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Search results 1301 to 1400 out of 1497 for Mitf

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1903271
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3273519
Pattern: Punctate
Stage: TS19
Assay Id: MGI:4437016
Age: embryonic day 11.5
Note: The density of expressing melanoblasts is reduced.
Specimen Label: 3 Mitf Mi/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1903271
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437016
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/Mi
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:4437020
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437021
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/+
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4437020
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437021
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/Mi
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1905244
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437029
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/+
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1905244
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437029
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/Mi
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4437036
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437035
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/+
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4437036
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437035
Age: embryonic day 11.5
Specimen Label: 3 Mitf Mi/Mi
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3793667
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437038
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/Mi
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3793667
Assay Type: RNA in situ
Annotation Date: 2010-03-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3273519
Stage: TS19
Assay Id: MGI:4437038
Age: embryonic day 11.5
Note: Absent in melanoblasts.
Specimen Label: 3 Mitf Mi/+
Detected: false
Specimen Num: 2
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Allele
Mitf<Rorp> | MGI:2178357
Name: melanogenesis associated transcription factor; retinal orange patches
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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GXD Expression
GXD Expression
Probe: MGI:2385688
Assay Type: RNA in situ
Annotation Date: 2017-06-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1675019
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:5898553
Age: embryonic day 11.5
Image: 3C
Note: Overlap of Mitf and Dct expression away from midline.
Specimen Label: 3C
Detected: true
Specimen Num: 3
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Publication
9499424 | J:46819
First Author: Hodgkinson CA
Year: 1998
Journal: Hum Mol Genet
Title: Mutation at the anophthalmic white locus in Syrian hamsters: haploinsufficiency in the Mitf gene mimics human Waardenburg syndrome type 2.
Volume: 7
Issue: 4
Pages: 703-8
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Protein Coding Gene
MGI:104638 | Tff3
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Mitf<tm1.2Arnh> | MGI:3774164
Name: melanogenesis associated transcription factor; targeted mutation 1.2, Heinz Arnheiter
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: hm
Has Mutant Allele: true
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Interaction Experiment
Schwarz T (2010)
Description: The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.
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Publication
15507434 | -
First Author: Miller AJ
Year: 2005
Journal: J Biol Chem
Title: Sumoylation of MITF and its related family members TFE3 and TFEB.
Volume: 280
Issue: 1
Pages: 146-55
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Protein
Q9QUJ6
Organism: Mus musculus/domesticus
Length: 371  
Fragment?: false
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0090100 | ocular albinism with sensorineural deafness
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Allele
Mitf<Mi> | MGI:1856085
 
Name: melanogenesis associated transcription factor; microphthalmia
Allele Type: Other
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Allele
Mitf<Mi-wh> | MGI:1856088
 
Name: melanogenesis associated transcription factor; white
Allele Type: Spontaneous
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Allele
Mitf<mi-enu122> | MGI:1857751
 
Name: melanogenesis associated transcription factor; microphthalmia enu 122
Allele Type: Chemically induced (ENU)
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Allele
Mitf<Mi-H> | MGI:2178353
 
Name: melanogenesis associated transcription factor; microphthalmia Harwell
Allele Type: Chemically induced (ENU)
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Allele
Mitf<mi-x> | MGI:2662152
 
Name: melanogenesis associated transcription factor; microphthalmia x
Allele Type: Spontaneous
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Publication
16605125 | -
 
First Author: Kitamura Y
Year: 2005
Journal: Novartis Found Symp
Title: MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells.
Volume: 271
Pages: 4-11; discussion 11-4, 95-9
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Publication
14975237 | -
First Author: Lee YN
Year: 2004
Journal: Immunity
Title: The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.
Volume: 20
Issue: 2
Pages: 145-51
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Publication
11955610 | -
First Author: Takeda K
Year: 2002
Journal: Biochim Biophys Acta
Title: Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations.
Volume: 1574
Issue: 1
Pages: 15-23
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HT Experiment
GSE227055 | A framework to identify functional interactors that contribute to disrupted early retinal development in Vsx2 mutant mice III
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Mitf<mi-bw> | MGI:1856089
 
Name: melanogenesis associated transcription factor; black eyed white
Allele Type: Spontaneous
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Allele
Mitf<Mi-Crc> | MGI:2662140
 
Name: melanogenesis associated transcription factor; microphthalmia MRC Clinical Research Centre
Allele Type: Spontaneous
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: CBA/CaCrc
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: NZB/Mac
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: BALB/cAnN * C3H/HeN
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: C57BL * DBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: C57BL * DBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: NZB/Mac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: 102 * C3H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: 102 * C3H
Zygosity: ht
Has Mutant Allele: true
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Allele
Mitf<mi-tg> | MGI:1858053
 
Name: melanogenesis associated transcription factor; microphthalmia transgene insertion
Allele Type: Transgenic
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Strain
MGI:5142438 | STOCK Mitf<Rorp>/H
Attribute String: chemically induced mutation, mutant stock
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Allele
Mitf<mi-vga9> | MGI:2449916
 
Name: melanogenesis associated transcription factor; transgenic insertion 9
Allele Type: Transgenic
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Allele
Mitf<tm1.1(cre)Mwka> | MGI:6151122
Name: melanogenesis associated transcription factor; targeted mutation 1.1, Mari Wataya-Kaneda
Allele Type: Targeted
Attribute String: Recombinase
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Allele
Mitf<mi-ew> | MGI:1856094
 
Name: melanogenesis associated transcription factor; eyeless white
Allele Type: Spontaneous
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: CBA/CaCrc
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf Tg(Dct-lacZ)A12Jkn/?
Background: involves: C3H * C57BL/6 * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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DO Term
DOID:0110950 | Waardenburg syndrome type 2A
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DO Term
DOID:0090002 | Tietz syndrome
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Strain
MGI:4357676 | B6.Cg-Mitf<mi-tg>
Attribute String: congenic, insertion, mutant strain, transgenic
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: B6.Cg-Mitf
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf<+>
Background: involves: C3H/HeNCrl * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: C3H/HeNCrl * C57BL/6NCrl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf Tfe3/Tfe3
Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: 129S1/Sv * C57BL/6 * NAW
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: C57BL/6Bn * NAW
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf Tfe3/Tfe3<+>
Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: C57BL/6Bn
Zygosity: hm
Has Mutant Allele: true
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Publication
9806910 | J:50513
First Author: Steingrímsson E
Year: 1998
Journal: Development
Title: The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.
Volume: 125
Issue: 23
Pages: 4607-16
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Allele
Tg(Mitf-cre)710-59Gsb | MGI:3778683
Name: transgene insertion 710-59, Gregory S Barsh
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Mitf-cre)7114Gsb | MGI:3778684
Name: transgene insertion 7114, Gregory S Barsh
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Mitf<mi-enu22(398)> | MGI:6162028
Name: melanogenesis associated transcription factor; microphthalmia enu 22(398)
Allele Type: Chemically induced (ENU)
Attribute String: Null/knockout
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Publication
11818452 | -
First Author: Mansky KC
Year: 2002
Journal: J Leukoc Biol
Title: The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.
Volume: 71
Issue: 2
Pages: 304-10
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Protein
Q3TZX0
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
A0A0J9YTW5
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
8336698 | J:53285
First Author: Zhao GQ
Year: 1993
Journal: Mol Cell Biol
Title: TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
Volume: 13
Issue: 8
Pages: 4505-12
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Protein Domain
IPR024101 | TFEC
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').This entry represents transcription factor EC (TFEC). TFEC can act as a repressor or an activator. It acts as a transcriptional repressor on minimal promoter containing muE3 enhancer sequence []and as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter []. It binds DNA in a homo or heterodimeric form with MITF and TFE3.
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Protein
D3Z219
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: true
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Publication
23159739 | -
First Author: Ofir-Birin Y
Year: 2013
Journal: Mol Cell
Title: Structural switch of lysyl-tRNA synthetase between translation and transcription.
Volume: 49
Issue: 1
Pages: 30-42
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Protein Domain
IPR031867 | MiT/TFE_N
Type: Domain
Description: This entry represents a domain found at the N terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC []. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription factors heterodimerize with each other and bind to the E-box core sequence (3'-CANNTG-5') [, ].
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Protein Domain
IPR031889 | AIMP2_LysRS-bd
Type: Domain
Description: This entry represents the lysyl-tRNA synthetase (LysRS) binding domain of AIMP2 (aminoacyl tRNA synthase complex-interacting multifunctional protein 2). LysRS can serve as a transcription regulator that can be released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the transcription factor MITF in stimulated mast cells. In quiescent cells, LysRS is held in the MSC via its interactions with AIMP2 [].
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Protein Domain
IPR021802 | MiT/TFE_C
Type: Domain
Description: This entry represents a domain found at the C terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC []. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription factors heterodimerize with each other and bind to the E-box core sequence (3'-CANNTG-5') [, ].
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Strain
MGI:5702900 | C3FeJ.Cg-Tg(Mitf-cre)7114Gsb
Attribute String: transgenic, mutant strain, congenic
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Strain
MGI:6423890 | B6.Cg-Mitf<mi-enu22(398)>/Kctt
Attribute String: congenic, mutant strain, chemically induced mutation
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Strain
MGI:6474345 | C57BL/6J-Mitf<mi-enu22(398)Is>/Mmmh
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Genotype
Genotype
Symbol: Mitf/Mitf Tfe3/Tfe3
Background: either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Tg(Mitf-cre)7114Gsb
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Protein
E9PWJ9
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
D3Z782
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
Q60982
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
D3YZM7
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
D3Z1X9
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
E9PXZ1
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Publication
26240184 | -
First Author: Nezich CL
Year: 2015
Journal: J Cell Biol
Title: MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.
Volume: 210
Issue: 3
Pages: 435-50
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Strain
MGI:6187661 | C3FeJ.Cg-Adamts9<tm1.1Cvrk> Tg(Mitf-cre)7114Gsb
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Allele
Mitf<Tg(Tff3-Tmem207)2Tamo> | MGI:6287154
Name: melanogenesis associated transcription factor; transgene insertion 2, Takeuchi Tamotsu
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Mitf/Mitf
Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Adamts9/Adamts9 Tg(Mitf-cre)7114Gsb/?
Background: C3FeJ.Cg-Adamts9 Tg(Mitf-cre)7114Gsb
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rps6/Rps6<+> Tg(Mitf-cre)7114Gsb/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR024098 | TFEB
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity []. It also plays a role in the signal transduction processes required for normal vascularisation of the placenta [].
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Publication
27261482 | J:236808
First Author: Virós A
Year: 2016
Journal: Cancer Discov
Title: So You Can Teach Old Fibroblasts New Tricks.
Volume: 6
Issue: 6
Pages: 581-3
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Publication
16936731 | J:112628
First Author: Huan C
Year: 2006
Journal: Nat Immunol
Title: Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.
Volume: 7
Issue: 10
Pages: 1082-91
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Protein
Q8K420
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein
A2AEW2
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Strain
MGI:3828511 | B6.Cg-Mitf<mi-sp> Mitf<mi-vga9>/Mmmh
Attribute String: congenic, spontaneous mutation, transgenic, insertion, deletion
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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