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Search results 1701 to 1800 out of 1836 for Nedd4

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Type Details Score
Publication
First Author: Sullivan JA
Year: 2007
Journal: Mol Biol Cell
Title: Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro.
Volume: 18
Issue: 7
Pages: 2429-40
Publication
First Author: Liu XF
Year: 1997
Journal: J Biol Chem
Title: Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene.
Volume: 272
Issue: 18
Pages: 11763-9
Protein Domain
Type: Family
Description: Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [, ]. Ndfip1 plays a role in regulating metal transport in human neurons []. Bsd2 is required for the targeting of several proteins into the MVB (multivesicular body) pathway []. It prevents metal hyperaccumulation by exerting negative control over the Smf1 and Smf2 metal transport systems [].
Publication
First Author: Koshizuka T
Year: 2016
Journal: J Gen Virol
Title: Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42.
Volume: 97
Issue: 1
Pages: 196-208
Protein Domain
Type: Family
Description: Members of this family include UL42 proteins found in Human cytomegalovirus (HCMV). UL42 has two Pro-Pro-X-Tyr (PPxY) sequences, a hydrophobic region at the C terminus and no N-terminal signal peptide. These features are shared with herpes simplex virus (HSV) UL56. UL42 has a putative C-terminal trans-membrane region. HCMV UL42 interacts with Itch, a member of the Nedd4 family of ubiquitin E3 ligases, through its PY motifs as observed in HSV UL56, suggestive of a regulatory function [].
Publication
First Author: Ouchida R
Year: 2010
Journal: J Immunol
Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Volume: 185
Issue: 1
Pages: 294-301
Publication
First Author: Ouchida R
Year: 2008
Journal: Immunity
Title: A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Volume: 29
Issue: 1
Pages: 33-43
Publication
First Author: Pak Y
Year: 2006
Journal: J Cell Biol
Title: Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination.
Volume: 175
Issue: 4
Pages: 631-45
Protein Domain
Type: Family
Description: The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.This entry represents LAPTM5, which is a lysosomal protein expressed in cells of lymphoid and myeloid origin. LAPTM5 trafficking from the Golgi to the lysosome requires its association with the ubiquitin ligase Nedd4 and the clathrin adaptor GGA3 []. LAPTM5 negatively regulates T and B cell receptor signaling by directly interacting with these receptors and mediating their down-regulation [, ]. It is also a positive regulator of NF-kB and MAPK signaling allowing efficient proinflammatory cytokine production in response to macrophage activation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Nassar MA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.
Volume: 101
Issue: 34
Pages: 12706-11
Protein
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
Publication
First Author: Kota J
Year: 2007
Journal: Genetics
Title: Ssh4, Rcr2 and Rcr1 affect plasma membrane transporter activity in Saccharomyces cerevisiae.
Volume: 175
Issue: 4
Pages: 1681-94
Publication
First Author: Cox JJ
Year: 2006
Journal: Nature
Title: An SCN9A channelopathy causes congenital inability to experience pain.
Volume: 444
Issue: 7121
Pages: 894-8
Publication
First Author: Cox JJ
Year: 2010
Journal: Hum Mutat
Title: Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations.
Volume: 31
Issue: 9
Pages: E1670-86
Publication
First Author: Léon S
Year: 2008
Journal: Mol Biol Cell
Title: Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.
Volume: 19
Issue: 6
Pages: 2379-88
Protein Domain
Type: Family
Description: Nine voltage-gated sodium channels (Navs) are expressed in complex patterns in mammalian nerve and muscle. These channels mediate the influx of Na+ ions in response to local depolarising stimuli. Nav channels are composed of a pore-forming alpha-subunit associated with one or more auxiliary beta-subunits. The pore-forming alpha subunit is sufficient for functional expression, but the localisation, kinetics and voltage dependence of channel gating are modified by the beta subunits [, ].Sodium channel protein type 9 subunit alpha (also known as Nav1.7 or SCN9A) is strongly expressed in nociceptive neurons and plays a role in pain mechanisms, especially in the development of inflammatory pain [, , ]. It interacts with the ubiquitin-protein ligases Nedd4 and Nedd4-2, known to regulate receptors and ion transporters [].
Protein Domain
Type: Domain
Description: This entry represents the SPRY domain found in Ssh4 (suppressor of SHR3 null mutation protein 4) and similar proteins. Ssh4 is a component of the endosome-vacuole trafficking pathway that regulates nutrient transport and may be involved in processes determining whether plasma membrane proteins are degraded or routed to the plasma membrane []. The SPRY domain in Ssh4 may be involved in cargo recognition, either directly or by combination with other adaptors, possibly leading to a higher selectivity. In yeast, Ssh4 and the homologous protein Ear1 (endosomal adapter of RSP5) recruit Rsp5p, an essential ubiquitin ligase of the Nedd4 family, and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes [].
Publication    
First Author: González-Calvo I
Year: 2021
Journal: Elife
Title: Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.
Volume: 10
Publication
First Author: Guo Q
Year: 2023
Journal: Cell Rep
Title: TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation.
Volume: 42
Issue: 9
Pages: 113070
Publication
First Author: Han SO
Year: 2012
Journal: J Cell Biol
Title: MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.
Volume: 199
Issue: 5
Pages: 817-30
Publication
First Author: Alix E
Year: 2020
Journal: Cell Host Microbe
Title: The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Volume: 28
Issue: 1
Pages: 54-68.e7
Publication
First Author: Lopez RG
Year: 2009
Journal: Nat Cell Biol
Title: C/EBPalpha and beta couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation.
Volume: 11
Issue: 10
Pages: 1181-90
Publication
First Author: McLachlan S
Year: 2011
Journal: Physiol Genomics
Title: In silico QTL mapping of basal liver iron levels in inbred mouse strains.
Volume: 43
Issue: 3
Pages: 136-47
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
Publication
First Author: Chen XL
Year: 2014
Journal: Mol Cell Biol
Title: Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.
Volume: 34
Issue: 20
Pages: 3855-66
Publication
First Author: Gasser A
Year: 2010
Journal: J Biol Chem
Title: Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
Volume: 285
Issue: 34
Pages: 26149-61
Publication
First Author: Miyauchi S
Year: 2023
Journal: Cell Rep
Title: Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18.
Volume: 42
Issue: 12
Pages: 113560
Publication
First Author: Henshall TL
Year: 2017
Journal: Cell Death Differ
Title: Deletion of Nedd4-2 results in progressive kidney disease in mice.
Volume: 24
Issue: 12
Pages: 2150-2160
Publication
First Author: Wang X
Year: 2022
Journal: Theranostics
Title: PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
Volume: 12
Issue: 6
Pages: 2613-2630
Publication
First Author: Kim E
Year: 2016
Journal: Hum Mol Genet
Title: NEDD4-mediated HSF1 degradation underlies α-synucleinopathy.
Volume: 25
Issue: 2
Pages: 211-22
Publication
First Author: Kim T
Year: 2021
Journal: J Cereb Blood Flow Metab
Title: Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Volume: 41
Issue: 5
Pages: 1058-1066
Publication
First Author: Bulek K
Year: 2020
Journal: J Clin Invest
Title: Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis.
Volume: 130
Issue: 8
Pages: 4218-4234
Publication
First Author: Zhu W
Year: 2017
Journal: J Biol Chem
Title: The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation.
Volume: 292
Issue: 27
Pages: 11178-11188
Publication
First Author: Yin Q
Year: 2020
Journal: Semin Cancer Biol
Title: ITCH as a potential therapeutic target in human cancers.
Volume: 67
Issue: Pt 2
Pages: 117-130
Publication
First Author: Chapalamadugu KC
Year: 2018
Journal: Acta Physiol (Oxf)
Title: Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation.
Volume: 224
Issue: 2
Pages: e13083
Publication
First Author: Sakurai Y
Year: 2024
Journal: Diabetes
Title: Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass.
Volume: 73
Issue: 3
Pages: 474-489
Publication
First Author: Catterall WA
Year: 2000
Journal: Neuron
Title: From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
Volume: 26
Issue: 1
Pages: 13-25
Publication
First Author: Catterall WA
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
Volume: 57
Issue: 4
Pages: 397-409
Publication
First Author: Li H
Year: 2004
Journal: Oncogene
Title: An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.
Volume: 23
Issue: 10
Pages: 1801-8
Publication
First Author: Jacque E
Year: 2009
Journal: EMBO J
Title: RNF11, a new piece in the A20 puzzle.
Volume: 28
Issue: 5
Pages: 455-6
Publication
First Author: Kostaras E
Year: 2013
Journal: Oncogene
Title: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.
Volume: 32
Issue: 44
Pages: 5220-32
Publication
First Author: Santonico E
Year: 2015
Journal: Oncogene
Title: RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch.
Volume: 34
Issue: 26
Pages: 3377-90
Publication
First Author: Shembade N
Year: 2011
Journal: Nat Immunol
Title: The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Volume: 12
Issue: 9
Pages: 834-43
Publication
First Author: Kitching R
Year: 2003
Journal: Biochim Biophys Acta
Title: The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases.
Volume: 1639
Issue: 2
Pages: 104-12
Publication
First Author: Subramaniam V
Year: 2003
Journal: Br J Cancer
Title: The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
Volume: 89
Issue: 8
Pages: 1538-44
Publication
First Author: Azmi PB
Year: 2009
Journal: Anticancer Res
Title: The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling.
Volume: 29
Issue: 6
Pages: 2253-63
Protein Domain
Type: Domain
Description: RING finger protein 11 (RNF11) is an E3 ubiquitin-protein ligase that acts both as an adaptor and a modulator of itch-mediated control of ubiquitination events underlying membrane traffic. It is the downstream of an enzymatic cascade for the ubiquitination of specific substrates. It is also a molecular adaptor of homologous to E6-associated protein C terminus (HECT)-type ligases []. RNF11 has been implicated in the regulation of several signaling pathways. It enhances the transforming growth factor receptor (TGFR) signaling by both abrogating Smurf2-mediated receptor ubiquitination and by promoting the Smurf2-mediated degradation of AMSH (associated molecule with the SH3 domain of STAM), a de-ubiquitinating enzyme that enhances transforming growth factor-beta (TGF-beta) signalling and epidermal growth factor receptor (EGFR) endosomal recycling [, ]. It also acts directly on Smad4 to enhance Smad4 function, and plays a role in prolonged TGF-beta signalling []. Moreover, RNF11 functions as a critical component of the A20 ubiquitin-editing protein complex that negatively regulates tumor necrosis factor (TNF)-mediated nuclear factor (NF)-kappaB activation []. It also interacts with Smad anchor for receptor activation (SARA) and the endosomal sorting complex required for transport (ESCRT)-0 complex, thus participating in the regulation of lysosomal degradation of EGFR []. Furthermore, RNF11 acts as a novel GGA cargo actively participating in regulating the ubiquitination of the GGA protein family []. In addition, RNF11 functions together with TAX1BP1 to target TANK-binding kinase 1 (TBK1)/IkappaB kinase IKKi, and further restricts antiviral signaling and type I interferon (IFN)-beta production []. RNF11 contains an N-terminal PPPY motif that binds WW domain-containing proteins such as AIP4/itch, Nedd4 and Smurf1/2 (SMAD-specific E3 ubiquitin-protein ligase 1/2), and a C-terminal C3H2C3-type RING-H2 finger that functions as a scaffold for the coordinated transfer of ubiquitin to substrate proteins together with the E2 enzymes UbcH527 and Ubc13.
Publication
First Author: Zhang YJ
Year: 2023
Journal: FASEB J
Title: Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD.
Volume: 37
Issue: 7
Pages: e23008
Publication
First Author: Chandrasekaran K
Year: 2019
Journal: Brain
Title: Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Volume: 142
Issue: 12
Pages: 3737-3752
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Publication
First Author: Li H
Year: 2006
Journal: Mol Cell Neurosci
Title: Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.
Volume: 33
Issue: 2
Pages: 136-49
Publication
First Author: Easterday MC
Year: 2003
Journal: Dev Biol
Title: Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Volume: 264
Issue: 2
Pages: 309-22
Publication
First Author: McClive PJ
Year: 2003
Journal: Genesis
Title: Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad.
Volume: 37
Issue: 2
Pages: 84-90
Protein
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1984  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1984  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1932  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1975  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1973  
Fragment?: false
Publication        
First Author: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health
Year: 2001
Title: GenBank Record Derived Information