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Search results 201 to 288 out of 288 for Map3k8

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Type Details Score
Publication
24713702 | J:214118
First Author: Rowley SM
Year: 2014
Journal: J Biol Chem
Title: Tumor progression locus 2 (Tpl2) kinase promotes chemokine receptor expression and macrophage migration during acute inflammation.
Volume: 289
Issue: 22
Pages: 15788-97
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Publication
35082159 | J:322244
First Author: Blair L
Year: 2022
Journal: J Immunol
Title: TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages.
Volume: 208
Issue: 4
Pages: 941-954
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Publication
29562203 | J:272415
First Author: O'Reilly LA
Year: 2018
Journal: Immunity
Title: Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Volume: 48
Issue: 3
Pages: 570-583.e8
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Publication
22124325 | J:181776
First Author: Gugasyan R
Year: 2012
Journal: EMBO J
Title: The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.
Volume: 31
Issue: 3
Pages: 692-706
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Publication
8107195 | J:16804
First Author: Justice MJ
Year: 1994
Journal: J Virol
Title: Identification of Evi-3, a novel common site of retroviral integration in mouse AKXD B-cell lymphomas.
Volume: 68
Issue: 3
Pages: 1293-300
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Publication
18187448 | J:131083
First Author: Rousseau S
Year: 2008
Journal: J Cell Sci
Title: TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Volume: 121
Issue: Pt 2
Pages: 149-54
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Publication
22988300 | J:189231
First Author: Roget K
Year: 2012
Journal: Mol Cell Biol
Title: IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.
Volume: 32
Issue: 22
Pages: 4684-90
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Publication
9070650 | J:38895
First Author: Liao X
Year: 1997
Journal: Oncogene
Title: Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins.
Volume: 14
Issue: 9
Pages: 1023-9
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Publication
24912162 | J:211623
First Author: Ben-Addi A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.
Volume: 111
Issue: 23
Pages: E2394-403
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Publication
16291755 | J:116388
First Author: Eliopoulos AG
Year: 2006
Journal: J Biol Chem
Title: The tyrosine kinase Syk regulates TPL2 activation signals.
Volume: 281
Issue: 3
Pages: 1371-80
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Publication
12486099 | J:108572
First Author: Kontoyiannis D
Year: 2002
Journal: J Exp Med
Title: Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease.
Volume: 196
Issue: 12
Pages: 1563-74
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Publication
18855897 | J:141097
First Author: Craig EA
Year: 2008
Journal: Dev Dyn
Title: MAP3Ks as central regulators of cell fate during development.
Volume: 237
Issue: 11
Pages: 3102-14
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Publication
9151674 | J:40187
First Author: Miner JH
Year: 1997
Journal: J Cell Biol
Title: The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Volume: 137
Issue: 3
Pages: 685-701
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Publication
1354644 | J:1701
First Author: Justice MJ
Year: 1992
Journal: Genomics
Title: A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.
Volume: 13
Issue: 4
Pages: 1281-8
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Publication
8626800 | J:37068
First Author: Wang Y
Year: 1996
Journal: J Biol Chem
Title: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
Volume: 271
Issue: 8
Pages: 4468-76
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Publication
27022143 | J:233073
First Author: de Valle E
Year: 2016
Journal: J Exp Med
Title: NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
Volume: 213
Issue: 4
Pages: 621-41
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Publication
23070814 | J:188254
First Author: Budry L
Year: 2012
Journal: Genes Dev
Title: The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling.
Volume: 26
Issue: 20
Pages: 2299-310
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
33443087 | J:303906
First Author: Zannikou M
Year: 2021
Journal: J Immunol
Title: MAP3K8 Regulates Cox-2-Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis.
Volume: 206
Issue: 3
Pages: 607-620
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Pathway
R-MMU-5684264 | MAP3K8 (TPL2)-dependent MAPK1/3 activation
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Allele
Tg(Alb-Map3k8)1Zgs | MGI:7492359
Name: transgene insertion 1, Zhi-Gang She
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
15169888 | -
First Author: Lang V
Year: 2004
Journal: Mol Cell Biol
Title: ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Volume: 24
Issue: 12
Pages: 5235-48
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Publication
15670770 | -
First Author: Chan H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: TRAF-dependent association of protein kinase Tpl2/COT1 (MAP3K8) with CD40.
Volume: 328
Issue: 1
Pages: 198-205
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Protein Domain
IPR017424 | MAPKKK8
Type: Family
Description: This entry represents mitogen-activated protein kinase kinase kinase 8 (MAP3K8 or COT or TPL2) (), which plays a role in the cell cycle. MAP3K8 is required for TLR4 activation of the MEK/ERK pathway. MAP3K8 is able to activate NF-kappa-B 1 (NFKB1) by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105 []. MAP3K8 forms a ternary complex with NFKB1 and TNIP2 []. MAP3K8 is recruited to the CD40 complex via a mechanism dependent on TRAF-binding sites in CD40 [].
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Allele
Tg(Lck-Map3k8)3456Ngc | MGI:2388710
Name: transgene insertion 3456, Neal G Copeland
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
9087424 | J:39450
First Author: Ceci JD
Year: 1997
Journal: Genes Dev
Title: Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation.
Volume: 11
Issue: 6
Pages: 688-700
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Genotype
Genotype
Symbol: Tg(Lck-Map3k8)3456Ngc/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
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Protein
Q07174
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Publication
30463015 | J:270675
First Author: Wehde BL
Year: 2018
Journal: Cell Rep
Title: Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression.
Volume: 25
Issue: 8
Pages: 2192-2207.e5
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Protein Coding Gene
MGI:2386643 | Tnip2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q99JG7
Organism: Mus musculus/domesticus
Length: 430  
Fragment?: false
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Protein
Q3U086
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein
Q3UEB8
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
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Protein Coding Gene
MGI:2144023 | Fbxw11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97312 | Nfkb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q5SRY7
Organism: Mus musculus/domesticus
Length: 542  
Fragment?: false
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Protein
P25799
Organism: Mus musculus/domesticus
Length: 971  
Fragment?: false
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Protein Coding Gene
MGI:99484 | Chuk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338071 | Ikbkb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338074 | Ikbkg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O88522
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: false
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Protein
O88351
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
Q60680
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein Coding Gene
MGI:103575 | Skp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349658 | Cul1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WTX6
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Protein
Q9WTX5
Organism: Mus musculus/domesticus
Length: 163  
Fragment?: false
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Protein Coding Gene
MGI:1925544 | Rps27a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98887 | Uba52
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98888 | Ubb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98889 | Ubc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62984
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
P0CG50
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P62983
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
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Protein
P0CG49
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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