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Search results 1601 to 1700 out of 1727 for Dcc

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Type Details Score
Publication
First Author: Li W
Year: 2004
Journal: Nat Neurosci
Title: Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Volume: 7
Issue: 11
Pages: 1213-21
Genotype
Symbol: Apc/Apc<+> Dcc/Dcc<+>
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Dcc/Dcc<+> Unc5c/Unc5c<+>
Background: involves: 129X1/SvJ * C57BL/6J * SJL/J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Schievenbusch S
Year: 2012
Journal: Stem Cells Dev
Title: Neighbor of Punc E 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development.
Volume: 21
Issue: 14
Pages: 2656-66
Publication
First Author: Meyerhardt JA
Year: 1997
Journal: Oncogene
Title: Identification and characterization of neogenin, a DCC-related gene.
Volume: 14
Issue: 10
Pages: 1129-36
Protein Domain
Type: Domain
Description: This entry represents the C terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites []. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of and ) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 3102  
Fragment?: false
Publication
First Author: Hagihara M
Year: 2011
Journal: J Biol Chem
Title: Neogenin, a receptor for bone morphogenetic proteins.
Volume: 286
Issue: 7
Pages: 5157-65
Publication
First Author: Zhang Q
Year: 2015
Journal: Oncol Rep
Title: Overexpression of neogenin inhibits cell proliferation and induces apoptosis in human MDA-MB-231 breast carcinoma cells.
Volume: 34
Issue: 1
Pages: 258-64
Publication
First Author: Rajagopalan S
Year: 2004
Journal: Nat Cell Biol
Title: Neogenin mediates the action of repulsive guidance molecule.
Volume: 6
Issue: 8
Pages: 756-62
Publication
First Author: Zhou Z
Year: 2010
Journal: Dev Cell
Title: Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation.
Volume: 19
Issue: 1
Pages: 90-102
Publication
First Author: Lee DH
Year: 2010
Journal: Blood
Title: Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis.
Volume: 115
Issue: 15
Pages: 3136-45
Publication
First Author: Wilson NH
Year: 2007
Journal: Int J Biochem Cell Biol
Title: Neogenin: one receptor, many functions.
Volume: 39
Issue: 5
Pages: 874-8
Publication
First Author: Wilson NH
Year: 2006
Journal: Dev Biol
Title: Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain.
Volume: 296
Issue: 2
Pages: 485-98
Publication
First Author: Matsunaga E
Year: 2004
Journal: Dev Growth Differ
Title: Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development.
Volume: 46
Issue: 6
Pages: 481-6
Publication
First Author: Kim SJ
Year: 2014
Journal: Oncotarget
Title: Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer.
Volume: 5
Issue: 10
Pages: 3386-98
Protein Domain
Type: Family
Description: Neogenin (NEO1) is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily []. It displays identical secondary structure to DCC (deleted in colorectal cancer), a netrin receptor that is involved in axon guidance and cell survival. Similar to DCC, it is able to transduce signals elicited by netrin []. Netrin-Neogenin interactions result in a chemoattractive axon guidance response []. Neogenin is also a receptor for members of the repulsive guidance molecule (RGM) family, which act as a repulsive axon guidance cue [, , ]. RGM binding to NEO1 activates the bone morphogenetic protein (BMP)-regulated signalling involved in morphogenesis and iron homeostasis [, ].Neogenin has an important role in cancer development [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1055  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 1999
Title: Mouse Genome Informatics Orthology Assignments
Publication
First Author: Fuerst PG
Year: 2008
Journal: Nature
Title: Neurite arborization and mosaic spacing in the mouse retina require DSCAM.
Volume: 451
Issue: 7177
Pages: 470-4
Publication
First Author: Liu G
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: DSCAM functions as a netrin receptor in commissural axon pathfinding.
Volume: 106
Issue: 8
Pages: 2951-6
Publication
First Author: Yamagata M
Year: 2008
Journal: Nature
Title: Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina.
Volume: 451
Issue: 7177
Pages: 465-9
Publication
First Author: Schmucker D
Year: 2009
Journal: Genes Dev
Title: Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes.
Volume: 23
Issue: 2
Pages: 147-56
Publication
First Author: Lah GJ
Year: 2014
Journal: Neuron
Title: Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring.
Volume: 83
Issue: 6
Pages: 1376-88
Protein Domain
Type: Family
Description: Cell adhesion molecule DSCAM is a cell adhesion molecule that plays a role in axon guidance, self-avoidance and synaptic formation [, , , , ]. It is a receptor for netrin, acting independently of and in collaboration with DCC []. DSCAM is one of the largest Immunoglobulin (Ig) superfamily CAMs, containing 10 Ig domains and six fibronectin type III (FN) repeats [], and contributes to defects in the central nervous system in Down syndrome patients []. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene []. Drosophila Dscam2 is also alternatively spliced and plays a crucial role in the development of two visual system neurons, monopolar cells L1 and L2 [].
Publication
First Author: Meli R
Year: 2015
Journal: PLoS One
Title: Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and microtubule-associated protein 1B.
Volume: 10
Issue: 3
Pages: e0119524
Publication
First Author: van den Broek FA
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Genetic analysis of dystrophic cardiac calcification in DBA/2 mice.
Volume: 253
Issue: 2
Pages: 204-8
HT Experiment
Series Id: GSE19871
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Publication
First Author: Meng H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics.
Volume: 104
Issue: 11
Pages: 4530-5
Publication
First Author: Park TJ
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Inhibition of ubiquitin ligase Siah-1A by disabled-1.
Volume: 302
Issue: 4
Pages: 671-8
Publication
First Author: Dillon AK
Year: 2007
Journal: Mol Cell Neurosci
Title: UNC5C is required for spinal accessory motor neuron development.
Volume: 35
Issue: 3
Pages: 482-9
Publication
First Author: Guijarro P
Year: 2006
Journal: Mol Cell Neurosci
Title: Netrin1 exerts a chemorepulsive effect on migrating cerebellar interneurons in a Dcc-independent way.
Volume: 33
Issue: 4
Pages: 389-400
Publication
First Author: Ivandic BT
Year: 2001
Journal: Physiol Genomics
Title: New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice.
Volume: 6
Issue: 3
Pages: 137-44
Publication
First Author: Schlienger S
Year: 2023
Journal: Sci Adv
Title: Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control.
Volume: 9
Issue: 19
Pages: eadd5501
Publication
First Author: Tawarayama H
Year: 2018
Journal: Sci Rep
Title: Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.
Volume: 8
Issue: 1
Pages: 840
Publication
First Author: Wong EW
Year: 2019
Journal: Learn Mem
Title: Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain.
Volume: 26
Issue: 3
Pages: 77-83
Publication
First Author: Jiang TX
Year: 1999
Journal: J Invest Dermatol
Title: Epidermal dysplasia and abnormal hair follicles in transgenic mice overexpressing homeobox gene MSX-2.
Volume: 113
Issue: 2
Pages: 230-7
Publication
First Author: Schneiders FI
Year: 2007
Journal: J Biol Chem
Title: Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
Volume: 282
Issue: 33
Pages: 23750-8
Publication
First Author: Brunnert SR
Year: 1990
Journal: Lab Anim Sci
Title: Dystrophic cardiac calcinosis in mice: abnormal myocardial response to freeze-thaw injury.
Volume: 40
Issue: 6
Pages: 616-9
Publication
First Author: van den Broek FA
Year: 1998
Journal: Lab Anim
Title: Effect of dietary fat level on the calcium content of heart and kidney in DBA/2 and C57BL/6 mice.
Volume: 32
Issue: 2
Pages: 206-13
Publication  
First Author: Ozmadenci D
Year: 2015
Journal: Nat Commun
Title: Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.
Volume: 6
Pages: 7398
Publication  
First Author: Reuten R
Year: 2016
Journal: Nat Commun
Title: Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
Volume: 7
Pages: 13515
Publication
First Author: Xiang C
Year: 2021
Journal: Mol Cell Biol
Title: RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons.
Volume: 41
Issue: 7
Pages: e0052620
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Publication
First Author: Hirano Y
Year: 2011
Journal: EMBO J
Title: Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain.
Volume: 30
Issue: 13
Pages: 2734-47
Publication
First Author: Petersen KJ
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: MyTH4-FERM myosins have an ancient and conserved role in filopod formation.
Volume: 113
Issue: 50
Pages: E8059-E8068
Protein Domain
Type: Domain
Description: MyoX, a MyTH-FERM myosin, is a molecular motor that has crucial functions in the transport and/or tethering of integrins in the actin-based extensions known as filopodia, microtubule binding, and in netrin-mediated axon guidance []. It functions as a dimer. MyoX walks on bundles of actin, rather than single filaments, unlike the other unconventional myosins. MyoX is present in organisms ranging from humans to choanoflagellates, but not in Drosophila and Caenorhabditis elegans.MyoX consists of a N-terminal motor/head region, a neck made of 3 IQ motifs, and a tail consisting of a coiled-coil domain, a PEST region, 3 PH domains, a myosin tail homology 4 (MyTH4), and a FERM domain at its very C terminus. The MyoX FERM domain binds to the NPXY motif of several beta-integrins, a key family of cell surface receptors that are involved in cell adhesion and migration. In addition to beta-integrins, the FERM domain binds to the cytoplasmic domains of the netrin receptors DCC (deleted in colorectal cancer) and neogenin []. The FERM domain also forms a supramodule with its MyTH4 domain which binds to the negatively charged E-hook region in the tails of alpha- and beta-tubulin forming a proposed motorized link between actin filaments and microtubules [, ].The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3) []. This entry represents the C-lobe of the MyoX FERM domain.
Publication
First Author: Lickert H
Year: 2005
Journal: Development
Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
Volume: 132
Issue: 11
Pages: 2599-609
Publication
First Author: Kerber ML
Year: 2011
Journal: J Cell Sci
Title: Myosin-X: a MyTH-FERM myosin at the tips of filopodia.
Volume: 124
Issue: Pt 22
Pages: 3733-41
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 535  
Fragment?: false
Publication
First Author: Fowles LF
Year: 2003
Journal: Genesis
Title: Genomic screen for genes involved in mammalian craniofacial development.
Volume: 35
Issue: 2
Pages: 73-87
Publication
First Author: Comerford SA
Year: 2023
Journal: PLoS Genet
Title: Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent.
Volume: 19
Issue: 1
Pages: e1010595
Publication
First Author: Wang H
Year: 1999
Journal: J Neurosci
Title: Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.
Volume: 19
Issue: 12
Pages: 4938-47
Publication
First Author: PuschelPüschel AW
Year: 1999
Journal: Mech Dev
Title: Divergent properties of mouse netrins.
Volume: 83
Issue: 1-2
Pages: 65-75
Publication
First Author: Dharmat R
Year: 2018
Journal: J Cell Biol
Title: SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.
Volume: 217
Issue: 8
Pages: 2851-2865
Publication
First Author: Leonardo ED
Year: 1997
Journal: Nature
Title: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.
Volume: 386
Issue: 6627
Pages: 833-8
Publication
First Author: Mazelin L
Year: 2004
Journal: Nature
Title: Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
Volume: 431
Issue: 7004
Pages: 80-4
Publication
First Author: Saba R
Year: 2003
Journal: J Neurosci
Title: Mammalian BarH1 confers commissural neuron identity on dorsal cells in the spinal cord.
Volume: 23
Issue: 6
Pages: 1987-91
Publication
First Author: Bachg AC
Year: 2019
Journal: Sci Rep
Title: Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X.
Volume: 9
Issue: 1
Pages: 597
Publication
First Author: Huang Z
Year: 2016
Journal: J Neurosci
Title: Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex.
Volume: 36
Issue: 21
Pages: 5833-49
Publication
First Author: Liakath-Ali K
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus.
Volume: 119
Issue: 20
Pages: e2123421119
Publication
First Author: Festing MF
Year: 1998
Journal: Genomics
Title: At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice.
Volume: 53
Issue: 2
Pages: 129-36
Publication
First Author: Sowa AK
Year: 2013
Journal: Am J Pathol
Title: Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification.
Volume: 183
Issue: 1
Pages: 60-8
Publication
First Author: Brunnert SR
Year: 1999
Journal: Genomics
Title: Chromosomal localization of the loci responsible for dystrophic cardiac calcinosis in DBA/2 mice.
Volume: 59
Issue: 1
Pages: 105-7
Publication
First Author: Aherrahrou Z
Year: 2008
Journal: J Biol Chem
Title: An alternative splice variant in Abcc6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice.
Volume: 283
Issue: 12
Pages: 7608-15
Publication
First Author: Luongo C
Year: 1996
Journal: Genes Chromosomes Cancer
Title: Somatic genetic events linked to the Apc locus in intestinal adenomas of the Min mouse.
Volume: 17
Issue: 3
Pages: 194-8
Publication
First Author: Haddick PC
Year: 2014
Journal: PLoS One
Title: Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor.
Volume: 9
Issue: 1
Pages: e84823
Publication
First Author: Aherrahrou Z
Year: 2004
Journal: Am J Pathol
Title: A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice.
Volume: 164
Issue: 4
Pages: 1379-87
Publication
First Author: Kubota C
Year: 2004
Journal: J Neurochem
Title: Netrin-1 is crucial for the establishment of the dorsal column-medial lemniscal system.
Volume: 89
Issue: 6
Pages: 1547-54
Publication
First Author: Hayes BB
Year: 1998
Journal: Drug Chem Toxicol
Title: Contact hypersensitivity to dicyclohexylcarbodiimide and diisopropylcarbodiimide in female B6C3F1 mice.
Volume: 21
Issue: 2
Pages: 195-206
Publication
First Author: Davis LM
Year: 1994
Journal: Carcinogenesis
Title: Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse.
Volume: 15
Issue: 8
Pages: 1637-45
Publication
First Author: van den Broek FA
Year: 1997
Journal: Lab Anim
Title: Co-variance of chemically and histologically analysed severity of dystrophic cardiac calcification in mice.
Volume: 31
Issue: 1
Pages: 74-80
Publication
First Author: Meyerhardt JA
Year: 1999
Journal: Cell Growth Differ
Title: Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.
Volume: 10
Issue: 1
Pages: 35-42
Publication
First Author: Fitzgerald DP
Year: 2006
Journal: Neuroscience
Title: Characterization of neogenin-expressing neural progenitor populations and migrating neuroblasts in the embryonic mouse forebrain.
Volume: 142
Issue: 3
Pages: 703-16
Publication
First Author: Aherrahrou Z
Year: 2007
Journal: Physiol Genomics
Title: Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification.
Volume: 28
Issue: 2
Pages: 203-12
Publication
First Author: Paradisi A
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression.
Volume: 106
Issue: 40
Pages: 17146-51
Publication
First Author: Rybak IA
Year: 2013
Journal: J Physiol
Title: Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion.
Volume: 591
Issue: 22
Pages: 5491-508
Publication
First Author: Li Q
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO.
Volume: 112
Issue: 3
Pages: 899-904
Publication
First Author: Tian C
Year: 2013
Journal: Mol Reprod Dev
Title: Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.
Volume: 80
Issue: 9
Pages: 700-17
Publication
First Author: Shao Q
Year: 2017
Journal: J Neurosci
Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.
Volume: 37
Issue: 23
Pages: 5620-5633
Publication
First Author: Sun XD
Year: 2018
Journal: J Neurosci
Title: Neogenin in Amygdala for Neuronal Activity and Information Processing.
Volume: 38
Issue: 44
Pages: 9600-9613
Publication
First Author: Merriman TR
Year: 2001
Journal: Diabetes
Title: Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.
Volume: 50
Issue: 1
Pages: 184-94
Publication
First Author: Zhang AS
Year: 2005
Journal: J Biol Chem
Title: Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells.
Volume: 280
Issue: 40
Pages: 33885-94
Publication
First Author: Li Q
Year: 2016
Journal: Mamm Genome
Title: Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.
Volume: 27
Issue: 5-6
Pages: 179-90
Publication
First Author: Fuerst PG
Year: 2009
Journal: Neuron
Title: DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
Volume: 64
Issue: 4
Pages: 484-97
Publication
First Author: Yamakawa K
Year: 1998
Journal: Hum Mol Genet
Title: DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system.
Volume: 7
Issue: 2
Pages: 227-37
Publication
First Author: Zhu K
Year: 2011
Journal: Neurosci Bull
Title: Down syndrome cell adhesion molecule and its functions in neural development.
Volume: 27
Issue: 1
Pages: 45-52
Protein
Organism: Mus musculus/domesticus
Length: 1493  
Fragment?: false