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Search results 3401 to 3473 out of 3473 for Ptch1

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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GXD Expression
GXD Expression
Probe: MGI:7256457
Assay Type: RNA in situ
Annotation Date: 2022-03-23
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3594419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7256489
Age: embryonic day 11.5
Image: 4F
Note: Decreased expression upon loss of Ptch1 and Ptch2.
Specimen Label: 4F
Detected: true
Specimen Num: 5
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DO Term
DOID:0110876 | holoprosencephaly 7
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GXD Expression
GXD Expression
Probe: MGI:6382995
Assay Type: RNA in situ
Annotation Date: 2020-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716823
Pattern: Widespread
Stage: TS23
Assay Id: MGI:6383014
Age: embryonic day 15.5
Image: 2G
Note: Authors report expression comparable to that of Gli1 and Ptch1 in wild type retina.
Specimen Label: 2G
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7256459
Assay Type: RNA in situ
Annotation Date: 2022-03-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:7256491
Age: embryonic day 11.5
Image: 4I
Note: Ectopic expression in anterior of limb further exacerbated upon loss of both Ptch1 and Ptch2.
Specimen Label: 4I
Detected: true
Specimen Num: 3
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DO Term
DOID:0070365 | nevoid basal cell carcinoma syndrome 1
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GXD Expression
GXD Expression
Probe: MGI:6711085
Assay Type: RNA in situ
Annotation Date: 2021-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276320
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:6711092
Age: embryonic day 12.5
Image: 3L
Note: Expression was detected in the region of the vibrissae in a ring outside of the Ptch1 expression domain.
Specimen Label: 3L
Detected: true
Specimen Num: 2
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Publication
30670636 | J:281873
 
First Author: Dobson THW
Year: 2019
Journal: Sci Signal
Title: Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma.
Volume: 12
Issue: 565
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Allele
Ptch1<tm1Smoc> | MGI:7291869
Name: patched 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Tg(Mt1-Ptch1)MT22Mps | MGI:3617013
Name: transgene insertion MT22, Matthew P Scott
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6355137 | C57BL/6J-Ptch1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Allele
Tg(Mt1-Ptch1)MT19Mps | MGI:3617012
Name: transgene insertion MT19, Matthew P Scott
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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HT Experiment
GSE205921 | RNA sequencing of E13.5 mouse Foxd1Cre;Ptch1(flox/-) whole kidneys
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Tg(KRT14-Ptch1)#Abal | MGI:4830587
Name: transgene insertion, Allan Balmain
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Ptch1/Ptch1 Tg(Mt1-Ptch1)MT22Mps/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
GSE183470 | Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c [I]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Hhip/Hhip<+> Ptch1/Ptch1 Tg(Mt1-Ptch1)MT22Mps/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hhip/Hhip Ptch1/Ptch1 Tg(Mt1-Ptch1)MT22Mps/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB
Zygosity: cx
Has Mutant Allele: true
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Publication
16024801 | J:100018
First Author: Campaner S
Year: 2005
Journal: Mol Cell Biol
Title: Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.
Volume: 25
Issue: 15
Pages: 6660-72
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Publication
8825637 | J:30580
First Author: Collazo-Garcia N
Year: 1995
Journal: Genomics
Title: Cloning and characterization of a murine SIL gene.
Volume: 30
Issue: 3
Pages: 506-13
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Protein
Q60988
Organism: Mus musculus/domesticus
Length: 1262  
Fragment?: false
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Protein
A2AD39
Organism: Mus musculus/domesticus
Length: 1262  
Fragment?: false
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Protein
F6VXM5
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
D6RH61
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
B2RUI9
Organism: Mus musculus/domesticus
Length: 1262  
Fragment?: false
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Protein
B7ZNX3
Organism: Mus musculus/domesticus
Length: 1261  
Fragment?: false
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Protein
Q8BQI9
Organism: Mus musculus/domesticus
Length: 641  
Fragment?: true
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Protein
A0A1B0GXH2
Organism: Mus musculus/domesticus
Length: 640  
Fragment?: true
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Publication
17576815 | J:320164
First Author: Pfaff KL
Year: 2007
Journal: Mol Cell Biol
Title: The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.
Volume: 27
Issue: 16
Pages: 5887-97
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Publication
19215732 | -
First Author: Kumar A
Year: 2009
Journal: Am J Hum Genet
Title: Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly.
Volume: 84
Issue: 2
Pages: 286-90
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Protein Domain
IPR026123 | Sil
Type: Family
Description: SIL (also called STIL/TAL1 interrupting locus) is an immediate-early gene that is essential for embryonic development and is implicated in T-cell leukemia-associated translocations [, ]. Sil protein is necessary for proper mitotic spindle organisation in zebrafish and human cells and localizes to the mitotic spindle poles only during metaphase []. Mouse Sil was suggested to play a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 []. In human, cell cycle-dependent phosphorylation of Sil is required for its interaction with Pin1, a regulator of mitosis [].Primary microcephaly (MCPH) is an autosomal-recessive congenital disorder characterised by smaller-than-normal brain size and mental retardation. Three different homozygous mutations in SIL were identified in patients from three of the five families linked to the MCPH7 locus; all are predicted to truncate the Sil protein [].
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HT Experiment
E-GEOD-14470 | MicroRNA profiling in mouse medulloblastomas and normal cerebellar tissues
Series Id: GSE14470
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE169395 | Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and EedcKO Forebrain Transcriptomes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
12006978 | -
First Author: Golling G
Year: 2002
Journal: Nat Genet
Title: Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.
Volume: 31
Issue: 2
Pages: 135-40
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Publication
23780909 | J:200009
First Author: Hettmer S
Year: 2013
Journal: J Pathol
Title: Mutations in Hedgehog pathway genes in fetal rhabdomyomas.
Volume: 231
Issue: 1
Pages: 44-52
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Publication
34326333 | J:308909
First Author: Sun J
Year: 2021
Journal: Nat Commun
Title: SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts.
Volume: 12
Issue: 1
Pages: 4611
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Publication
11130178 | J:66500
First Author: Toftgård R
Year: 2000
Journal: Cell Mol Life Sci
Title: Hedgehog signalling in cancer.
Volume: 57
Issue: 12
Pages: 1720-31
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Publication
31527798 | J:313184
First Author: Wang M
Year: 2020
Journal: Cell Death Differ
Title: Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling.
Volume: 27
Issue: 4
Pages: 1286-1299
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Publication
34161574 | J:338992
 
First Author: Lv B
Year: 2021
Journal: J Cell Biol
Title: E3 ubiquitin ligase Wwp1 regulates ciliary dynamics of the Hedgehog receptor Smoothened.
Volume: 220
Issue: 9
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Publication
35899529 | J:344145
 
First Author: Lv B
Year: 2022
Journal: J Cell Sci
Title: Arih2 regulates Hedgehog signaling through smoothened ubiquitylation and ER-associated degradation.
Volume: 135
Issue: 16
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Publication
25092867 | J:224341
First Author: Chen XL
Year: 2014
Journal: Mol Cell Biol
Title: Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog.
Volume: 34
Issue: 20
Pages: 3855-66
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Publication
29688404 | J:262948
First Author: Yin Y
Year: 2018
Journal: Endocrinology
Title: Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation.
Volume: 159
Issue: 6
Pages: 2459-2472
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Publication
36265686 | J:330830
 
First Author: Echevarría-Andino ML
Year: 2022
Journal: Dev Biol
Title: CDON contributes to Hedgehog-dependent patterning and growth of the developing limb.
Volume: 493
Pages: 1-11
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Publication
33063110 | J:339285
First Author: Hollier PL
Year: 2021
Journal: Cardiovasc Res
Title: Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.
Volume: 117
Issue: 12
Pages: 2489-2501
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Publication
27815386 | J:237990
First Author: Zhu G
Year: 2017
Journal: Cancer Res
Title: PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation.
Volume: 77
Issue: 1
Pages: 123-133
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Publication
23580576 | J:197039
First Author: Gurung B
Year: 2013
Journal: Cancer Res
Title: Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.
Volume: 73
Issue: 8
Pages: 2650-8
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Publication
24347536 | J:237467
First Author: Baht GS
Year: 2014
Journal: J Orthop Res
Title: Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation.
Volume: 32
Issue: 4
Pages: 581-6
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Publication
19372202 | J:158159
First Author: Simon L
Year: 2009
Journal: Endocrinology
Title: Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma.
Volume: 150
Issue: 8
Pages: 3871-6
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Publication
21802063 | J:189277
First Author: Bae GU
Year: 2011
Journal: Am J Hum Genet
Title: Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.
Volume: 89
Issue: 2
Pages: 231-40
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Publication
28445929 | J:264898
First Author: Lau CI
Year: 2017
Journal: Oncotarget
Title: The kinesin motor protein Kif7 is required for T-cell development and normal MHC expression on thymic epithelial cells (TEC) in the thymus.
Volume: 8
Issue: 15
Pages: 24163-24176
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Publication
32114096 | J:291087
 
First Author: Yamada Y
Year: 2020
Journal: Neuroscience
Title: Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.
Volume: 432
Pages: 229-239
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Publication
22622662 | J:288331
First Author: Yasuda T
Year: 2012
Journal: J Dent Res
Title: Muenke syndrome mutation, FgfR3P²⁴⁴R, causes TMJ defects.
Volume: 91
Issue: 7
Pages: 683-9
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Publication
16936257 | J:112359
First Author: Grachtchouk M
Year: 2006
Journal: Am J Pathol
Title: Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans.
Volume: 169
Issue: 3
Pages: 806-14
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Publication
32053600 | J:286041
First Author: Liu P
Year: 2020
Journal: PLoS Biol
Title: NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
Volume: 18
Issue: 2
Pages: e3000620
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Publication
28426816 | J:245904
First Author: Rudigier LJ
Year: 2017
Journal: PLoS One
Title: Ex vivo cultures combined with vivo-morpholino induced gene knockdown provide a system to assess the role of WT1 and GATA4 during gonad differentiation.
Volume: 12
Issue: 4
Pages: e0176296
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Publication
37445982 | J:337955
 
First Author: Toejing P
Year: 2023
Journal: Int J Mol Sci
Title: Accelerated Bone Loss in Transgenic Mice Expressing Constitutively Active TGF-β Receptor Type I.
Volume: 24
Issue: 13
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Publication
31747713 | J:293618
First Author: Yu S
Year: 2020
Journal: Cell Prolif
Title: Circadian BMAL1 regulates mandibular condyle development by hedgehog pathway.
Volume: 53
Issue: 1
Pages: e12727
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Publication
27793670 | J:240898
First Author: Lee H
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Ciliary smoothened-mediated noncanonical hedgehog signaling promotes tubulin acetylation.
Volume: 480
Issue: 4
Pages: 574-579
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Publication
10725363 | J:61194
First Author: Nilsson M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1.
Volume: 97
Issue: 7
Pages: 3438-43
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Publication
12917489 | J:85704
 
First Author: Niemann C
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis.
Volume: 100 Suppl 1
Pages: 11873-80
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Publication
15492281 | J:93644
First Author: Athar M
Year: 2004
Journal: Cancer Res
Title: Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis.
Volume: 64
Issue: 20
Pages: 7545-52
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Publication
24498290 | J:212851
First Author: Meng Q
Year: 2014
Journal: PLoS One
Title: Expression of signaling components in embryonic eyelid epithelium.
Volume: 9
Issue: 2
Pages: e87038
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Publication
22912493 | J:226743
First Author: Bijlsma MF
Year: 2012
Journal: Sci Signal
Title: Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.
Volume: 5
Issue: 238
Pages: ra60
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Publication
31948942 | J:287290
First Author: Wijaya J
Year: 2020
Journal: Cancer Res
Title: An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
Volume: 80
Issue: 7
Pages: 1524-1537
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Publication
25552369 | J:316986
First Author: Dhanyamraju PK
Year: 2015
Journal: Mol Cancer Ther
Title: Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway.
Volume: 14
Issue: 3
Pages: 727-39
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Publication
35154488 | J:320667
First Author: Tang C
Year: 2022
Journal: Theranostics
Title: Hedgehog signaling is controlled by Rac1 activity.
Volume: 12
Issue: 3
Pages: 1303-1320
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Publication
22391310 | J:205031
 
First Author: Huang GJ
Year: 2012
Journal: Vitam Horm
Title: ZFP932 suppresses cellular Hedgehog response and Patched1 transcription.
Volume: 88
Pages: 309-32
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Publication
26254735 | J:227674
 
First Author: Giacomini A
Year: 2015
Journal: Neurobiol Dis
Title: Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.
Volume: 82
Pages: 385-396
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Publication
33028094 | J:318636
First Author: Chapouly C
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Volume: 40
Issue: 12
Pages: e336-e349
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Publication
28734986 | J:257902
 
First Author: Liu X
Year: 2017
Journal: Bone
Title: Exogenous hedgehog antagonist delays but does not prevent fracture healing in young mice.
Volume: 103
Pages: 241-251
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Publication
29463581 | J:262302
First Author: Rahman MM
Year: 2018
Journal: Cancer Res
Title: A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.
Volume: 78
Issue: 10
Pages: 2577-2588
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Publication
30653446 | J:341773
First Author: Niu C
Year: 2019
Journal: Autophagy
Title: Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Volume: 15
Issue: 5
Pages: 843-870
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