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Search results 1501 to 1600 out of 1654 for Mecp2

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Type Details Score
Genotype
Genotype
Symbol: Tg(MECP2)3Hzo/?
Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt
Background: B6.Cg-Mapt
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
GSE67294 | Length-dependent gene misregulation in Rett syndrome (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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DO Term
DOID:0060827 | X-linked intellectual disability-psychosis-macroorchidism syndrome
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Allele
Mecp2<tm2Qcha> | MGI:7264415
Name: methyl CpG binding protein 2; targeted mutation 2, Qiang Chang
Allele Type: Targeted
Attribute String: Epitope tag
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HT Experiment
E-GEOD-33457 | Amygdalar gene expression from Mecp2-null and MECP2-transgenic mice
Series Id: GSE33457
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-59029 | Quantitative analysis of wild type and MeCP2-/y mice hippocampus miRNAs using next generation sequencing
Series Id: GSE59029
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE60219 | Transcriptional landscape of different brain regions in a Rett syndrome mouse model
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
17046689 | -
First Author: Zhou Z
Year: 2006
Journal: Neuron
Title: Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.
Volume: 52
Issue: 2
Pages: 255-69
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Publication
10518942 | -
First Author: Wakefield RI
Year: 1999
Journal: J Mol Biol
Title: The solution structure of the domain from MeCP2 that binds to methylated DNA.
Volume: 291
Issue: 5
Pages: 1055-65
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Publication
17584923 | -
 
First Author: Jordan C
Year: 2007
Journal: BMC Med Genet
Title: Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets.
Volume: 8
Pages: 36
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Allele
Tg(MECP2)1Hzo | MGI:3815540
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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HT Experiment
E-GEOD-11150 | Hypothalamic gene expression data from Mecp2-null and MECP2-transgenic mice
Series Id: GSE11150
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-43689 | Long non-coding RNAs expression study of a Rett syndrome mouse model
Series Id: GSE43689
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Rr295<em1Hzo> | MGI:7356640
Name: regulatory region 295; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Mecp2<tm1Qcha> | MGI:7264414
Name: methyl CpG binding protein 2; targeted mutation 1, Qiang Chang
Allele Type: Targeted
Attribute String: Epitope tag, Modified isoform(s)
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Publication
25870282 | -
First Author: Chen L
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome.
Volume: 112
Issue: 17
Pages: 5509-14
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HT Experiment
GSE221361 | A single-cell atlas reveals heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE66211 | Mecp2: an unexpected regulator of macrophage gene expression and function [RNA-Seq]
Series Id: E-GEOD-66211
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(MECP2/EGFP)1Hzo | MGI:5588443
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Rr296<em1Hzo> | MGI:7356641
Name: regulatory region 296; endonuclease-mediated mutation 1, Huda Y Zoghbi
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Allele
Tg(MECP2*R270X/GFP)AHzo | MGI:5491036
Name: transgene insertion A, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Mecp2<tm1Bdlv> | MGI:6444751
Name: methyl CpG binding protein 2; targeted mutation 1, Antonio Bedalov
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Protein Domain
IPR045138 | MeCP2/MBD4
Type: Family
Description: Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [, ]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifications []. Mecp2 is required for proper mitotic spindle organisation []and affects proliferation and apoptosis []. Mutations in MeCP2 gene cause an X-linked neurodevelopmental disease known as Rett syndrome [].Methyl-CpG-binding domain protein 4 (MBD4) is a mismatch-specific DNA N-glycosylase involved in DNA repair. It has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites [, ].
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HT Experiment
E-GEOD-11596 | Gene expression profiles of wild type and Mecp2-null mice in three different regions of the brain
Series Id: GSE11596
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Transgene
MGI:3815538 | Tg(MECP2)3Hzo
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:3815539 | Tg(MECP2)1Hzo
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(MECP2)1Hzo/?
Background: either: (FVB/N x 129S6/SvEvTac)F1 or (FVB/N x C57BL/6J)F1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MECP2)1Hzo/?
Background: FVB-Tg(MECP2)1Hzo/J
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-42987 | Hippocampal expression data from WT, KO, R270X, and G273X mice at 4 and 9 weeks
Series Id: GSE42987
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:5588438 | FVB/N-Tg(MECP2/EGFP)1Hzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6471040 | FVB/N-Tg(MECP2*R270X/GFP)AHzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Tg(MECP2*R270X/GFP)AHzo/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr295/Rr295
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rr296/Rr296
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
31133783 | J:280973
 
First Author: Zhou C
Year: 2019
Journal: Front Neurosci
Title: Atypical Response Properties of the Auditory Cortex of Awake MECP2-Overexpressing Mice.
Volume: 13
Pages: 439
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Protein Coding Gene
MGI:1314872 | Hipk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9QZR5
Organism: Mus musculus/domesticus
Length: 1196  
Fragment?: false
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Protein
Q3UGS3
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
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Protein
A0A0N4SV30
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Publication
10930409 | -
First Author: Petronzelli F
Year: 2000
Journal: J Biol Chem
Title: Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase.
Volume: 275
Issue: 42
Pages: 32422-9
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Protein Coding Gene
MGI:2138281 | Lbr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107157 | Sin3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q3U9G9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q60520
Organism: Mus musculus/domesticus
Length: 1274  
Fragment?: false
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Strain
MGI:3817213 | FVB-Tg(MECP2)3Hzo/J
Attribute String: transgenic, coisogenic
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Allele
Tg(MECP2*R111G/EGFP)1Hzo | MGI:5588460
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(MECP2*R306C/EGFP)1Hzo | MGI:5588452
Name: transgene insertion 1, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Mecp2<tm5.1Joez> | MGI:5896330
Name: methyl CpG binding protein 2; targeted mutation 5.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, No functional change
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Allele
Tg(MECP2*G273X/GFP)AHzo | MGI:5491039
Name: transgene insertion A, Huda Y Zoghbi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Tg(MECP2)3Hzo/?
Background: involves: FVB
Zygosity: ot
Has Mutant Allele: true
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HT Experiment
E-GEOD-24320 | Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (high-throughput sequencing)
Series Id: GSE24320
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE113901 | Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing (Single-cell or single-nuclei RNA sequencing)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
23220634 | J:194417
First Author: Yang T
Year: 2012
Journal: Sci Transl Med
Title: Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses.
Volume: 4
Issue: 163
Pages: 163ra158
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Protein Coding Gene
MGI:1097691 | Hdac2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70288
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Strain
MGI:5427824 | B6.Cg-Mapt<tm1(Mecp2)Jae>/LimmJ
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5318993 | B6.Cg-Mapt<tm1(Mecp2)Jae>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5588441 | FVB/N-Tg(MECP2*R111G/EGFP)1Hzo/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:5588440 | FVB/N-Tg(MECP2*R306C/EGFP)1Hzo/J
Attribute String: transgenic, mutant strain, coisogenic
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Strain
MGI:7311652 | B6.129(FVB)-Mecp2<tm5.1Joez>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5896341 | B6.129(FVB)-Mecp2<tm5.1Joez>/J
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Mecp2<tm1.1Bird> | MGI:2137311
Name: methyl CpG binding protein 2; targeted mutation 1.1, Adrian Bird
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Mecp2<tm1.1Jtc> | MGI:5568206
Name: methyl CpG binding protein 2; targeted mutation 1.1, Joseph T Coyle
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Mecp2<tm3.1Joez> | MGI:5790795
Name: methyl CpG binding protein 2; targeted mutation 3.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, Humanized sequence
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Allele
Mecp2<tm4.1Joez> | MGI:5790796
Name: methyl CpG binding protein 2; targeted mutation 4.1, Zhaolan Zhou
Allele Type: Targeted
Attribute String: Epitope tag, Humanized sequence
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Strain
MGI:6471044 | FVB/N-Tg(MECP2*G273X/GFP)AHzo/J
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Mecp2<em7.1Bird> | MGI:6437877
Name: methyl CpG binding protein 2; endonuclease-mediated mutation 7.1, Adrian Bird
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Genotype
Genotype
Symbol: Mapt/Mapt
Background: involves: 129/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mapt/Mapt<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(MECP2*G273X/GFP)AHzo/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: B6.129(FVB)-Mecp2
Zygosity: ht
Has Mutant Allele: true
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HT Experiment
E-GEOD-32870 | Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome
Series Id: GSE32870
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-24286 | Genome-wide Analysis Reveals Mecp2-dependent Regulation of MicroRNAs in a Mouse Model of Rett Syndrome (mm8 promoter arrays)
Series Id: GSE24286
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Strain
MGI:2165230 | B6.129P2(C)-Mecp2<tm1.1Bird>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5568127 | STOCK Mecp2<tm1.1Jtc>/SchvJ
Attribute String: mutant stock, targeted mutation
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Strain
MGI:7311650 | B6.129(FVB)-Mecp2<tm3.1Joez>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5790798 | B6.129(FVB)-Mecp2<tm3.1Joez>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7311648 | B6.129(FVB)-Mecp2<tm4.1Joez>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5790799 | STOCK Mecp2<tm4.1Joez>/J
Attribute String: targeted mutation, mutant stock
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: involves: 129P2/OlaHsd
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: involves: 129S6/SvEvTac * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2
Background: involves: 129S6/SvEvTac * 129/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129S6/SvEvTac * 129/SvJ
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: B6.129P2(C)-Mecp2/J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: B6.129P2(C)-Mecp2/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * CD-1
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/?
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: B6.129(FVB)-Mecp2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mecp2/Mecp2<+>
Background: B6.129(FVB)-Mecp2
Zygosity: ht
Has Mutant Allele: true
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