| Type |
Details |
Score |
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
35 |
| Description: |
E3 ubiquitin-protein ligase RNF13 |
| Type: |
chain |
| End: |
381 |
|
•
•
•
•
•
|
| Allele |
| Name: |
ring finger protein 13; targeted mutation 1, Xiang Gao |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
| Allele |
| Name: |
ring finger protein 13; targeted mutation 1.1, Xiang Gao |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
96
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bocock JP |
| Year: |
2010 |
| Journal: |
Traffic |
| Title: |
Nuclear targeting of an endosomal E3 ubiquitin ligase. |
| Volume: |
11 |
| Issue: |
6 |
| Pages: |
756-66 |
|
•
•
•
•
•
|
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Park M |
| Year: |
2005 |
| Journal: |
J Cell Biol |
| Title: |
AtRMR1 functions as a cargo receptor for protein trafficking to the protein storage vacuole. |
| Volume: |
170 |
| Issue: |
5 |
| Pages: |
757-67 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Arshad M |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway. |
| Volume: |
288 |
| Issue: |
12 |
| Pages: |
8726-8736 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Neutzner A |
| Year: |
2011 |
| Journal: |
J Biol Chem |
| Title: |
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. |
| Volume: |
286 |
| Issue: |
10 |
| Pages: |
8633-8643 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This PA domain is found in ZNRF4 /RNF13/RNF167 from animals and RMR1-6 from Arabidopsis. These proteins contain a C3H2C3 RING finger and some of them are predicted to be membrane-anchored RING finger ubiquitin ligases [, ]. ZNRF4 is an ER-localized RING finger ubiquitin ligase and a regulator of calnexin stability and ER homeostasis []. RNF13 is highly enriched in ER and serves as a critical mediator for facilitating ER stress-induced apoptosis through the activation of the IRE1alpha-TRAF2-JNK signaling pathway []. RMR1 (also known as ReMembR-H2) is a sorting receptor involved in transport of storage proteins to protein storage vacuoles [].The significance of the PA domain to these proteins has not been ascertained. It may be a protein-protein interaction domain. At peptidase active sites, the PA domain may participate in substrate binding and/or promoting conformational changes, which influence the stability and accessibility of the site to substrate. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
244
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
131
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
166
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luo X |
| Year: |
2001 |
| Journal: |
Trends Biochem Sci |
| Title: |
The protease-associated domain: a homology domain associated with multiple classes of proteases. |
| Volume: |
26 |
| Issue: |
3 |
| Pages: |
147-8 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
327
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
352
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
268
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
347
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Church DM |
| Year: |
2009 |
| Journal: |
PLoS Biol |
| Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
e1000112 |
|
•
•
•
•
•
|