| Type |
Details |
Score |
| Publication |
| First Author: |
Sullivan JA |
| Year: |
2007 |
| Journal: |
Mol Biol Cell |
| Title: |
Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. |
| Volume: |
18 |
| Issue: |
7 |
| Pages: |
2429-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu XF |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. |
| Volume: |
272 |
| Issue: |
18 |
| Pages: |
11763-9 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [, ]. Ndfip1 plays a role in regulating metal transport in human neurons []. Bsd2 is required for the targeting of several proteins into the MVB (multivesicular body) pathway []. It prevents metal hyperaccumulation by exerting negative control over the Smf1 and Smf2 metal transport systems []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koshizuka T |
| Year: |
2016 |
| Journal: |
J Gen Virol |
| Title: |
Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42. |
| Volume: |
97 |
| Issue: |
1 |
| Pages: |
196-208 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Members of this family include UL42 proteins found in Human cytomegalovirus (HCMV). UL42 has two Pro-Pro-X-Tyr (PPxY) sequences, a hydrophobic region at the C terminus and no N-terminal signal peptide. These features are shared with herpes simplex virus (HSV) UL56. UL42 has a putative C-terminal trans-membrane region. HCMV UL42 interacts with Itch, a member of the Nedd4 family of ubiquitin E3 ligases, through its PY motifs as observed in HSV UL56, suggestive of a regulatory function []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ouchida R |
| Year: |
2010 |
| Journal: |
J Immunol |
| Title: |
A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation. |
| Volume: |
185 |
| Issue: |
1 |
| Pages: |
294-301 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ouchida R |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation. |
| Volume: |
29 |
| Issue: |
1 |
| Pages: |
33-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pak Y |
| Year: |
2006 |
| Journal: |
J Cell Biol |
| Title: |
Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. |
| Volume: |
175 |
| Issue: |
4 |
| Pages: |
631-45 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.This entry represents LAPTM5, which is a lysosomal protein expressed in cells of lymphoid and myeloid origin. LAPTM5 trafficking from the Golgi to the lysosome requires its association with the ubiquitin ligase Nedd4 and the clathrin adaptor GGA3 []. LAPTM5 negatively regulates T and B cell receptor signaling by directly interacting with these receptors and mediating their down-regulation [, ]. It is also a positive regulator of NF-kB and MAPK signaling allowing efficient proinflammatory cytokine production in response to macrophage activation []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nassar MA |
| Year: |
2004 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. |
| Volume: |
101 |
| Issue: |
34 |
| Pages: |
12706-11 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
86
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
107
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kota J |
| Year: |
2007 |
| Journal: |
Genetics |
| Title: |
Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae. |
| Volume: |
175 |
| Issue: |
4 |
| Pages: |
1681-94 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cox JJ |
| Year: |
2006 |
| Journal: |
Nature |
| Title: |
An SCN9A channelopathy causes congenital inability to experience pain. |
| Volume: |
444 |
| Issue: |
7121 |
| Pages: |
894-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cox JJ |
| Year: |
2010 |
| Journal: |
Hum Mutat |
| Title: |
Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations. |
| Volume: |
31 |
| Issue: |
9 |
| Pages: |
E1670-86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Léon S |
| Year: |
2008 |
| Journal: |
Mol Biol Cell |
| Title: |
Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies. |
| Volume: |
19 |
| Issue: |
6 |
| Pages: |
2379-88 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [, , ]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents the SPRY domain found in Ssh4 (suppressor of SHR3 null mutation protein 4) and similar proteins. Ssh4 is a component of the endosome-vacuole trafficking pathway that regulates nutrient transport and may be involved in processes determining whether plasma membrane proteins are degraded or routed to the plasma membrane []. The SPRY domain in Ssh4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. In yeast, Ssh4 and the homologous protein Ear1 (endosomal adapter of RSP5) recruit Rsp5p, an essential ubiquitin ligase of the Nedd4 family, and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
González-Calvo I |
| Year: |
2021 |
| Journal: |
Elife |
| Title: |
Sushi domain-containing protein 4 controls synaptic plasticity and motor learning. |
| Volume: |
10 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Guo Q |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation. |
| Volume: |
42 |
| Issue: |
9 |
| Pages: |
113070 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Han SO |
| Year: |
2012 |
| Journal: |
J Cell Biol |
| Title: |
MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. |
| Volume: |
199 |
| Issue: |
5 |
| Pages: |
817-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Alix E |
| Year: |
2020 |
| Journal: |
Cell Host Microbe |
| Title: |
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. |
| Volume: |
28 |
| Issue: |
1 |
| Pages: |
54-68.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lopez RG |
| Year: |
2009 |
| Journal: |
Nat Cell Biol |
| Title: |
C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. |
| Volume: |
11 |
| Issue: |
10 |
| Pages: |
1181-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McLachlan S |
| Year: |
2011 |
| Journal: |
Physiol Genomics |
| Title: |
In silico QTL mapping of basal liver iron levels in inbred mouse strains. |
| Volume: |
43 |
| Issue: |
3 |
| Pages: |
136-47 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
267
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
263
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
231
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
173
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
241
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
264
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
261
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen XL |
| Year: |
2014 |
| Journal: |
Mol Cell Biol |
| Title: |
Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. |
| Volume: |
34 |
| Issue: |
20 |
| Pages: |
3855-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gasser A |
| Year: |
2010 |
| Journal: |
J Biol Chem |
| Title: |
Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. |
| Volume: |
285 |
| Issue: |
34 |
| Pages: |
26149-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyauchi S |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18. |
| Volume: |
42 |
| Issue: |
12 |
| Pages: |
113560 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Henshall TL |
| Year: |
2017 |
| Journal: |
Cell Death Differ |
| Title: |
Deletion of Nedd4-2 results in progressive kidney disease in mice. |
| Volume: |
24 |
| Issue: |
12 |
| Pages: |
2150-2160 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang X |
| Year: |
2022 |
| Journal: |
Theranostics |
| Title: |
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
2613-2630 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim E |
| Year: |
2016 |
| Journal: |
Hum Mol Genet |
| Title: |
NEDD4-mediated HSF1 degradation underlies α-synucleinopathy. |
| Volume: |
25 |
| Issue: |
2 |
| Pages: |
211-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim T |
| Year: |
2021 |
| Journal: |
J Cereb Blood Flow Metab |
| Title: |
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage. |
| Volume: |
41 |
| Issue: |
5 |
| Pages: |
1058-1066 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bulek K |
| Year: |
2020 |
| Journal: |
J Clin Invest |
| Title: |
Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. |
| Volume: |
130 |
| Issue: |
8 |
| Pages: |
4218-4234 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu W |
| Year: |
2017 |
| Journal: |
J Biol Chem |
| Title: |
The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. |
| Volume: |
292 |
| Issue: |
27 |
| Pages: |
11178-11188 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yin Q |
| Year: |
2020 |
| Journal: |
Semin Cancer Biol |
| Title: |
ITCH as a potential therapeutic target in human cancers. |
| Volume: |
67 |
| Issue: |
Pt 2 |
| Pages: |
117-130 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chapalamadugu KC |
| Year: |
2018 |
| Journal: |
Acta Physiol (Oxf) |
| Title: |
Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation. |
| Volume: |
224 |
| Issue: |
2 |
| Pages: |
e13083 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sakurai Y |
| Year: |
2024 |
| Journal: |
Diabetes |
| Title: |
Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass. |
| Volume: |
73 |
| Issue: |
3 |
| Pages: |
474-489 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Catterall WA |
| Year: |
2000 |
| Journal: |
Neuron |
| Title: |
From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
13-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Catterall WA |
| Year: |
2005 |
| Journal: |
Pharmacol Rev |
| Title: |
International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. |
| Volume: |
57 |
| Issue: |
4 |
| Pages: |
397-409 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2004 |
| Journal: |
Oncogene |
| Title: |
An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. |
| Volume: |
23 |
| Issue: |
10 |
| Pages: |
1801-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jacque E |
| Year: |
2009 |
| Journal: |
EMBO J |
| Title: |
RNF11, a new piece in the A20 puzzle. |
| Volume: |
28 |
| Issue: |
5 |
| Pages: |
455-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kostaras E |
| Year: |
2013 |
| Journal: |
Oncogene |
| Title: |
SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. |
| Volume: |
32 |
| Issue: |
44 |
| Pages: |
5220-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Santonico E |
| Year: |
2015 |
| Journal: |
Oncogene |
| Title: |
RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch. |
| Volume: |
34 |
| Issue: |
26 |
| Pages: |
3377-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shembade N |
| Year: |
2011 |
| Journal: |
Nat Immunol |
| Title: |
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. |
| Volume: |
12 |
| Issue: |
9 |
| Pages: |
834-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kitching R |
| Year: |
2003 |
| Journal: |
Biochim Biophys Acta |
| Title: |
The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. |
| Volume: |
1639 |
| Issue: |
2 |
| Pages: |
104-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Subramaniam V |
| Year: |
2003 |
| Journal: |
Br J Cancer |
| Title: |
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. |
| Volume: |
89 |
| Issue: |
8 |
| Pages: |
1538-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Azmi PB |
| Year: |
2009 |
| Journal: |
Anticancer Res |
| Title: |
The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
2253-63 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
RING finger protein 11 (RNF11) is an E3 ubiquitin-protein ligase that acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic. It is the downstream of an enzymatic cascade for the ubiquitination of specific substrates. It is also a molecular adaptor of homologous to E6-associated protein C terminus (HECT)-type ligases []. RNF11 has been implicated in the regulation of several signaling pathways. It enhances the transforming growth factor receptor (TGFR) signaling by both abrogating Smurf2-mediated receptor ubiquitination and by promoting the Smurf2-mediated degradation of AMSH (associated molecule with the SH3 domain of STAM), a de-ubiquitinating enzyme that enhances transforming growth factor-beta (TGF-beta) signalling and epidermal growth factor receptor (EGFR) endosomal recycling [, ]. It also acts directly on Smad4 to enhance Smad4 function, and plays a role in prolonged TGF-beta signalling []. Moreover, RNF11 functions as a critical component of the A20 ubiquitin-editing protein complex that negatively regulates tumor necrosis factor (TNF)-mediated nuclear factor (NF)-kappaB activation []. It also interacts with Smad anchor for receptor activation (SARA) and the endosomal sorting complex required for transport (ESCRT)-0 complex, thus participating in the regulation of lysosomal degradation of EGFR []. Furthermore, RNF11 acts as a novel GGA cargo actively participating in regulating the ubiquitination of the GGA protein family []. In addition, RNF11 functions together with TAX1BP1 to target TANK-binding kinase 1 (TBK1)/IkappaB kinase IKKi, and further restricts antiviral signaling and type I interferon (IFN)-beta production []. RNF11 contains an N-terminal PPPY motif that binds WW domain-containing proteins such as AIP4/itch, Nedd4 and Smurf1/2 (SMAD-specific E3 ubiquitin-protein ligase 1/2), and a C-terminal C3H2C3-type RING-H2 finger that functions as a scaffold for the coordinated transfer of ubiquitin to substrate proteins together with the E2 enzymes UbcH527 and Ubc13. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang YJ |
| Year: |
2023 |
| Journal: |
FASEB J |
| Title: |
Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD. |
| Volume: |
37 |
| Issue: |
7 |
| Pages: |
e23008 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chandrasekaran K |
| Year: |
2019 |
| Journal: |
Brain |
| Title: |
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy. |
| Volume: |
142 |
| Issue: |
12 |
| Pages: |
3737-3752 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
118
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li H |
| Year: |
2006 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. |
| Volume: |
33 |
| Issue: |
2 |
| Pages: |
136-49 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Easterday MC |
| Year: |
2003 |
| Journal: |
Dev Biol |
| Title: |
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. |
| Volume: |
264 |
| Issue: |
2 |
| Pages: |
309-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McClive PJ |
| Year: |
2003 |
| Journal: |
Genesis |
| Title: |
Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. |
| Volume: |
37 |
| Issue: |
2 |
| Pages: |
84-90 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
478
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1984
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1984
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1973
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1932
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1973
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1975
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1973
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
144
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1973
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health |
| Year: |
2001 |
|
| Title: |
GenBank Record Derived Information |
|
|
|
|
•
•
•
•
•
|