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Search results 301 to 348 out of 348 for Lcat

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0.024s

Type

Details

Score

Publication

7657816 | J:121992

First Author:	Francone OL
Year:	1995
Journal:	J Clin Invest
Title:	Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism.
Volume:	96
Issue:	3
Pages:	1440-8

•

Strain

MGI:2164466 | C57BL/6-Tg(AlbLCAT)1Jdm/J

Attribute String:

mutant strain, transgenic

•

Allele

Tg(LCAT)A31Ssf | MGI:3696854

Name:	transgene insertion A31, Silvia Santamarina-Fojo
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

Allele

Tg(LCAT)T59Ssf | MGI:3696856

Name:	transgene insertion T59, Silvia Santamarina-Fojo
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

Genotype

Symbol:	Tg(AlbLCAT)1Jdm/? Tg(APOA1)1Rub/?
Background:	involves: C57BL/6 * FVB/N
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(AlbLCAT)1Jdm/?
Background:	involves: FVB/N
Zygosity:	ot
Has Mutant Allele:	true

•

Publication

7744879 | J:118356

First Author:	Vaisman BL
Year:	1995
Journal:	J Biol Chem
Title:	Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice.
Volume:	270
Issue:	20
Pages:	12269-75

•

Strain

MGI:4431389 | C57BL/6N-Tg(LCAT)A31Ssf/Mmmh

Attribute String:

coisogenic, mutant strain, transgenic

•

Strain

MGI:5086110 | C57BL/6N-Tg(LCAT)A31Ssf

Attribute String:

coisogenic, mutant strain, transgenic

•

Strain

MGI:4431390 | C57BL/6N-Tg(LCAT)T59Ssf/Mmmh

Attribute String:

transgenic, mutant strain, coisogenic

•

Strain

MGI:5086109 | C57BL/6N-Tg(LCAT)T59Ssf

Attribute String:

transgenic, mutant stock, coisogenic

•

Genotype

Symbol:	Tg(AlbLCAT)1Jdm/? Tg(APOA2)3Rub/?
Background:	involves: C57BL/6 * FVB/N
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(LCAT)T59Ssf/?
Background:	C57BL/6N-Tg(LCAT)T59Ssf
Zygosity:	ot
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(LCAT)A31Ssf/?
Background:	C57BL/6N-Tg(LCAT)A31Ssf
Zygosity:	ot
Has Mutant Allele:	true

•

Genotype

Symbol:	Tg(LCAT)A31Ssf/Tg(LCAT)A31Ssf
Background:	C57BL/6N-Tg(LCAT)A31Ssf
Zygosity:	hm
Has Mutant Allele:	true

•

Publication

26195816 | -

First Author:	Piper DE
Year:	2015
Journal:	J Lipid Res
Title:	The high-resolution crystal structure of human LCAT.
Volume:	56
Issue:	9
Pages:	1711-9

•

Publication

8326012 | -

First Author:	Klein HG
Year:	1993
Journal:	J Clin Invest
Title:	Fish eye syndrome: a molecular defect in the lecithin-cholesterol acyltransferase (LCAT) gene associated with normal alpha-LCAT-specific activity. Implications for classification and prognosis.
Volume:	92
Issue:	1
Pages:	479-85

•

Publication

25727495 | -

First Author:	Glukhova A
Year:	2015
Journal:	Nat Commun
Title:	Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
Volume:	6

Pages:	6250

•

Protein Domain

IPR003386 | LACT/PDAT_acylTrfase

Type:

Family

Description:

This entry represents a group of lipid metabolizing enzymes, including LACT and LPLA2 from humans, and PDAT from plants.Lecithin:cholesterol acyltransferase (LACT), also known as phosphatidylcholine-sterol acyltransferase (), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Its structure has been revealed []. Defects in LACT cause Fish eye disease and familial LCAT deficiency [].Phospholipid:diacylglycerol acyltransferase (PDAT)() is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid [].Lysosomal phospholipase A2 (LPLA2) () plays important roles for lung surfactant metabolism and maturation of invariant natural killer T cells. Its structure has been revealed [].

•

Genotype

Symbol:	Tg(AlbLCAT)1Jdm/? Tg(APOA1)1Rub/? Tg(APOA2)3Rub/?
Background:	involves: C57BL/6 * FVB/N
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

18992221 | J:143183

First Author:	de Haan W
Year:	2008
Journal:	Biochem Biophys Res Commun
Title:	Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo.
Volume:	377
Issue:	4
Pages:	1294-8

•

Publication

35235775 | J:339137

First Author:	Lu K
Year:	2022
Journal:	Cell Metab
Title:	Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression.
Volume:	34
Issue:	3
Pages:	441-457.e7

•

Publication

22566575 | J:187463

First Author:	Kunnen S
Year:	2012
Journal:	J Lipid Res
Title:	Lecithin:cholesterol acyltransferase: old friend or foe in atherosclerosis?
Volume:	53
Issue:	9
Pages:	1783-99

•

Protein

P16301

Organism:	Mus musculus/domesticus
Length:	438
Fragment?:	false

•

Protein

Q8VEB4

Organism:	Mus musculus/domesticus
Length:	412
Fragment?:	false

•

Protein

Q9CW47

Organism:	Mus musculus/domesticus
Length:	444
Fragment?:	true

•

Protein

A0A1D5RLZ5

Organism:	Mus musculus/domesticus
Length:	236
Fragment?:	false

•

Publication

12963726 | -

First Author:	Zhang Q
Year:	2003
Journal:	J Biol Chem
Title:	Schizosaccharomyces pombe cells deficient in triacylglycerols synthesis undergo apoptosis upon entry into the stationary phase.
Volume:	278
Issue:	47
Pages:	47145-55

•

Publication

16931800 | J:125063

First Author:	Liao D
Year:	2006
Journal:	Circ Res
Title:	Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance.
Volume:	99
Issue:	6
Pages:	598-606

•

Publication

17206937 | J:121679

First Author:	Kypreos KE
Year:	2007
Journal:	Biochem J
Title:	Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
Volume:	403
Issue:	2
Pages:	359-67

•

Publication

17438339 | J:122492

First Author:	Qu S
Year:	2007
Journal:	J Lipid Res
Title:	Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice.
Volume:	48
Issue:	7
Pages:	1476-87

•

Publication

17960026 | J:130277

First Author:	Yvan-Charvet L
Year:	2008
Journal:	J Lipid Res
Title:	SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL.
Volume:	49
Issue:	1
Pages:	107-14

•

Publication

8808761 | J:111816

First Author:	Francone OL
Year:	1996
Journal:	J Lipid Res
Title:	Increased prebeta-HDL levels, cholesterol efflux, and LCAT-mediated esterification in mice expressing the human cholesteryl ester transfer protein (CETP) and human apolipoprotein A-I (apoA-I) transgenes.
Volume:	37
Issue:	6
Pages:	1268-77

•

Publication

10766851 | J:61733

First Author:	Sorci-Thomas MG
Year:	2000
Journal:	J Biol Chem
Title:	Single repeat deletion in ApoA-I blocks cholesterol esterification and results in rapid catabolism of delta6 and wild-type ApoA-I in transgenic mice.
Volume:	275
Issue:	16
Pages:	12156-63

•

Publication

16497661 | J:109005

First Author:	Mezdour H
Year:	2006
Journal:	J Lipid Res
Title:	Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency.
Volume:	47
Issue:	5
Pages:	912-20

•

Publication

11798161 | J:74770

First Author:	Oda MN
Year:	2002
Journal:	Biochem Biophys Res Commun
Title:	Paraoxonase 1 overexpression in mice and its effect on high-density lipoproteins.
Volume:	290
Issue:	3
Pages:	921-7

•

Publication

7947997 | J:21597

First Author:	Subbaiah PV
Year:	1994
Journal:	Biochim Biophys Acta
Title:	Substrate and positional specificities of human and mouse lecithin-cholesterol acyltransferases. Studies with wild type recombinant and chimeric enzymes expressed in vitro.
Volume:	1215
Issue:	1-2
Pages:	150-6

•

Publication

8995259 | J:37651

First Author:	Wang J
Year:	1997
Journal:	J Biol Chem
Title:	Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.
Volume:	272
Issue:	1
Pages:	280-6

•

Publication

9197549 | J:40828

First Author:	Miller M
Year:	1997
Journal:	Gene
Title:	Alternative splicing in lecithin:cholesterol acyltransferase mRNA: an evolutionary paradigm in humans and great apes.
Volume:	190
Issue:	2
Pages:	309-13

•

Publication

9254920 | J:41962

First Author:	Robinson M
Year:	1997
Journal:	Mol Biol Evol
Title:	Evolution of isochores in rodents.
Volume:	14
Issue:	8
Pages:	823-8

•

Publication

10669644 | J:130702

First Author:	Holvoet P
Year:	2000
Journal:	Arterioscler Thromb Vasc Biol
Title:	The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice.
Volume:	20
Issue:	2
Pages:	459-66

•

Publication

28611100 | J:245828

First Author:	Ma A
Year:	2017
Journal:	J Lipid Res
Title:	AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE^-/- mice.
Volume:	58
Issue:	8
Pages:	1536-1547

•

Publication

7607230 | J:277281

First Author:	Mehlum A
Year:	1995
Journal:	Eur J Biochem
Title:	Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile.
Volume:	230
Issue:	2
Pages:	567-75

•

Publication

34973414 | J:319851

First Author:	Thymiakou E
Year:	2022
Journal:	Biochim Biophys Acta Mol Cell Biol Lipids
Title:	Intestine-specific ablation of the Hepatocyte Nuclear Factor 4a (Hnf4a) gene in mice has minimal impact on serum lipids and ileum gene expression profile due to upregulation of its paralog Hnf4g.
Volume:	1867
Issue:	3
Pages:	159108

•

Publication

11108726 | J:66421

First Author:	Mehrabian M
Year:	2000
Journal:	J Lipid Res
Title:	Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J).
Volume:	41
Issue:	12
Pages:	1936-46

•

Publication

12859204 | J:84572

First Author:	Francone OL
Year:	2003
Journal:	Biochemistry
Title:	Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1.
Volume:	42
Issue:	28
Pages:	8569-78

•

Publication

9186920 | J:40819

First Author:	Plump AS
Year:	1997
Journal:	J Lipid Res
Title:	ApoA-I knockout mice: characterization of HDL metabolism in homozygotes and identification of a post-RNA mechanism of apoA-I up-regulation in heterozygotes.
Volume:	38
Issue:	5
Pages:	1033-47

•

Publication

8636092 | J:129465

First Author:	Marzal-Casacuberta A
Year:	1996
Journal:	J Biol Chem
Title:	Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II.
Volume:	271
Issue:	12
Pages:	6720-8

•

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