5
Pages: 823-34
Publication
First Author: Zhu MY
Year: 2013
Journal: Gene Expr Patterns
Title: The expression of NOTCH2, HES1 and SOX9 during mouse retinal development.
Volume: 13
Issue: 3-4
Pages: 78-83
Publication
First Author: Gu B
Year: 2013
Journal: Cell Stem Cell
Title: Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.
Volume: 13
Issue: 1
Pages: 48-61
Publication
First Author: Low S
Year: 2018
Journal: Stem Cells
Title: Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells.
Volume: 36
Issue: 3
Pages: 458-466
Publication
First Author: Pang J
Year: 2021
Journal: Cell Rep
Title: NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression.
Volume: 34
Issue: 2
Pages: 108603
Publication
First Author: Gopinath SD
Year: 2014
Journal: Stem Cell Reports
Title: FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal.
Volume: 2
Issue: 4
Pages: 414-26
Protein
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 826  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
Publication
First Author: Fryer CJ
Year: 2002
Journal: Genes Dev
Title: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex.
Volume: 16
Issue: 11
Pages: 1397-411
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Protein Domain
Type: Family
Description: This family includes the neurogenic mastermind-like proteins 1-3 (MAML1-3) from chordates, which act as critical transcriptional co-activators for Notch signaling [, ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.They consist of an N-terminal domain which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors [, ]]. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Protein Domain
Type: Domain
Description: This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [, , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a functional DNA-binding complex with the cleaved Notch receptor and the transcription factor CSL, thereby regulating transcriptional events that are specific to the Notch pathway. MAML proteins may also play roles as key transcriptional co-activators in other signal transduction pathways as well, including: muscle differentiation and myopathies (MEF2C) [], tumour suppressor pathway (p53) []and colon carcinoma survival (beta-catenin) []. MAML proteins could mediate cross-talk among the various signaling pathways and the diverse activities of the MAML proteins converge to impact normal biological processes and human diseases, including cancers.The N-terminal domain of MAML proteins adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors []. This N-terminal domain is responsible for its interaction with the ankyrin repeat region of the Notch proteins NOTCH1 [], NOTCH2 [], NOTCH3 []and NOTCH4. It forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1, and also binds CREBBP/CBP []and CDK8 []. The C-terminal region is required for transcriptional activation.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1210  
Fragment?: false