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Search results 301 to 400 out of 534 for Cdc20

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Type Details Score
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
Publication
First Author: Mansfeld J
Year: 2011
Journal: Nat Cell Biol
Title: APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.
Volume: 13
Issue: 10
Pages: 1234-43
Protein Domain
Type: Family
Description: Human ANAPC15 is a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, it plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C; it is not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating to the responsiveness of the spindle assembly checkpoint. It also required for degradation of CDC20 [].
Protein
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
Protein Domain
Type: Domain
Description: This entry represents the C terminus of the sperm centrosome protein speriolin [, ].Speriolin is a sperm centrosome protein []that form a complex with CDC20, CDC27 and TUBG1. It interacts with Cdc20 and is only detected in testis in humans [, ]. The function of speriolin and speriolin-like proteins is unknown.
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
Publication
First Author: Kitagawa K
Year: 2003
Journal: Mol Cell
Title: Requirement of Skp1-Bub1 interaction for kinetochore-mediated activation of the spindle checkpoint.
Volume: 11
Issue: 5
Pages: 1201-13
Publication
First Author: Yamaguchi K
Year: 1999
Journal: Cancer Lett
Title: Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines.
Volume: 139
Issue: 2
Pages: 183-7
Publication
First Author: Cahill DP
Year: 1998
Journal: Nature
Title: Mutations of mitotic checkpoint genes in human cancers.
Volume: 392
Issue: 6673
Pages: 300-3
Publication
First Author: Burton JL
Year: 2007
Journal: Genes Dev
Title: Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint.
Volume: 21
Issue: 6
Pages: 655-67
Publication
First Author: Izumi H
Year: 2009
Journal: Oncogene
Title: BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
Volume: 28
Issue: 31
Pages: 2806-20
Protein Domain
Type: Family
Description: This represents the mitotic checkpoint serine/threonine-protein kinase Bub1. Saccharomyces cerevisiae Bub1 has a paralogue, Mad3, which is also included in this entry. Bub1 forms a complex with Mad1 and Bub3 that is crucial for preventing cell cycle progression into anaphase in the presence of spindle damage [], while Mad3 is a component of the spindle-assembly complex consisting of Mad2, Mad3, Bub3 and Cdc20 []. Mad3 contains a D-box and two KEN- boxes, which function together to mediate Cdc20-Mad3 interaction. Mad3 and an anaphase-promoting complex (APC) substrate, Hsl1, compete for Cdc20 binding in a D-box- and KEN-box-dependent manner [].Similar to its yeast homologues, human Bub1 is a critical component of the mitotic checkpoint that delays the onset of anaphase until all chromosomes have established bipolar attachment to the microtubules. In interphase cells it localises to centrosomes and suppresses centrosome amplification via regulating Plk1 activity []. Mutations in the human Bub1 gene have been linked to cancers [, ].
Protein
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 294  
Fragment?: false
Publication
First Author: Wassmann K
Year: 2003
Journal: EMBO J
Title: Mad2 phosphorylation regulates its association with Mad1 and the APC/C.
Volume: 22
Issue: 4
Pages: 797-806
Protein Domain
Type: Family
Description: This family consists of pindle assembly checkpoint protein Mad1. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in Saccharomyces cerevisiae and higher eukaryotes. In Saccharomyces cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated [].
Protein
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
Publication
First Author: Hardwick KG
Year: 2000
Journal: J Cell Biol
Title: MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.
Volume: 148
Issue: 5
Pages: 871-82
Protein
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
Publication
First Author: Hadjihannas MV
Year: 2012
Journal: EMBO Rep
Title: Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20.
Volume: 13
Issue: 4
Pages: 347-54
Publication
First Author: Schrock MS
Year: 2020
Journal: Semin Cancer Biol
Title: APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.
Volume: 67
Issue: Pt 2
Pages: 80-91
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
Publication
First Author: Yang M
Year: 2007
Journal: Cell
Title: p31comet blocks Mad2 activation through structural mimicry.
Volume: 131
Issue: 4
Pages: 744-55
Publication
First Author: Habu T
Year: 2002
Journal: EMBO J
Title: Identification of a MAD2-binding protein, CMT2, and its role in mitosis.
Volume: 21
Issue: 23
Pages: 6419-28
Publication
First Author: Chen RH
Year: 1999
Journal: Mol Biol Cell
Title: The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.
Volume: 10
Issue: 8
Pages: 2607-18
Publication
First Author: Bassermann F
Year: 2014
Journal: Biochim Biophys Acta
Title: The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.
Volume: 1843
Issue: 1
Pages: 150-62
Publication
First Author: Kops GJ
Year: 2010
Journal: J Cell Sci
Title: APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.
Volume: 123
Issue: Pt 10
Pages: 1623-33
Protein Domain
Type: Family
Description: This entry represents Mad1 and Cdc20-bound-Mad2 binding proteins that are involved in the cell-cycle surveillance mechanism called the spindle checkpoint []. This mechanism monitors the proper bipolar attachment of sister chromatids to spindle microtubules and ensures the fidelity of chromosome segregation during mitosis. A key player in mitosis is Mad2, which exhibits an unusual two-state behaviour. A Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerisation and converts Mad2 to a conformer amenable to Cdc20 binding. p31comet inactivates the checkpoint by binding to Mad1- or Cdc20-bound Mad2 in such a way as to stop Mad2 activation and to promote the dissociation of the Mad2-Cdc20 complex [].
Protein Domain
Type: Family
Description: The anaphase promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C consists of thirteen different subunits and, in somatic cells, has two co-activators: Cdc20 and Cdh1 (also known as Fzr1), which associate with the APC/C core at defined stages of the cell cycle. APC/C is only active between metaphase and the end of the next G1 phase. During this time, APC/CCdc20 initiates anaphase and mitotic exit,while APC/CCdh1 contributes to mitotic exit and establishment of a stable G1 state []. This entry represents the APC/C subunit 16 [].
Protein Domain
Type: Family
Description: Mad2 is a central component of the spindle assembly checkpoint, which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis [, ]. In Saccharomyces cerevisiae, it is a component of the mitotic checkpoint complex (MCC) which consists of MAD2, MAD3, BUB3 and CDC20, and of the MAD2-CDC20 subcomplex, both of which appear to be assembled during mitoisis independently of the kinetochore. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 [, , ].
Protein
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 395  
Fragment?: false
Publication
First Author: Diao Y
Year: 2012
Journal: Cell Stem Cell
Title: Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism.
Volume: 11
Issue: 2
Pages: 231-41
Publication
First Author: García-Higuera I
Year: 2008
Journal: Nat Cell Biol
Title: Genomic stability and tumour suppression by the APC/C cofactor Cdh1.
Volume: 10
Issue: 7
Pages: 802-11
Publication
First Author: Wirth KG
Year: 2004
Journal: Genes Dev
Title: Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.
Volume: 18
Issue: 1
Pages: 88-98
Publication
First Author: Lee SB
Year: 2015
Journal: Mol Cell
Title: Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.
Volume: 60
Issue: 1
Pages: 21-34
Publication
First Author: Listovsky T
Year: 2013
Journal: J Cell Biol
Title: Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.
Volume: 203
Issue: 1
Pages: 87-100
Publication
First Author: Mao DD
Year: 2015
Journal: Cell Rep
Title: A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells.
Volume: 11
Issue: 11
Pages: 1809-21
Publication
First Author: Sanz-Gómez N
Year: 2020
Journal: Cell Death Differ
Title: Squamous differentiation requires G2/mitosis slippage to avoid apoptosis.
Volume: 27
Issue: 8
Pages: 2451-2467
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 921  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
Publication
First Author: Zhang Y
Year: 2011
Journal: PLoS One
Title: Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Volume: 6
Issue: 8
Pages: e23389
Publication
First Author: Huang W
Year: 2020
Journal: J Biol Chem
Title: The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity.
Volume: 295
Issue: 18
Pages: 5906-5917
Publication
First Author: Chiremba TT
Year: 2021
Journal: Mol Biol Cell
Title: Constitutive Musashi1 expression impairs mouse postnatal development and intestinal homeostasis.
Volume: 32
Issue: 1
Pages: 28-44
Publication
First Author: Guo L
Year: 2023
Journal: Theranostics
Title: PER2 integrates circadian disruption and pituitary tumorigenesis.
Volume: 13
Issue: 8
Pages: 2657-2672
Publication
First Author: Chen E
Year: 2006
Journal: Oncogene
Title: Dysregulated expression of mitotic regulators is associated with B-cell lymphomagenesis in HOX11-transgenic mice.
Volume: 25
Issue: 18
Pages: 2575-87
Publication
First Author: Sigl R
Year: 2009
Journal: J Cell Sci
Title: Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis.
Volume: 122
Issue: Pt 22
Pages: 4208-17
Publication
First Author: Sironi L
Year: 2002
Journal: EMBO J
Title: Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint.
Volume: 21
Issue: 10
Pages: 2496-506
Publication
First Author: Orth M
Year: 2011
Journal: EMBO J
Title: Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
Volume: 30
Issue: 14
Pages: 2868-80
Publication
First Author: Homer HA
Year: 2005
Journal: Reproduction
Title: Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.
Volume: 130
Issue: 6
Pages: 829-43
Publication
First Author: Jeganathan KB
Year: 2005
Journal: Nature
Title: The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.
Volume: 438
Issue: 7070
Pages: 1036-9
Publication
First Author: Ma HT
Year: 2009
Journal: Mol Cell Biol
Title: Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Volume: 29
Issue: 24
Pages: 6500-14
Publication
First Author: Guo Z
Year: 2021
Journal: Oncogene
Title: The long noncoding RNA CRYBG3 induces aneuploidy by interfering with spindle assembly checkpoint via direct binding with Bub3.
Volume: 40
Issue: 10
Pages: 1821-1835
Publication
First Author: Li R
Year: 1993
Journal: Nature
Title: The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.
Volume: 366
Issue: 6450
Pages: 82-4
Publication
First Author: Yudkovsky Y
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint.
Volume: 271
Issue: 2
Pages: 299-304
Publication
First Author: Okaz E
Year: 2012
Journal: Cell
Title: Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.
Volume: 151
Issue: 3
Pages: 603-18
Publication
First Author: de Boer HR
Year: 2016
Journal: Cell Mol Life Sci
Title: Controlling the response to DNA damage by the APC/C-Cdh1.
Volume: 73
Issue: 5
Pages: 949-60
Publication
First Author: Pesin JA
Year: 2007
Journal: PLoS Genet
Title: Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator.
Volume: 3
Issue: 11
Pages: e202
Protein Domain
Type: Family
Description: The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy []. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest []. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C []. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage []. Protein cortex from Drosophila melanogasterwhich is a female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) required for the completion of meiosis in oocytes, is also included in this entry. Cortex activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis [, ].
Publication
First Author: Stachelscheid J
Year: 2023
Journal: Blood
Title: The proto-oncogene TCL1A deregulates cell cycle and genomic stability in CLL.
Volume: 141
Issue: 12
Pages: 1425-1441
Publication
First Author: Seah MK
Year: 2012
Journal: J Cell Sci
Title: The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development.
Volume: 125
Issue: Pt 24
Pages: 6030-7
Publication
First Author: Komaravolu RK
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury.
Volume: 39
Issue: 10
Pages: 2132-2144
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory