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Search results 301 to 400 out of 407 for Trpc3

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Type Details Score
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
29066740 | J:255399
First Author: Dong P
Year: 2017
Journal: Sci Rep
Title: TRPC3 Is Dispensable for β-Alanine Triggered Acute Itch.
Volume: 7
Issue: 1
Pages: 13869
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Publication
34570999 | J:331227
First Author: Beattie K
Year: 2022
Journal: J Invest Dermatol
Title: TRPC3 Antagonizes Pruritus in a Mouse Contact Dermatitis Model.
Volume: 142
Issue: 4
Pages: 1136-1144
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Publication
26554024 | J:237671
First Author: Numaga-Tomita T
Year: 2016
Journal: Biochem J
Title: TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation.
Volume: 473
Issue: 2
Pages: 201-10
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Publication
29438802 | J:262433
 
First Author: Turunen PM
Year: 2018
Journal: Neuroscience
Title: Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels.
Volume: 375
Pages: 135-148
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Publication
25870279 | J:221111
First Author: Smedlund KB
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel.
Volume: 112
Issue: 17
Pages: E2201-6
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HT Experiment
E-MTAB-3517 | The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
9930701 | -
First Author: Hofmann T
Year: 1999
Journal: Nature
Title: Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
Volume: 397
Issue: 6716
Pages: 259-63
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DO Term
DOID:0111744 | cerebellar ataxia type 41
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Protein
Q9QZC1
Organism: Mus musculus/domesticus
Length: 836  
Fragment?: false
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Publication
32037396 | -
First Author: Hu Y
Year: 2020
Journal: Hypertens Res
Title: High-salt intake increases TRPC3 expression and enhances TRPC3-mediated calcium influx and systolic blood pressure in hypertensive patients.
Volume: 43
Issue: 7
Pages: 679-687
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Strain
MGI:5516505 | FVB-Tg(ACTA1*-TRPC3)1Jmol/J
Attribute String: coisogenic, mutant strain, transgenic
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Publication
16055711 | J:106082
First Author: Dietrich A
Year: 2005
Journal: Mol Cell Biol
Title: Increased vascular smooth muscle contractility in TRPC6-/- mice.
Volume: 25
Issue: 16
Pages: 6980-9
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Publication
31099508 | J:289230
First Author: Kong W
Year: 2019
Journal: Cell Physiol Biochem
Title: Renal Fibrosis, Immune Cell Infiltration and Changes of TRPC Channel Expression after Unilateral Ureteral Obstruction in Trpc6-/- Mice.
Volume: 52
Issue: 6
Pages: 1484-1502
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Publication
29187535 | J:256511
First Author: Chung HS
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy.
Volume: 114
Issue: 50
Pages: E10763-E10771
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Publication
36099033 | J:331540
 
First Author: Lin BL
Year: 2022
Journal: JCI Insight
Title: Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy.
Volume: 7
Issue: 19
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Publication
22337127 | J:220927
 
First Author: Weissmann N
Year: 2012
Journal: Nat Commun
Title: Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.
Volume: 3
Pages: 649
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Publication
29373286 | J:281817
 
First Author: Sachdeva R
Year: 2018
Journal: Mol Metab
Title: TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.
Volume: 9
Pages: 156-167
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Publication
30665571 | J:294145
First Author: Wang L
Year: 2019
Journal: Kidney Int
Title: Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice.
Volume: 95
Issue: 2
Pages: 321-332
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Publication
23212367 | J:221241
 
First Author: Xie J
Year: 2012
Journal: Nat Commun
Title: Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
Volume: 3
Pages: 1238
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Publication
18725458 | J:146045
First Author: Keserü B
Year: 2008
Journal: FASEB J
Title: Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.
Volume: 22
Issue: 12
Pages: 4306-15
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Publication
23814119 | J:264473
First Author: Chen W
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Atrial natriuretic peptide-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
Volume: 33
Issue: 9
Pages: 2121-9
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Publication
39375537 | J:360763
First Author: Bröker-Lai J
Year: 2024
Journal: EMBO J
Title: TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.
Volume: 43
Issue: 23
Pages: 5813-5836
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Publication
32322252 | J:321358
 
First Author: Tsvilovskyy V
Year: 2020
Journal: Front Immunol
Title: Analysis of Mrgprb2 Receptor-Evoked Ca 2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice.
Volume: 11
Pages: 564
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Publication
32931478 | J:303087
 
First Author: Weber J
Year: 2020
Journal: JCI Insight
Title: TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema.
Volume: 5
Issue: 20
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Allele
Trpc6<tm1Lbi> | MGI:3623135
Name: transient receptor potential cation channel, subfamily C, member 6; targeted mutation 1, Lutz Birnbaumer
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:5560206 | B6;129S-Trpc6<tm1Lbi>/Mmjax
Attribute String: mutant stock, targeted mutation
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Publication
33135341 | J:352671
First Author: He C
Year: 2020
Journal: Clin Transl Med
Title: Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes.
Volume: 10
Issue: 6
Pages: e205
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Publication
17142322 | J:118269
First Author: Weissmann N
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange.
Volume: 103
Issue: 50
Pages: 19093-8
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Publication
26858457 | J:230418
First Author: Chaudhuri P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation.
Volume: 113
Issue: 8
Pages: 2110-5
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Publication
28835433 | J:248140
First Author: Chaudhuri P
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization.
Volume: 313
Issue: 5
Pages: C541-C555
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Publication
36460692 | J:334628
First Author: Tang N
Year: 2022
Journal: Nat Commun
Title: TRPC channels blockade abolishes endotoxemic cardiac dysfunction by hampering intracellular inflammation and Ca(2+) leakage.
Volume: 13
Issue: 1
Pages: 7455
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Publication
35396331 | J:353005
First Author: Caval-Holme FS
Year: 2022
Journal: J Neurosci
Title: The Retinal Basis of Light Aversion in Neonatal Mice.
Volume: 42
Issue: 20
Pages: 4101-4115
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Publication
22206677 | J:180287
First Author: Paez Espinosa EV
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Mouse transient receptor potential channel 6: role in hemostasis and thrombogenesis.
Volume: 417
Issue: 2
Pages: 853-6
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Publication
36940798 | J:349842
First Author: May CJ
Year: 2023
Journal: Kidney Int
Title: Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.
Volume: 104
Issue: 2
Pages: 265-278
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Publication
38528525 | J:346625
First Author: Abcouwer SF
Year: 2024
Journal: J Neuroinflammation
Title: The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment.
Volume: 21
Issue: 1
Pages: 74
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Publication
35749414 | J:334958
First Author: Boekell KL
Year: 2022
Journal: PLoS One
Title: Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets.
Volume: 17
Issue: 6
Pages: e0270431
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Publication
35537100 | J:325671
First Author: Wang Z
Year: 2022
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction.
Volume: 323
Issue: 1
Pages: R81-R97
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Publication
26392222 | J:229037
First Author: Weber EW
Year: 2015
Journal: J Exp Med
Title: TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response.
Volume: 212
Issue: 11
Pages: 1883-99
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Publication
31162976 | J:294014
First Author: Numaga-Tomita T
Year: 2019
Journal: FASEB J
Title: TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Volume: 33
Issue: 9
Pages: 9785-9796
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Publication
28646178 | J:271483
First Author: Li W
Year: 2017
Journal: Sci Rep
Title: Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice.
Volume: 7
Issue: 1
Pages: 4145
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Publication
30779919 | J:277912
First Author: Chen QZ
Year: 2019
Journal: Exp Cell Res
Title: TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF-κB activation and ICAM-1 expression with ozone exposure.
Volume: 377
Issue: 1-2
Pages: 56-66
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Publication
25844902 | J:222410
First Author: Wang L
Year: 2015
Journal: J Clin Invest
Title: Gq signaling causes glomerular injury by activating TRPC6.
Volume: 125
Issue: 5
Pages: 1913-26
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Publication
32412783 | J:298157
First Author: Nemeth Z
Year: 2020
Journal: Am J Physiol Heart Circ Physiol
Title: Pressure-induced constriction of the middle cerebral artery is abolished in TrpC6 knockout mice.
Volume: 319
Issue: 1
Pages: H42-H50
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Publication
21768109 | J:176613
First Author: Ding Y
Year: 2011
Journal: J Biol Chem
Title: Reactive oxygen species-mediated TRPC6 protein activation in vascular myocytes, a mechanism for vasoconstrictor-regulated vascular tone.
Volume: 286
Issue: 36
Pages: 31799-809
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Publication
34866402 | J:345068
First Author: Wang Z
Year: 2022
Journal: Am J Physiol Renal Physiol
Title: Transient receptor potential cation channel 6 contributes to kidney injury induced by diabetes and hypertension.
Volume: 322
Issue: 1
Pages: F76-F88
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Publication
34230483 | J:313723
First Author: Torres-Torrelo H
Year: 2021
Journal: Nat Commun
Title: Lactate sensing mechanisms in arterial chemoreceptor cells.
Volume: 12
Issue: 1
Pages: 4166
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Publication
23489970 | J:316060
First Author: Medic N
Year: 2013
Journal: Cell Calcium
Title: Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production.
Volume: 53
Issue: 5-6
Pages: 315-26
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Publication
36224261 | J:350158
First Author: El Hamdaoui Y
Year: 2022
Journal: Mol Psychiatry
Title: Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
Volume: 27
Issue: 12
Pages: 5070-5085
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Publication
39625977 | J:360700
First Author: Matsushita Y
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain.
Volume: 121
Issue: 50
Pages: e2404877121
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Publication
32321939 | J:298507
First Author: Bendiks L
Year: 2020
Journal: Sci Rep
Title: Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
Volume: 10
Issue: 1
Pages: 6812
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Publication
23636057 | J:204765
First Author: Lindemann O
Year: 2013
Journal: J Immunol
Title: TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils.
Volume: 190
Issue: 11
Pages: 5496-505
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Publication
30873821 | J:291784
First Author: Hasna J
Year: 2019
Journal: Cell Physiol Biochem
Title: The Deletion of TRPC6 Channels Perturbs Iron and Zinc Homeostasis and Pregnancy Outcome in Mice.
Volume: 52
Issue: 3
Pages: 455-467
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Publication
27932059 | J:254041
First Author: Hofmann K
Year: 2017
Journal: Biochim Biophys Acta
Title: Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.
Volume: 1863
Issue: 2
Pages: 560-568
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Publication
29793963 | J:290103
First Author: Ilatovskaya DV
Year: 2018
Journal: J Am Soc Nephrol
Title: A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.
Volume: 29
Issue: 7
Pages: 1917-1927
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Publication
23022034 | J:189077
First Author: Davis J
Year: 2012
Journal: Dev Cell
Title: A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo.
Volume: 23
Issue: 4
Pages: 705-15
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Publication
24144647 | J:281915
First Author: Xia Y
Year: 2014
Journal: Hypertension
Title: Classical transient receptor potential 1 and 6 contribute to hypoxic pulmonary hypertension through differential regulation of pulmonary vascular functions.
Volume: 63
Issue: 1
Pages: 173-80
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Publication
24520961 | J:330461
First Author: Chen W
Year: 2014
Journal: J Thromb Haemost
Title: Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets.
Volume: 12
Issue: 4
Pages: 528-39
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Publication
35194063 | J:322550
First Author: Zheng Z
Year: 2022
Journal: Sci Rep
Title: Role of TRPC6 in kidney damage after acute ischemic kidney injury.
Volume: 12
Issue: 1
Pages: 3038
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Publication
22176814 | J:330460
First Author: Ramanathan G
Year: 2012
Journal: J Thromb Haemost
Title: Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets.
Volume: 10
Issue: 3
Pages: 419-29
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Genotype
Genotype
Symbol: Trpc6/Trpc6
Background: involves: 129S/SvEv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trpc1/Trpc1 Trpc4/Trpc4 Trpc6/Trpc6
Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Trpc6/Trpc6
Background: involves: 129S/SvEv
Zygosity: hm
Has Mutant Allele: true
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Publication
19864620 | J:154908
First Author: Millay DP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism.
Volume: 106
Issue: 45
Pages: 19023-8
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Publication
34764278 | J:322041
First Author: Kim JH
Year: 2021
Journal: Nat Commun
Title: Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria.
Volume: 12
Issue: 1
Pages: 6537
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Publication
31961827 | J:297228
First Author: Ortiz-Muñoz G
Year: 2020
Journal: J Clin Invest
Title: Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.
Volume: 130
Issue: 4
Pages: 2041-2053
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Publication
24838176 | J:247236
First Author: Schleifenbaum J
Year: 2014
Journal: Circ Res
Title: Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.
Volume: 115
Issue: 2
Pages: 263-72
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Publication
26604306 | J:228125
First Author: Riazanski V
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Volume: 112
Issue: 47
Pages: E6486-95
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Publication
23027959 | J:190298
First Author: Li W
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice.
Volume: 109
Issue: 42
Pages: 17087-92
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Publication
24811382 | J:214102
First Author: Hartmann J
Year: 2014
Journal: Neuron
Title: STIM1 controls neuronal Ca²⁺ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior.
Volume: 82
Issue: 3
Pages: 635-44
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Publication
26464974 | J:229610
 
First Author: Sinai L
Year: 2015
Journal: eNeuro
Title: Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I(1,2).
Volume: 2
Issue: 2
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Publication
19277847 | J:219187
First Author: Woo JS
Year: 2009
Journal: Mol Cell Biochem
Title: Glutamate at position 227 of junctophilin-2 is involved in binding to TRPC3.
Volume: 328
Issue: 1-2
Pages: 25-32
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Publication
20932311 | J:166067
 
First Author: Sciarretta C
Year: 2010
Journal: BMC Dev Biol
Title: PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.
Volume: 10
Pages: 103
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Publication
33839150 | J:306699
   
First Author: Takatani T
Year: 2021
Journal: J Biol Chem
Title: Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.
Pages: 100646
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Publication
33707208 | J:303806
 
First Author: Peavey MC
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility.
Volume: 118
Issue: 11
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Publication
22207724 | J:317565
First Author: Kusudo T
Year: 2012
Journal: J Appl Physiol (1985)
Title: TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity.
Volume: 112
Issue: 7
Pages: 1223-32
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Publication
26963818 | J:253532
First Author: Grandclément C
Year: 2016
Journal: PLoS One
Title: NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels.
Volume: 11
Issue: 3
Pages: e0151031
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Publication
39384900 | J:359150
First Author: Zernov N
Year: 2024
Journal: Sci Rep
Title: Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer's disease hippocampal neurons.
Volume: 14
Issue: 1
Pages: 23512
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Publication
29628897 | J:275884
 
First Author: López E
Year: 2018
Journal: Front Physiol
Title: Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets.
Volume: 9
Pages: 266
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Publication
30789900 | J:273414
First Author: Picardo MCD
Year: 2019
Journal: PLoS Biol
Title: Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.
Volume: 17
Issue: 2
Pages: e2006094
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Publication
23159934 | J:196987
First Author: Eltit JM
Year: 2013
Journal: FASEB J
Title: Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia.
Volume: 27
Issue: 3
Pages: 991-1000
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Publication
26239116 | J:231354
First Author: Lopez E
Year: 2015
Journal: Biochim Biophys Acta
Title: FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6.
Volume: 1853
Issue: 10 Pt A
Pages: 2684-96
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Publication
26494622 | J:327475
First Author: Sabourin J
Year: 2015
Journal: J Biol Chem
Title: Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.
Volume: 290
Issue: 51
Pages: 30530-9
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Publication
16407161 | J:248210
First Author: Kawasaki BT
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.
Volume: 103
Issue: 2
Pages: 335-40
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Publication
17360584 | J:248261
First Author: Liao Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Orai proteins interact with TRPC channels and confer responsiveness to store depletion.
Volume: 104
Issue: 11
Pages: 4682-7
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Publication
21670282 | J:245294
First Author: Park HW
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Serine-threonine kinase with-no-lysine 4 (WNK4) controls blood pressure via transient receptor potential canonical 3 (TRPC3) in the vasculature.
Volume: 108
Issue: 26
Pages: 10750-5
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Publication
29960052 | J:266063
 
First Author: Shimizu N
Year: 2018
Journal: Neurosci Lett
Title: Effects of nerve growth factor neutralization on TRP channel expression in laser-captured bladder afferent neurons in mice with spinal cord injury.
Volume: 683
Pages: 100-103
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Publication
35096991 | J:319713
 
First Author: Norton N
Year: 2021
Journal: Front Cardiovasc Med
Title: Trpc6 Promotes Doxorubicin-Induced Cardiomyopathy in Male Mice With Pleiotropic Differences Between Males and Females.
Volume: 8
Pages: 757784
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Publication
20095964 | -
First Author: Woo JS
Year: 2010
Journal: Biochem J
Title: S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle.
Volume: 427
Issue: 1
Pages: 125-34
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Protein Domain
IPR005459 | TRPC3_channel
Type: Family
Description: Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The classical or canonical TRPC family (formerly short-TRPs, STRPs) encompasses channels presenting a large number of different activation modes. Some are store-operated, whereas others are receptor-operated channels activated by the production of diacylglicerol or redox processes. TRPC proteins also control growth cone guidance in both mammalian and amphibian model systems. All seven channels of this family share the common property of activation through phospholipase C (PLC)-coupled receptors []. It is believed that functional TRPC channels are generated in situ by association of four TRPC proteins to form either homotetramers or heterotetramers [].On the basis of sequence similarity, TRPC channels can be subdivided into four subgroups group 1 (TRPC1), group 2 (TRPC2), group 3 (TRPC3, TRPC6 and TRPC7) and group 4 (TRPC4 and TRPC5) []. While TRPC1 and TRPC2 are almost unique, TRPC4 and TRPC5 share approx. 65% identity. TRPC3, 6 and 7 form a structural and functional subfamily sharing 70-80% identity at the amino acid level and their common sensitivity towards diacylglycerol (DAG).TRPC3, 6, and 7 interact physically and, upon coexpression, coassemble to form functional tetrameric channels [].TRPC3 is likely to be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 [, ]. High levels of TRPC3 mRNA have been related to elevated salt intake and increased blood pressure [].
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Publication
32153426 | J:312222
 
First Author: Lopez JR
Year: 2020
Journal: Front Physiol
Title: Contribution of TRPC Channels to Intracellular Ca2 + Dyshomeostasis in Smooth Muscle From mdx Mice.
Volume: 11
Pages: 126
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Publication
36398712 | J:350528
First Author: Hahn S
Year: 2023
Journal: J Physiol
Title: Proximal dendritic localization of NALCN channels underlies tonic and burst firing in nigral dopaminergic neurons.
Volume: 601
Issue: 1
Pages: 171-193
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Publication
29871977 | J:280003
First Author: Zhang Y
Year: 2018
Journal: Circulation
Title: Multiprotein Complex With TRPC (Transient Receptor Potential-Canonical) Channel, PDE1C (Phosphodiesterase 1C), and A2R (Adenosine A2 Receptor) Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival.
Volume: 138
Issue: 18
Pages: 1988-2002
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Protein
Q32MT5
Organism: Mus musculus/domesticus
Length: 836  
Fragment?: false
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Protein
E6Y6Q0
Organism: Mus musculus/domesticus
Length: 808  
Fragment?: false
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Protein
Q8CCQ1
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
Q8BNT8
Organism: Mus musculus/domesticus
Length: 836  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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