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Search results 201 to 283 out of 283 for Cul4a

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Type Details Score
Publication
23055941 | J:193640
First Author: Lo JC
Year: 2012
Journal: PLoS Genet
Title: RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.
Volume: 8
Issue: 10
Pages: e1002969
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Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Allele
Cul4a<tm1.1Pra> | MGI:5003269
Name: cullin 4A; targeted mutation 1.1, Pradip Raychaudhuri
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
26104890 | J:305886
First Author: Wang Y
Year: 2015
Journal: Zhongguo Fei Ai Za Zhi
Title: PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.
Volume: 18
Issue: 6
Pages: 345-50
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Publication
17452440 | -
First Author: Pick E
Year: 2007
Journal: Mol Cell Biol
Title: Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.
Volume: 27
Issue: 13
Pages: 4708-19
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GO Term
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex
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Protein
Q9D0A0
Organism: Mus musculus/domesticus
Length: 550  
Fragment?: false
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Protein
A0A0U1RNK0
Organism: Mus musculus/domesticus
Length: 72  
Fragment?: true
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Protein
D3YXC0
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: false
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Protein
D3Z6F8
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: false
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Publication
12589545 | -
First Author: Levin I
Year: 2003
Journal: Theor Appl Genet
Title: The tomato dark green mutation is a novel allele of the tomato homolog of the DEETIOLATED1 gene.
Volume: 106
Issue: 3
Pages: 454-60
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Publication
14751237 | -
First Author: Inoki T
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Human DDB2 splicing variants are dominant negative inhibitors of UV-damaged DNA repair.
Volume: 314
Issue: 4
Pages: 1036-43
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Publication
26205499 | -
First Author: Qiao S
Year: 2015
Journal: Biochem J
Title: DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells.
Volume: 469
Issue: 3
Pages: 469-80
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Publication
24563205 | -
First Author: Irigoyen ML
Year: 2014
Journal: Plant Cell
Title: Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis.
Volume: 26
Issue: 2
Pages: 712-28
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Publication
19295130 | -
First Author: Olma MH
Year: 2009
Journal: J Cell Sci
Title: An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.
Volume: 122
Issue: Pt 7
Pages: 1035-44
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Protein Domain
IPR019138 | De-etiolated_protein_1_Det1
Type: Family
Description: This entry represents Det1 family proteins []. Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Associated 1), is a member of the UBE2E group of canonical ubiquitin conjugating enzymes and modulates Cul4A function [].
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Protein Domain
IPR033312 | DDB2
Type: Family
Description: DNA damage-binding protein 2 (DDB2) is required for DNA repair. It binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair []. It is also involved in the initiation of nucleotide excision repair via an ubiquitin ligase complex together with DDB1 and CUL4A (cullin 4A) [].
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Protein Domain
IPR033575 | DDA1
Type: Family
Description: DDA1 is a core subunit of multiple Cul4-based E3 ligases (CRL4s), involved in ubiquitination and subsequent proteasomal degradation of target proteins, which regulate key developmental and stress responses in eukaryotes [, ]. In mammals, DDA1 binds to DET1 and DDB1 to form DDD complexes, which recruit specific ubiquitin-conjugating UBE2E enzymes to form DDD-E2 complexes []. The DDD-E2 complex provides a platform for interaction with Cul4A and beta-transducing (also called WD40) repeat proteins. DDA1 is conserved in higher eukaryotes, including Arabidopsis [].
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Protein Domain
IPR018276 | DDA1_N
Type: Domain
Description: This entry represents the N-terminal domain of DDA1 (DET1- and DDB1-associated protein 1) ubiquitin ligase, which binds strongly with Det1 (De-etiolated 1) and DDB1 (Damaged DNA binding protein 1 associated 1). Together DDA1, DDB1 and Det1 form the DDD core complex, which recruits a specific UBE2E enzyme to form specific DDD-E2 complexes []. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins. These proteins may be involved in ubiquitination and subsequent proteasomal degradation of target proteins.
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Protein
Q9D9Z5
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
D3YXY5
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Publication
20351176 | J:162585
First Author: Roy N
Year: 2010
Journal: Mol Cell Biol
Title: DDB2, an essential mediator of premature senescence.
Volume: 30
Issue: 11
Pages: 2681-92
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Publication
30405104 | J:267547
First Author: Cui CP
Year: 2018
Journal: Nat Commun
Title: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.
Volume: 9
Issue: 1
Pages: 4648
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Publication
32160551 | J:288273
First Author: Yasukawa T
Year: 2020
Journal: Cell Rep
Title: NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.
Volume: 30
Issue: 10
Pages: 3478-3491.e6
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Protein Coding Gene
MGI:1930751 | Trpc4ap
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17635991 | J:125000
First Author: Luijsterburg MS
Year: 2007
Journal: J Cell Sci
Title: Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.
Volume: 120
Issue: Pt 15
Pages: 2706-16
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Publication
35799276 | J:338152
First Author: Wang W
Year: 2022
Journal: Stem Cell Res Ther
Title: KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA.
Volume: 13
Issue: 1
Pages: 290
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Publication
33895141 | J:306223
   
First Author: Siswanto FM
Year: 2021
Journal: J Biol Chem
Title: Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2.
Pages: 100704
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Protein Coding Gene
MGI:1347046 | Cop1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913277 | Crbn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923625 | Det1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32956847 | J:298981
 
First Author: Mittenbühler MJ
Year: 2020
Journal: Mol Metab
Title: Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo.
Volume: 42
Pages: 101085
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Protein
Q4FZK4
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein Coding Gene
MGI:2141180 | Glmn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344363 | Arih1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924093 | Dtl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919241 | Ercc8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1355314 | Ddb2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919834 | Cul4b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99J79
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
A2AGR6
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
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Protein Coding Gene
MGI:1202384 | Ddb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Pseudogene
MGI:3710517 | Rbx1-ps
Type: pseudogene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891829 | Rbx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104565 | Cdkn1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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