|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 201 to 300 out of 1119 for Htt

0.011s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
First Author: Ferrari Bardile C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease.
Volume: 116
Issue: 19
Pages: 9622-9627
Publication
First Author: Callahan JW
Year: 2022
Journal: J Neurosci
Title: Dysregulation of the Basal Ganglia Indirect Pathway in Early Symptomatic Q175 Huntington's Disease Mice.
Volume: 42
Issue: 10
Pages: 2080-2102
Publication
First Author: Wong YC
Year: 2014
Journal: J Neurosci
Title: The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Volume: 34
Issue: 4
Pages: 1293-305
Publication
First Author: Kovalenko M
Year: 2012
Journal: PLoS One
Title: Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice.
Volume: 7
Issue: 9
Pages: e44273
Publication
First Author: Tourette C
Year: 2014
Journal: PLoS Biol
Title: The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Volume: 12
Issue: 6
Pages: e1001895
Publication  
First Author: Agostoni E
Year: 2016
Journal: Front Cell Neurosci
Title: Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice.
Volume: 10
Pages: 110
Publication
First Author: Chaturvedi RK
Year: 2012
Journal: Hum Mol Genet
Title: Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.
Volume: 21
Issue: 15
Pages: 3474-88
Publication
First Author: Tallaksen-Greene SJ
Year: 2005
Journal: Neuroscience
Title: Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice.
Volume: 131
Issue: 4
Pages: 843-52
Publication
First Author: Ju TC
Year: 2014
Journal: Biochim Biophys Acta
Title: AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.
Volume: 1842
Issue: 9
Pages: 1668-80
Publication
First Author: Chiang MC
Year: 2007
Journal: Hum Mol Genet
Title: Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
Volume: 16
Issue: 5
Pages: 483-98
Publication
First Author: Cheng HM
Year: 2015
Journal: PLoS Genet
Title: Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.
Volume: 11
Issue: 3
Pages: e1005043
Publication
First Author: Wade BE
Year: 2014
Journal: J Neurosci
Title: Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.
Volume: 34
Issue: 25
Pages: 8411-22
Publication
First Author: McClory H
Year: 2018
Journal: Sci Rep
Title: The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
Volume: 8
Issue: 1
Pages: 8000
Publication
First Author: Mason MA
Year: 2020
Journal: Sci Rep
Title: Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models.
Volume: 10
Issue: 1
Pages: 14057
Publication
First Author: Parsons MP
Year: 2014
Journal: J Biol Chem
Title: Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin.
Volume: 289
Issue: 6
Pages: 3518-28
Publication
First Author: Soldati C
Year: 2013
Journal: J Neurochem
Title: Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease.
Volume: 124
Issue: 3
Pages: 418-30
Publication  
First Author: Yao J
Year: 2014
Journal: Mol Cell Neurosci
Title: Huntingtin is associated with cytomatrix proteins at the presynaptic terminal.
Volume: 63
Pages: 96-100
Publication
First Author: Marco S
Year: 2013
Journal: Nat Med
Title: Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Volume: 19
Issue: 8
Pages: 1030-8
Publication
First Author: McFarland KN
Year: 2014
Journal: Hum Mol Genet
Title: MeCP2: a novel Huntingtin interactor.
Volume: 23
Issue: 4
Pages: 1036-44
Publication
First Author: Pan Y
Year: 2018
Journal: J Biol Chem
Title: The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.
Volume: 293
Issue: 30
Pages: 11850-11866
Publication
First Author: Tang B
Year: 2012
Journal: Hum Mol Genet
Title: Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease.
Volume: 21
Issue: 14
Pages: 3097-111
Publication  
First Author: Swarnkar S
Year: 2015
Journal: Neurobiol Dis
Title: Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Volume: 82
Pages: 66-77
Publication
First Author: Lee H
Year: 2020
Journal: Neuron
Title: Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation.
Volume: 107
Issue: 5
Pages: 891-908.e8
Publication
First Author: Callahan JW
Year: 2024
Journal: Cell Rep
Title: Movement-related increases in subthalamic activity optimize locomotion.
Volume: 43
Issue: 8
Pages: 114495
Publication
First Author: Morfini GA
Year: 2009
Journal: Nat Neurosci
Title: Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.
Volume: 12
Issue: 7
Pages: 864-71
Publication
First Author: Goold R
Year: 2021
Journal: Cell Rep
Title: FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Volume: 36
Issue: 9
Pages: 109649
Publication
First Author: Choudhury KR
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.
Volume: 456
Issue: 1
Pages: 66-73
Publication
First Author: Dietrich P
Year: 2009
Journal: Hum Mol Genet
Title: Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages.
Volume: 18
Issue: 1
Pages: 142-50
Publication
First Author: Gerson JE
Year: 2020
Journal: Hum Mol Genet
Title: Ubiquilin-2 differentially regulates polyglutamine disease proteins.
Volume: 29
Issue: 15
Pages: 2596-2610
Publication
First Author: Jiang M
Year: 2020
Journal: Hum Mol Genet
Title: Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Volume: 29
Issue: 8
Pages: 1340-1352
Publication
First Author: Caviston JP
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Volume: 104
Issue: 24
Pages: 10045-50
Publication
First Author: Cho KJ
Year: 2009
Journal: Neuroscience
Title: Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease.
Volume: 163
Issue: 4
Pages: 1128-34
Publication
First Author: Crook ZR
Year: 2011
Journal: Neuron
Title: Huntington's disease: can mice lead the way to treatment?
Volume: 69
Issue: 3
Pages: 423-35
Publication  
First Author: Pan Y
Year: 2016
Journal: Sci Rep
Title: Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity.
Volume: 6
Pages: 31022
Publication
First Author: Zhao Z
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.
Volume: 114
Issue: 17
Pages: 4489-4494
Publication
First Author: Keryer G
Year: 2011
Journal: J Clin Invest
Title: Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
Volume: 121
Issue: 11
Pages: 4372-82
Publication
First Author: Di Pardo A
Year: 2020
Journal: Hum Mol Genet
Title: Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.
Volume: 29
Issue: 3
Pages: 418-431
Publication
First Author: Gafni J
Year: 2004
Journal: J Biol Chem
Title: Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.
Volume: 279
Issue: 19
Pages: 20211-20
Publication
First Author: Hachigian LJ
Year: 2017
Journal: Cell Rep
Title: Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched Transcription Factor Foxp2.
Volume: 21
Issue: 10
Pages: 2688-2695
Publication
First Author: Miller JP
Year: 2012
Journal: PLoS Genet
Title: A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Volume: 8
Issue: 11
Pages: e1003042
Publication
First Author: Pancani T
Year: 2023
Journal: Nat Commun
Title: Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington's disease model mice.
Volume: 14
Issue: 1
Pages: 1398
Publication
First Author: Louis Sam Titus ASC
Year: 2017
Journal: J Neurosci
Title: Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease.
Volume: 37
Issue: 27
Pages: 6575-6587
Publication
First Author: de Souza JM
Year: 2020
Journal: Mol Brain
Title: mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease.
Volume: 13
Issue: 1
Pages: 118
Publication
First Author: Loupe JM
Year: 2020
Journal: Hum Mol Genet
Title: Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Volume: 29
Issue: 18
Pages: 3044-3053
Publication  
First Author: Voelkl K
Year: 2023
Journal: Life Sci Alliance
Title: Neuroprotective effects of hepatoma-derived growth factor in models of Huntington's disease.
Volume: 6
Issue: 11
Publication
First Author: Sanders SS
Year: 2015
Journal: Dev Biol
Title: Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.
Volume: 397
Issue: 2
Pages: 257-66
Publication
First Author: Plotkin JL
Year: 2014
Journal: Neuron
Title: Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease.
Volume: 83
Issue: 1
Pages: 178-88
Publication
First Author: Näf D
Year: 2001
Journal: Hum Mol Genet
Title: Mouse models for the Wolf-Hirschhorn deletion syndrome.
Volume: 10
Issue: 2
Pages: 91-8
Publication
First Author: Rué L
Year: 2016
Journal: J Clin Invest
Title: Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.
Volume: 126
Issue: 11
Pages: 4319-4330
Publication
First Author: Yu X
Year: 2020
Journal: Neuron
Title: Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable.
Volume: 108
Issue: 6
Pages: 1146-1162.e10
Publication
First Author: Kaltenbach LS
Year: 2007
Journal: PLoS Genet
Title: Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Volume: 3
Issue: 5
Pages: e82
Publication  
First Author: Voelkl K
Year: 2022
Journal: Front Neurosci
Title: Distinct histological alterations of cortical interneuron types in mouse models of Huntington's disease.
Volume: 16
Pages: 1022251
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lin B
Year: 1994
Journal: Hum Mol Genet
Title: Sequence of the murine Huntington disease gene: evidence for conservation, alternate splicing and polymorphism in a triplet (CCG) repeat [corrected].
Volume: 3
Issue: 1
Pages: 85-92
Publication
First Author: Barnes GT
Year: 1994
Journal: Somat Cell Mol Genet
Title: Mouse Huntington's disease gene homolog (Hdh).
Volume: 20
Issue: 2
Pages: 87-97
Publication
First Author: Trottier Y
Year: 1995
Journal: Nat Genet
Title: Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form.
Volume: 10
Issue: 1
Pages: 104-10
Publication
First Author: Lin B
Year: 1995
Journal: Genomics
Title: Structural analysis of the 5' region of mouse and human Huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms.
Volume: 25
Issue: 3
Pages: 707-15
Publication  
First Author: MacDonald ME
Year: 1996
Journal: Cold Spring Harb Symp Quant Biol
Title: Targeted inactivation of the mouse Huntington's disease gene homolog Hdh.
Volume: 61
Pages: 627-38
Publication
First Author: Reiner A
Year: 2001
Journal: J Neurosci
Title: Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice.
Volume: 21
Issue: 19
Pages: 7608-19
Publication
First Author: Dragatsis I
Year: 2000
Journal: Nat Genet
Title: Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.
Volume: 26
Issue: 3
Pages: 300-6
Publication
First Author: Brustovetsky N
Year: 2005
Journal: J Neurochem
Title: Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's Disease.
Volume: 93
Issue: 6
Pages: 1361-70
Publication
First Author: Wheeler VC
Year: 2000
Journal: Hum Mol Genet
Title: Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice.
Volume: 9
Issue: 4
Pages: 503-13
Publication
First Author: Langfelder P
Year: 2018
Journal: PLoS One
Title: MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.
Volume: 13
Issue: 1
Pages: e0190550
Publication
First Author: Snider BJ
Year: 2003
Journal: Neuroscience
Title: Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults.
Volume: 120
Issue: 3
Pages: 617-25
Publication
First Author: Langfelder P
Year: 2016
Journal: Nat Neurosci
Title: Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.
Volume: 19
Issue: 4
Pages: 623-33
Publication
First Author: Guidetti P
Year: 2006
Journal: Neurobiol Dis
Title: Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Volume: 23
Issue: 1
Pages: 190-7
Publication
First Author: Kuhn A
Year: 2007
Journal: Hum Mol Genet
Title: Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
Volume: 16
Issue: 15
Pages: 1845-61
Publication
First Author: Namura S
Year: 2002
Journal: Neurobiol Dis
Title: The HD mutation does not alter neuronal death in the striatum of Hdh(Q92) knock-in mice after mild focal ischemia.
Volume: 11
Issue: 1
Pages: 147-54
Publication
First Author: Trueman RC
Year: 2009
Journal: Behav Brain Res
Title: Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease.
Volume: 203
Issue: 2
Pages: 215-22
Publication
First Author: Trueman RC
Year: 2008
Journal: Behav Brain Res
Title: Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT).
Volume: 189
Issue: 2
Pages: 317-24
Publication
First Author: Trueman RC
Year: 2007
Journal: Eur J Neurosci
Title: The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's disease.
Volume: 25
Issue: 2
Pages: 551-8
Publication
First Author: Puigdellívol M
Year: 2015
Journal: Hum Mol Genet
Title: A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.
Volume: 24
Issue: 25
Pages: 7265-85
Publication
First Author: Reis SA
Year: 2011
Journal: Hum Mol Genet
Title: Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
Volume: 20
Issue: 12
Pages: 2344-55
Publication
First Author: O'Reilly D
Year: 2023
Journal: Mol Ther
Title: Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Volume: 31
Issue: 6
Pages: 1661-1674
Publication
First Author: Cherubini M
Year: 2015
Journal: Biochim Biophys Acta
Title: Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease.
Volume: 1852
Issue: 10 Pt A
Pages: 2145-60
Publication  
First Author: Ribeiro M
Year: 2014
Journal: Free Radic Biol Med
Title: Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington's disease knock-in striatal cells.
Volume: 74
Pages: 129-44
Publication
First Author: Cariulo C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.
Volume: 114
Issue: 50
Pages: E10809-E10818
Publication
First Author: Mochel F
Year: 2012
Journal: J Biol Chem
Title: Early alterations of brain cellular energy homeostasis in Huntington disease models.
Volume: 287
Issue: 2
Pages: 1361-70
Publication
First Author: Wheeler VC
Year: 2002
Journal: Hum Mol Genet
Title: Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice.
Volume: 11
Issue: 6
Pages: 633-40
Publication  
First Author: Du Z
Year: 2016
Journal: Neuroscience
Title: Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease.
Volume: 329
Pages: 363-79
Publication
First Author: Martinez-Vicente M
Year: 2010
Journal: Nat Neurosci
Title: Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
Volume: 13
Issue: 5
Pages: 567-76
Publication  
First Author: Yhnell E
Year: 2016
Journal: Exp Neurol
Title: Cognitive training modifies disease symptoms in a mouse model of Huntington's disease.
Volume: 282
Pages: 19-26