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Search results 301 to 378 out of 378 for Gpnmb

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Type Details Score
Publication
18381073 | J:134263
First Author: Sheng MH
Year: 2008
Journal: FEBS Lett
Title: Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity.
Volume: 582
Issue: 10
Pages: 1451-8
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Publication
29370175 | J:256989
First Author: King R
Year: 2018
Journal: PLoS Genet
Title: Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
Volume: 14
Issue: 1
Pages: e1007145
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Publication
19493314 | J:157352
First Author: Loftus SK
Year: 2009
Journal: Pigment Cell Melanoma Res
Title: Comparison of melanoblast expression patterns identifies distinct classes of genes.
Volume: 22
Issue: 5
Pages: 611-22
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Publication
27418600 | J:235148
First Author: Anderson DM
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
Volume: 113
Issue: 31
Pages: E4494-503
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Publication
30606613 | J:270443
First Author: Li Q
Year: 2019
Journal: Neuron
Title: Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing.
Volume: 101
Issue: 2
Pages: 207-223.e10
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Publication
22056141 | J:177840
First Author: Magri L
Year: 2011
Journal: Cell Stem Cell
Title: Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.
Volume: 9
Issue: 5
Pages: 447-62
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Publication
16332269 | J:156373
First Author: Chang B
Year: 2005
Journal: Vis Neurosci
Title: Mouse models of ocular diseases.
Volume: 22
Issue: 5
Pages: 587-93
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Publication
28973166 | J:253459
First Author: Inoue SI
Year: 2017
Journal: Hum Mol Genet
Title: Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice.
Volume: 26
Issue: 23
Pages: 4715-4727
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Allele
Tg(Fabp4-Gpnmb)1Jwada | MGI:6761839
Name: transgene insertion 1, Jun Wada
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
30149180 | J:268454
 
First Author: Moloney EB
Year: 2018
Journal: Neurobiol Dis
Title: The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.
Volume: 120
Pages: 1-11
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Publication
31043488 | J:277665
First Author: Baba M
Year: 2019
Journal: Mol Cancer Res
Title: TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease.
Volume: 17
Issue: 8
Pages: 1613-1626
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Allele
Gpnmb<em1Smoc> | MGI:7289960
Name: glycoprotein (transmembrane) nmb; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
34207849 | -
 
First Author: Chrystal PW
Year: 2021
Journal: Molecules
Title: Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins.
Volume: 26
Issue: 12
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Strain
MGI:6428756 | C57BL/6J-Gpnmb<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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DO Term
DOID:0080932 | primary localized cutaneous amyloidosis 3
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Publication
26694611 | -
First Author: Ho T
Year: 2016
Journal: J Biol Chem
Title: The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.
Volume: 291
Issue: 7
Pages: 3595-612
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Protein Domain
IPR046846 | PKAT_KLD
Type: Domain
Description: This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and Transmembrane protein 130 (TMEM130), which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers and promotes PMEL functional amyloid formation [, ]. This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family []. PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.
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Protein
Q9QY67
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: true
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Protein
Q9QY70
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
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Protein
Q3UE75
Organism: Mus musculus/domesticus
Length: 274  
Fragment?: true
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Protein
A0A1W2P7B8
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
A0A1W2P7H5
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Protein Domain
IPR045219 | PKAT
Type: Family
Description: This family includes Melanocyte protein PMEL (also known as PMEL-17), Transmembrane glycoprotein NMB (GPNMB) and Transmembrane protein 130, previously described as melanocyte protein PMEL-17-related family. Regarding the highly conserved domain architecture of these family members, including the PKD, KLD and transmembrane (TM) domains, the name was updated and now referred to as PKD- and KLD-Associated Transmembrane (PKAT) protein family []. TMEM130 has been identified as the most ancient paralogue of PMEL and GPNMB.PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.
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Publication
25775479 | J:229633
First Author: Zigdon H
Year: 2015
Journal: PLoS One
Title: Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease.
Volume: 10
Issue: 3
Pages: e0120194
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Publication
23582180 | J:204729
First Author: Swaminathan S
Year: 2013
Journal: Pigment Cell Melanoma Res
Title: Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains.
Volume: 26
Issue: 4
Pages: 487-98
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Protein
Q99P91
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q60696
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q6NXM3
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: false
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Protein
Q3TWC7
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q9CZB2
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q8BVA0
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Q3TAV1
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q3TBB0
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q3TXG7
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Publication
27078017 | J:252394
First Author: Bhattacharyya S
Year: 2016
Journal: PLoS One
Title: Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF.
Volume: 11
Issue: 4
Pages: e0153463
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Publication
28459858 | J:243296
First Author: Wu JW
Year: 2017
Journal: PLoS Genet
Title: Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.
Volume: 13
Issue: 5
Pages: e1006716
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Publication
34735454 | J:319700
First Author: Kingston R
Year: 2021
Journal: PLoS Genet
Title: Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury.
Volume: 17
Issue: 11
Pages: e1009885
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Publication
31806376 | J:294581
First Author: Isono Y
Year: 2020
Journal: Biochem Biophys Res Commun
Title: FLCN alteration drives metabolic reprogramming towards nucleotide synthesis and cyst formation in salivary gland.
Volume: 522
Issue: 4
Pages: 931-938
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Publication
21209915 | J:196261
First Author: Hong SB
Year: 2010
Journal: PLoS One
Title: Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
Volume: 5
Issue: 12
Pages: e15793
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Publication
33577922 | J:307703
 
First Author: Canet-Pons J
Year: 2021
Journal: Neurobiol Dis
Title: Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Volume: 152
Pages: 105289
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Publication
33028409 | J:308483
First Author: Huang M
Year: 2020
Journal: Acta Neuropathol Commun
Title: Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations.
Volume: 8
Issue: 1
Pages: 163
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Publication
36618392 | J:332607
 
First Author: Houser MC
Year: 2022
Journal: Front Immunol
Title: Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
Volume: 13
Pages: 1056417
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom