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Details |
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| First Author: |
Aoyama M |
| Year: |
2012 |
| Journal: |
Dev Cell |
| Title: |
Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway. |
| Volume: |
22 |
| Issue: |
6 |
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1163-75 |
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| First Author: |
Tong Y |
| Year: |
2017 |
| Journal: |
FEBS Lett |
| Title: |
An essential role of intestinal cell kinase in lung development is linked to the perinatal lethality of human ECO syndrome. |
| Volume: |
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9 |
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| First Author: |
Rasile M |
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2022 |
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EMBO J |
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Maternal immune activation leads to defective brain-blood vessels and intracerebral hemorrhages in male offspring. |
| Volume: |
41 |
| Issue: |
23 |
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e111192 |
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| First Author: |
Weberling A |
| Year: |
2025 |
| Journal: |
iScience |
| Title: |
Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation. |
| Volume: |
28 |
| Issue: |
1 |
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111671 |
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•
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| First Author: |
European Mouse Mutant Archive |
| Year: |
2003 |
| Journal: |
Unpublished |
| Title: |
Information obtained from the European Mouse Mutant Archive (EMMA) |
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•
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| First Author: |
Somekawa S |
| Year: |
2012 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. |
| Volume: |
109 |
| Issue: |
30 |
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12064-9 |
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•
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| First Author: |
Tomann P |
| Year: |
2016 |
| Journal: |
Development |
| Title: |
Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth. |
| Volume: |
143 |
| Issue: |
9 |
| Pages: |
1512-22 |
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| First Author: |
Yuan G |
| Year: |
2015 |
| Journal: |
Development |
| Title: |
The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development. |
| Volume: |
142 |
| Issue: |
1 |
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128-39 |
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| First Author: |
Iyer S |
| Year: |
2016 |
| Journal: |
Sci Rep |
| Title: |
Crim1 has cell-autonomous and paracrine roles during embryonic heart development. |
| Volume: |
6 |
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19832 |
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| First Author: |
Kurbet AS |
| Year: |
2016 |
| Journal: |
Cell Rep |
| Title: |
Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin. |
| Volume: |
16 |
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12 |
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| First Author: |
Fu Y |
| Year: |
2021 |
| Journal: |
Mol Cell |
| Title: |
OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. |
| Volume: |
81 |
| Issue: |
15 |
| Pages: |
3187-3204.e7 |
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| First Author: |
Li D |
| Year: |
2011 |
| Journal: |
Hum Mol Genet |
| Title: |
Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. |
| Volume: |
20 |
| Issue: |
23 |
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4582-96 |
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| First Author: |
Yang J |
| Year: |
2021 |
| Journal: |
Sci Signal |
| Title: |
Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation. |
| Volume: |
14 |
| Issue: |
665 |
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| First Author: |
McKean DM |
| Year: |
2012 |
| Journal: |
Biol Open |
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Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. |
| Volume: |
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| Issue: |
9 |
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Reyahi A |
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2015 |
| Journal: |
Dev Cell |
| Title: |
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier. |
| Volume: |
34 |
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1 |
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| First Author: |
Portal C |
| Year: |
2019 |
| Journal: |
Elife |
| Title: |
Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse. |
| Volume: |
8 |
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| First Author: |
Kumar S |
| Year: |
2023 |
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JCI Insight |
| Title: |
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis. |
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8 |
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1 |
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Neupane S |
| Year: |
2022 |
| Journal: |
Matrix Biol |
| Title: |
O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. |
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107 |
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Golonzhka O |
| Year: |
2015 |
| Journal: |
Neuron |
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Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons. |
| Volume: |
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| First Author: |
Grieskamp T |
| Year: |
2011 |
| Journal: |
Circ Res |
| Title: |
Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. |
| Volume: |
108 |
| Issue: |
7 |
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| First Author: |
Flodby P |
| Year: |
2016 |
| Journal: |
Am J Respir Cell Mol Biol |
| Title: |
The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. |
| Volume: |
55 |
| Issue: |
1 |
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135-49 |
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| First Author: |
Zhang R |
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2013 |
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J Biol Chem |
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Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. |
| Volume: |
288 |
| Issue: |
15 |
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| First Author: |
Landry J |
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2008 |
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PLoS Genet |
| Title: |
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. |
| Volume: |
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10 |
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Vezzali R |
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2016 |
| Journal: |
Oncotarget |
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The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. |
| Volume: |
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| Issue: |
25 |
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37436-37455 |
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| First Author: |
Choe Y |
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2012 |
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Neuron |
| Title: |
A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. |
| Volume: |
73 |
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698-712 |
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Cases O |
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2013 |
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J Biol Chem |
| Title: |
Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. |
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288 |
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Seth A |
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2014 |
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Development |
| Title: |
Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. |
| Volume: |
141 |
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3 |
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538-47 |
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BMC Biol |
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Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate. |
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J Biol Chem |
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Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia. |
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Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. |
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Oxburgh L |
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2004 |
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TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. |
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Koutelou E |
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USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta. |
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BMC Immunol |
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Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. |
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Shanghai Model Organisms Center |
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MGI Direct Data Submission |
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Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Strain |
| Attribute String: |
mutant stock, targeted mutation |
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| Publication |
| First Author: |
Franquinho F |
| Year: |
2017 |
| Journal: |
Cereb Cortex |
| Title: |
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling. |
| Volume: |
27 |
| Issue: |
3 |
| Pages: |
1732-1747 |
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•
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| Publication |
| First Author: |
Chen H |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
3616 |
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| Strain |
| Attribute String: |
targeted mutation, mutant strain, Not Applicable |
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| Publication |
| First Author: |
Tang YN |
| Year: |
2015 |
| Journal: |
Nat Commun |
| Title: |
Epigenetic regulation of Smad2 and Smad3 by profilin-2 promotes lung cancer growth and metastasis. |
| Volume: |
6 |
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| Pages: |
8230 |
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| Publication |
| First Author: |
Hosokawa R |
| Year: |
2005 |
| Journal: |
J Invest Dermatol |
| Title: |
Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. |
| Volume: |
125 |
| Issue: |
6 |
| Pages: |
1302-9 |
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| Publication |
| First Author: |
Hoover LL |
| Year: |
2008 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. |
| Volume: |
1783 |
| Issue: |
12 |
| Pages: |
2279-86 |
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| Publication |
| First Author: |
Dai J |
| Year: |
2020 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Osteoclast-derived exosomal let-7a-5p targets Smad2 to promote the hypertrophic differentiation of chondrocytes. |
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| Publication |
| First Author: |
Zhao J |
| Year: |
1998 |
| Journal: |
Dev Biol |
| Title: |
Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture. |
| Volume: |
194 |
| Issue: |
2 |
| Pages: |
182-95 |
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| Interaction Experiment |
| Description: |
Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation. |
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| Interaction Experiment |
| Description: |
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2. |
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| GO Term |
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| Publication |
| First Author: |
Tsukazaki T |
| Year: |
1998 |
| Journal: |
Cell |
| Title: |
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. |
| Volume: |
95 |
| Issue: |
6 |
| Pages: |
779-91 |
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| Publication |
| First Author: |
Wu G |
| Year: |
2000 |
| Journal: |
Science |
| Title: |
Structural basis of Smad2 recognition by the Smad anchor for receptor activation. |
| Volume: |
287 |
| Issue: |
5450 |
| Pages: |
92-7 |
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| Publication |
| First Author: |
Shathasivam P |
| Year: |
2015 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling. |
| Volume: |
112 |
| Issue: |
23 |
| Pages: |
E3000-9 |
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| DO Term |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
467
 |
| Fragment?: |
false |
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| Allele |
| Name: |
SMAD family member 2; targeted mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
437
 |
| Fragment?: |
false |
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| GO Term |
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| Publication |
| First Author: |
Bernard DJ |
| Year: |
2004 |
| Journal: |
Mol Endocrinol |
| Title: |
Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
606-23 |
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| Publication |
| First Author: |
Lin F |
| Year: |
2005 |
| Journal: |
Hum Mol Genet |
| Title: |
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling. |
| Volume: |
14 |
| Issue: |
3 |
| Pages: |
437-45 |
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| Publication |
| First Author: |
Kuratomi G |
| Year: |
2005 |
| Journal: |
Biochem J |
| Title: |
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor. |
| Volume: |
386 |
| Issue: |
Pt 3 |
| Pages: |
461-70 |
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| Allele |
| Name: |
transgene insertion, Joanna E Burdette |
| Allele Type: |
Transgenic |
| Attribute String: |
Dominant negative, Inserted expressed sequence |
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| Allele |
| Name: |
SMAD family member 2; targeted mutation 6, Elizabeth Robertson |
| Allele Type: |
Targeted |
| Attribute String: |
Inserted expressed sequence |
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