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Search results 201 to 300 out of 4320 for Apc

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Type Details Score
Publication
20976827 | J:294141
First Author: Cole AM
Year: 2010
Journal: EMBO Mol Med
Title: p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.
Volume: 2
Issue: 11
Pages: 472-86
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Publication
26411367 | J:234310
First Author: Kuo TL
Year: 2016
Journal: Oncogene
Title: APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice.
Volume: 35
Issue: 17
Pages: 2223-34
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Publication
20729907 | J:166564
First Author: Radulescu S
Year: 2010
Journal: Oncogene
Title: Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.
Volume: 29
Issue: 49
Pages: 6418-27
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Publication
19194513 | J:146495
First Author: Elahi E
Year: 2009
Journal: PLoS One
Title: Five quantitative trait loci control radiation-induced adenoma multiplicity in Mom1R Apc Min/+ mice.
Volume: 4
Issue: 2
Pages: e4388
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Publication
21498506 | -
First Author: Tanneberger K
Year: 2011
Journal: J Biol Chem
Title: Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1).
Volume: 286
Issue: 22
Pages: 19204-14
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Publication
29672847 | J:265573
First Author: Morris HT
Year: 2018
Journal: J Pathol
Title: Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Volume: 245
Issue: 3
Pages: 337-348
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Publication
22893683 | J:189809
First Author: Shaked H
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.
Volume: 109
Issue: 35
Pages: 14007-12
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Publication
11729120 | J:72879
First Author: Cooper HS
Year: 2001
Journal: Gastroenterology
Title: The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium-induced colitis.
Volume: 121
Issue: 6
Pages: 1407-16
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Publication
16959882 | J:113749
First Author: Sansom OJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Volume: 103
Issue: 38
Pages: 14122-7
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Publication
10602475 | J:59017
First Author: Kongkanuntn R
Year: 1999
Journal: Oncogene
Title: Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.
Volume: 18
Issue: 51
Pages: 7219-25
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Publication
26527747 | J:316572
First Author: Bae JA
Year: 2016
Journal: Clin Cancer Res
Title: Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss.
Volume: 22
Issue: 5
Pages: 1284-94
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Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
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Publication
30721564 | J:294462
First Author: Sartor C
Year: 2019
Journal: Liver Int
Title: The concomitant loss of APC and HNF4α in adult hepatocytes does not contribute to hepatocarcinogenesis driven by β-catenin activation.
Volume: 39
Issue: 4
Pages: 727-739
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Publication
15294912 | J:94014
First Author: Moran AE
Year: 2004
Journal: J Biol Chem
Title: Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.
Volume: 279
Issue: 41
Pages: 43261-72
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Publication
23998936 | J:211367
First Author: Hammoudi A
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).
Volume: 440
Issue: 3
Pages: 364-70
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Publication
24833705 | J:221729
First Author: Powell AE
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.
Volume: 307
Issue: 1
Pages: G16-23
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Publication
9307281 | J:42733
First Author: Fox JG
Year: 1997
Journal: Cancer Res
Title: Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection.
Volume: 57
Issue: 18
Pages: 3972-8
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Publication
12034317 | J:77184
First Author: Andreassen A
Year: 2002
Journal: Mutat Res
Title: One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene.
Volume: 517
Issue: 1-2
Pages: 157-66
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Publication
22303319 | J:309622
 
First Author: McKay JA
Year: 2011
Journal: Front Genet
Title: Effect of maternal and post-weaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice.
Volume: 2
Pages: 23
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Publication
23769888 | J:199069
First Author: Feng Y
Year: 2013
Journal: Am J Pathol
Title: Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation.
Volume: 183
Issue: 2
Pages: 493-503
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Publication
11691815 | J:73030
First Author: Kuraguchi M
Year: 2001
Journal: Cancer Res
Title: The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.
Volume: 61
Issue: 21
Pages: 7934-42
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Publication
21062985 | J:166853
First Author: Diegel CR
Year: 2010
Journal: Cancer Res
Title: Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.
Volume: 70
Issue: 22
Pages: 9143-52
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Publication
9054624 | J:39174
First Author: Smits R
Year: 1997
Journal: Carcinogenesis
Title: Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Volume: 18
Issue: 2
Pages: 321-7
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Publication
24890436 | J:217020
First Author: Rebel H
Year: 2015
Journal: Int J Cancer
Title: UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet.
Volume: 136
Issue: 2
Pages: 271-7
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Publication
15567712 | J:94056
First Author: Murata T
Year: 2004
Journal: Gene Expr Patterns
Title: ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype.
Volume: 5
Issue: 2
Pages: 171-8
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Author
Manavalan APC
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Lim APC
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Author
Takano APC
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Author
Wong APC
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GO Term
GO:0010997 | anaphase-promoting complex binding
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Publication
17989230 | J:127452
First Author: Shibata H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Alpha-catenin is essential in intestinal adenoma formation.
Volume: 104
Issue: 46
Pages: 18199-204
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Publication
35947664 | J:327420
First Author: Chun SK
Year: 2022
Journal: Sci Adv
Title: Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer.
Volume: 8
Issue: 32
Pages: eabo2389
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Publication
29163805 | J:256596
First Author: Xu J
Year: 2017
Journal: Oncotarget
Title: Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression.
Volume: 8
Issue: 52
Pages: 89988-89997
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Publication
31736871 | J:289568
 
First Author: Counts BR
Year: 2019
Journal: Front Endocrinol (Lausanne)
Title: The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female Apc Min/+ Mice.
Volume: 10
Pages: 720
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Publication
28351943 | J:317534
First Author: Tabrizian T
Year: 2017
Journal: Endocr Relat Cancer
Title: Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis.
Volume: 24
Issue: 6
Pages: 253-265
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Publication
26766442 | J:239972
First Author: Chiu CWN
Year: 2016
Journal: Dev Cell
Title: SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.
Volume: 36
Issue: 1
Pages: 50-62
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Publication
30622113 | J:273229
First Author: Flanagan DJ
Year: 2019
Journal: Cancer Res
Title: Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations.
Volume: 79
Issue: 5
Pages: 970-981
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Publication
7781071 | J:26137
First Author: MacPhee M
Year: 1995
Journal: Cell
Title: The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia.
Volume: 81
Issue: 6
Pages: 957-66
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Publication
8242739 | J:15703
First Author: Dietrich WF
Year: 1993
Journal: Cell
Title: Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse.
Volume: 75
Issue: 4
Pages: 631-9
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Publication
10716720 | J:61200
First Author: Halberg RB
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers.
Volume: 97
Issue: 7
Pages: 3461-6
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Publication
9684289 | J:52642
First Author: Dove WF
Year: 1998
Journal: Philos Trans R Soc Lond B Biol Sci
Title: The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.
Volume: 353
Issue: 1370
Pages: 915-23
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Protein Coding Gene
MGI:2388100 | Sapcd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22128170 | -
First Author: Pfister AS
Year: 2012
Journal: J Biol Chem
Title: Amer2 protein is a novel negative regulator of Wnt/β-catenin signaling involved in neuroectodermal patterning.
Volume: 287
Issue: 3
Pages: 1734-41
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Publication
20843316 | -
 
First Author: Boutet A
Year: 2010
Journal: BMC Evol Biol
Title: The WTX/AMER1 gene family: evolution, signature and function.
Volume: 10
Pages: 280
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Protein Domain
IPR019003 | AMER
Type: Family
Description: This entry includes APC membrane recruitment protein 1/2/3 (Amer1/2/3). Amer1, also known as WTX, binds to the tumour suppressor adenomatous polyposis coli and acts as an inhibitor of Wnt signaling by inducing beta-catenin degradation []. Amer2 is a negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning [].WTX is a novel gene mutated in a proportion of Wilms' tumors and in patients suffering from sclerosing bone dysplasia [].
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Gene
689616 | Apcdd1
Type: gene
Organism: rat
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Gene
480209 | APCDD1
Type: gene
Organism: dog, domestic
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Gene
455287 | APCDD1
Type: gene
Organism: chimpanzee
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Gene
499949 | Apcdd1l
Type: gene
Organism: rat
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Gene
735545 | APCDD1L
Type: gene
Organism: chimpanzee
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Gene
611907 | APCDD1L
Type: gene
Organism: dog, domestic
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Gene
509040 | APCDD1
Type: gene
Organism: cattle
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Gene
617376 | APCDD1L
Type: gene
Organism: cattle
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Gene
419316 | APCDD1L
Type: gene
Organism: chicken
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Gene
426765 | APCDD1
Type: gene
Organism: chicken
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Gene
699020 | APCDD1L
Type: gene
Organism: macaque, rhesus
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Gene
114673868 | APCDD1
Type: gene
Organism: macaque, rhesus
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Publication
30374053 | J:268691
First Author: Jung YS
Year: 2018
Journal: Nat Cell Biol
Title: TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling.
Volume: 20
Issue: 12
Pages: 1421-1433
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Publication
12730693 | J:83087
First Author: Sansom OJ
Year: 2003
Journal: Nat Genet
Title: Deficiency of Mbd2 suppresses intestinal tumorigenesis.
Volume: 34
Issue: 2
Pages: 145-7
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Publication
16025118 | J:100461
First Author: Gounari F
Year: 2005
Journal: Nat Immunol
Title: Loss of adenomatous polyposis coli gene function disrupts thymic development.
Volume: 6
Issue: 8
Pages: 800-9
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Publication
12615699 | J:82288
First Author: Yamada T
Year: 2003
Journal: Cancer Res
Title: Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Volume: 63
Issue: 5
Pages: 895-901
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Publication
10346819 | J:55416
First Author: Smits R
Year: 1999
Journal: Genes Dev
Title: Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development.
Volume: 13
Issue: 10
Pages: 1309-21
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Publication
26085645 | J:222548
First Author: Hickman TT
Year: 2015
Journal: J Neurosci
Title: Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing.
Volume: 35
Issue: 24
Pages: 9236-45
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Publication
1541640 | J:1879
First Author: Moser AR
Year: 1992
Journal: J Cell Biol
Title: The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.
Volume: 116
Issue: 6
Pages: 1517-26
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Publication
8978062 | J:37224
First Author: Gould KA
Year: 1996
Journal: Genetics
Title: Mom1 is a semi-dominant modifier of intestinal adenoma size and multiplicity in Min/+ mice.
Volume: 144
Issue: 4
Pages: 1769-76
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Publication
12359746 | J:79690
First Author: Koratkar R
Year: 2002
Journal: Cancer Res
Title: The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.
Volume: 62
Issue: 19
Pages: 5413-7
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Publication
12907628 | J:85697
First Author: Czarnomska A
Year: 2003
Journal: Cancer Res
Title: Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland.
Volume: 63
Issue: 15
Pages: 4533-7
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GO Term
GO:0005680 | anaphase-promoting complex
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Publication
11779834 | J:73854
First Author: Silverman KA
Year: 2002
Journal: Genome Res
Title: Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.
Volume: 12
Issue: 1
Pages: 88-97
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Publication
8978063 | J:37223
First Author: Gould KA
Year: 1996
Journal: Genetics
Title: Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.
Volume: 144
Issue: 4
Pages: 1777-85
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Publication
23658527 | J:197133
First Author: Atlasi Y
Year: 2013
Journal: PLoS Genet
Title: Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.
Volume: 9
Issue: 5
Pages: e1003424
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Publication
9288104 | J:42722
First Author: Cormier RT
Year: 1997
Journal: Nat Genet
Title: Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis.
Volume: 17
Issue: 1
Pages: 88-91
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Publication
24934177 | J:302752
First Author: Mohn JL
Year: 2014
Journal: Mol Psychiatry
Title: Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
Volume: 19
Issue: 10
Pages: 1133-42
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Publication
10919675 | J:63662
First Author: Cormier RT
Year: 2000
Journal: Cancer Res
Title: Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
Volume: 60
Issue: 14
Pages: 3965-70
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Publication
21204268 | J:232020
First Author: Ermakova O
Year: 2011
Journal: EMBO Mol Med
Title: Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
Volume: 3
Issue: 1
Pages: 50-66
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Publication
17525738 | -
First Author: Xu X
Year: 2007
Journal: Oncogene
Title: Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer.
Volume: 26
Issue: 52
Pages: 7371-9
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Protein Domain
IPR026828 | Suppressor_APCD_1/2
Type: Family
Description: This entry consists of the suppressor APC domain-containing protein 1 and 2 (SAPCD1 and SAPCD2). SAPCD2 is expressed in many primary gastric carcinoma. It is expressed preferentially in M and G1 phases, compared to S and G2 phases [].
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Publication
15967128 | J:104334
First Author: Chen WT
Year: 2005
Journal: Mol Imaging
Title: Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe.
Volume: 4
Issue: 1
Pages: 67-74
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Publication
38632995 | J:347639
First Author: Xie J
Year: 2024
Journal: iScience
Title: Extracellular vesicles-derived CXCL4 is a candidate serum tumor biomarker for colorectal cancer.
Volume: 27
Issue: 4
Pages: 109612
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Publication
22689992 | J:185588
First Author: Khazaie K
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.
Volume: 109
Issue: 26
Pages: 10462-7
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Publication
19570783 | J:150344
First Author: Gounaris E
Year: 2009
Journal: Cancer Res
Title: T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.
Volume: 69
Issue: 13
Pages: 5490-7
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Publication
21216893 | J:169312
First Author: Cheon EC
Year: 2011
Journal: Cancer Res
Title: Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Volume: 71
Issue: 5
Pages: 1627-36
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Publication
22072302 | J:321173
First Author: Cheon EC
Year: 2012
Journal: J Gastrointest Surg
Title: Genetic deletion of 5-lipoxygenase increases tumor-infiltrating macrophages in Apc(Δ468) mice.
Volume: 16
Issue: 2
Pages: 389-93
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Publication
18698347 | J:140593
First Author: Gounaris E
Year: 2008
Journal: PLoS One
Title: Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
Volume: 3
Issue: 8
Pages: e2916
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Allele
Apc<tm2Tno> | MGI:2678005
Name: APC, WNT signaling pathway regulator; targeted mutation 2, Tetsuo Noda
Allele Type: Targeted
Attribute String: Humanized sequence, Null/knockout
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Publication
18264107 | J:148161
First Author: Akyol A
Year: 2008
Journal: Nat Methods
Title: Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene.
Volume: 5
Issue: 3
Pages: 231-3
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Publication
15640937 | J:96288
First Author: Hlubinová K
Year: 2004
Journal: Neoplasma
Title: Influence of diet containing lyophilized Enterococcus faecium M-74 with organic selenium on tumor incidence in Apc1638N mice.
Volume: 51
Issue: 5
Pages: 341-4
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Publication
32771388 | J:324446
First Author: Hayashi Y
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging.
Volume: 11
Issue: 1
Pages: 117-145
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Publication
17113391 | J:116121
First Author: Drabek K
Year: 2006
Journal: Curr Biol
Title: Role of CLASP2 in microtubule stabilization and the regulation of persistent motility.
Volume: 16
Issue: 22
Pages: 2259-64
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Publication
23407966 | J:194259
First Author: Lang J
Year: 2013
Journal: J Neurosci
Title: Adenomatous polyposis coli regulates oligodendroglial development.
Volume: 33
Issue: 7
Pages: 3113-30
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Publication
7954427 | J:21369
First Author: Luongo C
Year: 1994
Journal: Cancer Res
Title: Loss of Apc+ in intestinal adenomas from Min mice.
Volume: 54
Issue: 22
Pages: 5947-52
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Publication
9865728 | J:51518
First Author: Yang K
Year: 1998
Journal: Cancer Res
Title: Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis.
Volume: 58
Issue: 24
Pages: 5713-7
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Publication
16950562 | J:120014
First Author: Hu Y
Year: 2007
Journal: Cancer Lett
Title: Defective acute apoptotic response to genotoxic carcinogen in small intestine of APC(Min/+) mice is restored by sulindac.
Volume: 248
Issue: 2
Pages: 234-44
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Publication
9110402 | J:40100
First Author: Bilger A
Year: 1996
Journal: Semin Cancer Biol
Title: Manipulation of the mouse germline in the study of Min-induced neoplasia.
Volume: 7
Issue: 5
Pages: 249-60
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Title: Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice.
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First Author: Gould KA
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Journal: Proc Natl Acad Sci U S A
Title: Localized gene action controlling intestinal neoplasia in mice.
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First Author: Xia L
Year: 1995
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Title: Evidence for a novel exon in the coding region of the adenomatous polyposis coli (APC) gene.
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First Author: Croes L
Year: 2019
Journal: Cancers (Basel)
Title: Determination of the Potential Tumor-Suppressive Effects of Gsdme in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model.
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Journal: Genes Dev
Title: Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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