| Type |
Details |
Score |
| Publication |
| First Author: |
Santeford A |
| Year: |
2016 |
| Journal: |
Autophagy |
| Title: |
Impaired autophagy in macrophages promotes inflammatory eye disease. |
| Volume: |
12 |
| Issue: |
10 |
| Pages: |
1876-1885 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lamkanfi M |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. |
| Volume: |
187 |
| Issue: |
1 |
| Pages: |
61-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Case CL |
| Year: |
2013 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. |
| Volume: |
110 |
| Issue: |
5 |
| Pages: |
1851-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Briard B |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
Galactosaminogalactan activates the inflammasome to provide host protection. |
| Volume: |
588 |
| Issue: |
7839 |
| Pages: |
688-692 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kinsella RL |
| Year: |
2023 |
| Journal: |
PLoS Biol |
| Title: |
Autophagy prevents early proinflammatory responses and neutrophil recruitment during Mycobacterium tuberculosis infection without affecting pathogen burden in macrophages. |
| Volume: |
21 |
| Issue: |
6 |
| Pages: |
e3002159 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Vasconcelos NM |
| Year: |
2020 |
| Journal: |
Cell Rep |
| Title: |
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages. |
| Volume: |
32 |
| Issue: |
4 |
| Pages: |
107959 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng Y |
| Year: |
2011 |
| Journal: |
PLoS Pathog |
| Title: |
A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. |
| Volume: |
7 |
| Issue: |
4 |
| Pages: |
e1002026 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Orlowski GM |
| Year: |
2017 |
| Journal: |
J Leukoc Biol |
| Title: |
Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation. |
| Volume: |
102 |
| Issue: |
1 |
| Pages: |
7-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dang EV |
| Year: |
2017 |
| Journal: |
Cell |
| Title: |
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. |
| Volume: |
171 |
| Issue: |
5 |
| Pages: |
1057-1071.e11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allam R |
| Year: |
2014 |
| Journal: |
EMBO Rep |
| Title: |
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming. |
| Volume: |
15 |
| Issue: |
9 |
| Pages: |
982-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang D |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. |
| Volume: |
43 |
| Issue: |
5 |
| Pages: |
923-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan Q |
| Year: |
2007 |
| Journal: |
J Leukoc Biol |
| Title: |
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. |
| Volume: |
82 |
| Issue: |
1 |
| Pages: |
177-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Toma C |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. |
| Volume: |
184 |
| Issue: |
9 |
| Pages: |
5287-97 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gong T |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders. |
| Volume: |
198 |
| Issue: |
5 |
| Pages: |
2082-2092 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2008 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. |
| Volume: |
181 |
| Issue: |
1 |
| Pages: |
17-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Griewahn L |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD. |
| Volume: |
42 |
| Issue: |
1 |
| Pages: |
111961 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zheng TS |
| Year: |
2000 |
| Journal: |
Exp Cell Res |
| Title: |
Divinations and surprises: genetic analysis of caspase function in mice. |
| Volume: |
256 |
| Issue: |
1 |
| Pages: |
67-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jurisicova A |
| Year: |
1998 |
| Journal: |
Mol Reprod Dev |
| Title: |
Expression and regulation of genes associated with cell death during murine preimplantation embryo development. |
| Volume: |
51 |
| Issue: |
3 |
| Pages: |
243-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumar S |
| Year: |
1999 |
| Journal: |
Trends Biochem Sci |
| Title: |
Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis. |
| Volume: |
24 |
| Issue: |
1 |
| Pages: |
1-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Los M |
| Year: |
1999 |
| Journal: |
Immunity |
| Title: |
The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. |
| Volume: |
10 |
| Issue: |
6 |
| Pages: |
629-39 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dutra FF |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Hemolysis-induced lethality involves inflammasome activation by heme. |
| Volume: |
111 |
| Issue: |
39 |
| Pages: |
E4110-8 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
686
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
686
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kayagaki N |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
Non-canonical inflammasome activation targets caspase-11. |
| Volume: |
479 |
| Issue: |
7371 |
| Pages: |
117-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aachoui Y |
| Year: |
2013 |
| Journal: |
Science |
| Title: |
Caspase-11 protects against bacteria that escape the vacuole. |
| Volume: |
339 |
| Issue: |
6122 |
| Pages: |
975-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aachoui Y |
| Year: |
2015 |
| Journal: |
Cell Host Microbe |
| Title: |
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. |
| Volume: |
18 |
| Issue: |
3 |
| Pages: |
320-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu S |
| Year: |
2017 |
| Journal: |
Nature |
| Title: |
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. |
| Volume: |
546 |
| Issue: |
7660 |
| Pages: |
667-670 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Elinav E |
| Year: |
2011 |
| Journal: |
Cell |
| Title: |
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. |
| Volume: |
145 |
| Issue: |
5 |
| Pages: |
745-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McKee AS |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. |
| Volume: |
183 |
| Issue: |
7 |
| Pages: |
4403-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huber S |
| Year: |
2012 |
| Journal: |
Nature |
| Title: |
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. |
| Volume: |
491 |
| Issue: |
7423 |
| Pages: |
259-63 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Bossaller L |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. |
| Volume: |
189 |
| Issue: |
12 |
| Pages: |
5508-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dupaul-Chicoine J |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity. |
| Volume: |
43 |
| Issue: |
4 |
| Pages: |
751-63 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Hepworth MR |
| Year: |
2015 |
| Journal: |
Science |
| Title: |
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. |
| Volume: |
348 |
| Issue: |
6238 |
| Pages: |
1031-5 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Gurung P |
| Year: |
2016 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis. |
| Volume: |
113 |
| Issue: |
16 |
| Pages: |
4452-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hai Q |
| Year: |
2018 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant. |
| Volume: |
38 |
| Issue: |
1 |
| Pages: |
83-91 |
|
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•
•
•
•
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| Publication |
| First Author: |
Malireddi RKS |
| Year: |
2018 |
| Journal: |
J Exp Med |
| Title: |
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. |
| Volume: |
215 |
| Issue: |
4 |
| Pages: |
1023-1034 |
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•
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| First Author: |
Ataide MA |
| Year: |
2014 |
| Journal: |
PLoS Pathog |
| Title: |
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
e1003885 |
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•
•
•
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| First Author: |
Kastenmüller W |
| Year: |
2012 |
| Journal: |
Cell |
| Title: |
A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. |
| Volume: |
150 |
| Issue: |
6 |
| Pages: |
1235-48 |
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| First Author: |
Yang J |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity. |
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| First Author: |
Kumar SRP |
| Year: |
2024 |
| Journal: |
Mol Ther |
| Title: |
TLR9-independent CD8(+) T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling. |
| Volume: |
32 |
| Issue: |
2 |
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325-339 |
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| First Author: |
Scagnolari C |
| Year: |
2020 |
| Journal: |
J Virol |
| Title: |
Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice. |
| Volume: |
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12 |
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| First Author: |
Anthony DA |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
A role for granzyme M in TLR4-driven inflammation and endotoxicosis. |
| Volume: |
185 |
| Issue: |
3 |
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| First Author: |
Miao EA |
| Year: |
2010 |
| Journal: |
Nat Immunol |
| Title: |
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. |
| Volume: |
11 |
| Issue: |
12 |
| Pages: |
1136-42 |
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| First Author: |
Maltez VI |
| Year: |
2015 |
| Journal: |
Immunity |
| Title: |
Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. |
| Volume: |
43 |
| Issue: |
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Kovacs SB |
| Year: |
2020 |
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Cell Rep |
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. |
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Coers J |
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Cell Microbiol |
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Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. |
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Kitamoto S |
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2020 |
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Cell |
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The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. |
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Burke TP |
| Year: |
2020 |
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Nat Microbiol |
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Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis. |
| Volume: |
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Shimada K |
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PLoS One |
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Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection. |
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Nat Commun |
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Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. |
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Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node. |
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2020 |
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Nat Microbiol |
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Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. |
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The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent. |
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