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Search results 401 to 472 out of 472 for Bak1

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Type Details Score
Publication
31230859 | J:296482
First Author: Yamashita M
Year: 2019
Journal: Cell Stem Cell
Title: TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Volume: 25
Issue: 3
Pages: 357-372.e7
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Publication
22365665 | J:181625
First Author: Vince JE
Year: 2012
Journal: Immunity
Title: Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
Volume: 36
Issue: 2
Pages: 215-27
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Publication
30485804 | J:270778
First Author: Vince JE
Year: 2018
Journal: Cell Rep
Title: The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
Volume: 25
Issue: 9
Pages: 2339-2353.e4
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Publication
27001308 | J:236189
First Author: Chinnam M
Year: 2016
Journal: Mol Cell Biol
Title: Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Volume: 36
Issue: 11
Pages: 1621-7
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Publication
22491404 | J:196836
First Author: Cammas L
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Integrin-linked kinase deletion in the developing lens leads to capsule rupture, impaired fiber migration and non-apoptotic epithelial cell death.
Volume: 53
Issue: 6
Pages: 3067-81
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Publication
21146511 | J:278909
First Author: Weng SY
Year: 2011
Journal: J Hepatol
Title: Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.
Volume: 54
Issue: 4
Pages: 685-94
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Publication
10618441 | J:59317
First Author: Roth KA
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death.
Volume: 97
Issue: 1
Pages: 466-71
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Publication
10377054 | J:56116
First Author: Exley GE
Year: 1999
Journal: Biol Reprod
Title: Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos.
Volume: 61
Issue: 1
Pages: 231-9
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Publication
15615879 | J:96841
First Author: Gong SG
Year: 2005
Journal: J Dent Res
Title: Identification of markers of the midface.
Volume: 84
Issue: 1
Pages: 69-72
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Publication
33462220 | J:313963
First Author: Zhang Y
Year: 2021
Journal: Cell Death Dis
Title: Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development.
Volume: 12
Issue: 1
Pages: 91
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Publication
30635284 | J:272566
 
First Author: Yang R
Year: 2019
Journal: Development
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Volume: 146
Issue: 2
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Publication
32633719 | J:293992
   
First Author: Mancia Leon WR
Year: 2020
Journal: Elife
Title: Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.
Volume: 9
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Publication
35139355 | J:324833
First Author: Simpson DS
Year: 2022
Journal: Immunity
Title: Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.
Volume: 55
Issue: 3
Pages: 423-441.e9
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Publication
27144312 | J:232560
First Author: Anderson MJ
Year: 2016
Journal: PLoS Genet
Title: An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.
Volume: 12
Issue: 5
Pages: e1006018
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Publication
30655546 | J:270211
First Author: Yang P
Year: 2019
Journal: Nat Commun
Title: Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.
Volume: 10
Issue: 1
Pages: 282
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Publication
19139267 | J:146172
First Author: Wang X
Year: 2009
Journal: J Cell Biol
Title: Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
Volume: 184
Issue: 1
Pages: 143-58
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Publication
29409032 | J:288982
First Author: Assenza MR
Year: 2018
Journal: Cardiovasc Res
Title: Critical role of phosphodiesterase 2A in mouse congenital heart defects.
Volume: 114
Issue: 6
Pages: 830-845
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Publication
30995482 | J:281311
First Author: Nakano Y
Year: 2019
Journal: Cell Rep
Title: Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Volume: 27
Issue: 3
Pages: 860-871.e8
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
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Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Allele
Bak1<em1Smoc> | MGI:7288429
Name: BCL2-antagonist/killer 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
22169508 | -
First Author: Cheng W
Year: 2011
Journal: Cell Host Microbe
Title: Structural analysis of Pseudomonas syringae AvrPtoB bound to host BAK1 reveals two similar kinase-interacting domains in a type III Effector.
Volume: 10
Issue: 6
Pages: 616-26
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Strain
MGI:6428216 | C57BL/6J-Bak1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein Domain
IPR031759 | HopAB_BAK-bd
Type: Domain
Description: HopAB family members are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen []. AvrPtoB, also called HopAB3, is the best studied member of the family. It suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) through binding and inhibiting BAK1, a kinase which serves to activate defense signaling []. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) [].AvrPtoB contains an N-terminal region that contains two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) [, ]. The family member HopPmaL is shorter and lacks the C-terminal E3 ligase domain [].This entry represents the second KID of AvrPtoB that binds to BAK1 thereby preventing its kinase activity after the perception of flagellin [].
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Protein Domain
IPR038342 | HopAB_BAK-bd_sf
Type: Homologous_superfamily
Description: HopAB family members are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen []. AvrPtoB, also called HopAB3, is the best studied member of the family. It suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) through binding and inhibiting BAK1, a kinase which serves to activate defense signaling []. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) [].AvrPtoB contains an N-terminal region that contains two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) [, ]. The family member HopPmaL is shorter and lacks the C-terminal E3 ligase domain [].This entry represents the second KID of AvrPtoB that binds to BAK1 thereby preventing its kinase activity after the perception of flagellin [].
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Publication
29150439 | J:261261
 
First Author: Xia H
Year: 2017
Journal: Sci Immunol
Title: Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.
Volume: 2
Issue: 17
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Publication
22191472 | -
First Author: Singer AU
Year: 2012
Journal: Biochemistry
Title: Structural analysis of HopPmaL reveals the presence of a second adaptor domain common to the HopAB family of Pseudomonas syringae type III effectors.
Volume: 51
Issue: 1
Pages: 1-3
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Publication
21112235 | -
First Author: Oh CS
Year: 2011
Journal: Trends Plant Sci
Title: Effector-triggered immunity mediated by the Pto kinase.
Volume: 16
Issue: 3
Pages: 132-40
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Publication
15808932 | -
First Author: Oguiza JA
Year: 2005
Journal: Res Microbiol
Title: The VirPphA/AvrPtoB family of type III effectors in Pseudomonas syringae.
Volume: 156
Issue: 3
Pages: 298-303
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Publication
19062288 | -
First Author: Göhre V
Year: 2008
Journal: Curr Biol
Title: Plant pattern-recognition receptor FLS2 is directed for degradation by the bacterial ubiquitin ligase AvrPtoB.
Volume: 18
Issue: 23
Pages: 1824-32
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Publication
24312627 | J:211017
First Author: Davis J
Year: 2013
Journal: PLoS One
Title: Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.
Volume: 8
Issue: 12
Pages: e82053
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Publication
20616003 | J:163479
First Author: Guo S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: MicroRNA miR-125a controls hematopoietic stem cell number.
Volume: 107
Issue: 32
Pages: 14229-34
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Publication
21368288 | J:172822
First Author: Surdziel E
Year: 2011
Journal: Blood
Title: Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways.
Volume: 117
Issue: 16
Pages: 4338-48
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Publication
26024858 | J:225531
 
First Author: Chen X
Year: 2015
Journal: Exp Neurol
Title: MiR-125b protects against ethanol-induced apoptosis in neural crest cells and mouse embryos by targeting Bak 1 and PUMA.
Volume: 271
Pages: 104-11
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Publication
24576954 | J:264566
First Author: Wang X
Year: 2014
Journal: Cardiovasc Res
Title: MicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6.
Volume: 102
Issue: 3
Pages: 385-95
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Publication
18667726 | -
First Author: Albrecht C
Year: 2008
Journal: Plant Physiol
Title: Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE proteins serve brassinosteroid-dependent and -independent signaling pathways.
Volume: 148
Issue: 1
Pages: 611-9
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Publication
21693696 | -
First Author: Roux M
Year: 2011
Journal: Plant Cell
Title: The Arabidopsis leucine-rich repeat receptor-like kinases BAK1/SERK3 and BKK1/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens.
Volume: 23
Issue: 6
Pages: 2440-55
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Publication
17626179 | -
First Author: Heese A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants.
Volume: 104
Issue: 29
Pages: 12217-22
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Publication
16284305 | -
First Author: Albrecht C
Year: 2005
Journal: Plant Cell
Title: The Arabidopsis thaliana SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES1 and 2 control male sporogenesis.
Volume: 17
Issue: 12
Pages: 3337-49
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Publication
22253607 | -
First Author: Gou X
Year: 2012
Journal: PLoS Genet
Title: Genetic evidence for an indispensable role of somatic embryogenesis receptor kinases in brassinosteroid signaling.
Volume: 8
Issue: 1
Pages: e1002452
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Publication
27449136 | -
First Author: Zhang H
Year: 2016
Journal: Mol Plant
Title: SERK Family Receptor-like Kinases Function as Co-receptors with PXY for Plant Vascular Development.
Volume: 9
Issue: 10
Pages: 1406-1414
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Publication
27660030 | -
First Author: Ma X
Year: 2016
Journal: Trends Plant Sci
Title: SERKing Coreceptors for Receptors.
Volume: 21
Issue: 12
Pages: 1017-1033
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Protein Domain
IPR038448 | HopAB_E3_ubiquit_lig_sf
Type: Homologous_superfamily
Description: HopAB family members are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen []. AvrPtoB, also called HopAB3, is the best studied member of the family. It suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) through binding and inhibiting BAK1, a kinase which serves to activate defense signaling []. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) [].AvrPtoB contains an N-terminal region that contains two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) [, ]. The family member HopPmaL is shorter and lacks the C-terminal E3 ligase domain [].The E3 ubiquitin ligase domain found in the bacterial protein AvrPtoB inhibits immunity-associated programmed cell death (PCD) when translocated into plant cells, probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. The structure reveals a globular fold centred on a four-stranded β-sheet that packs against two helices on one face and has three very extended loops connecting the elements of secondary structure, with remarkable homology to the RING-finger and U-box families of proteins involved in ubiquitin ligase complexes in eukaryotes [].
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Protein Domain
IPR015133 | E3_ubiquit_lig_AvrPtoB
Type: Domain
Description: HopAB family members are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen []. AvrPtoB, also called HopAB3, is the best studied member of the family. It suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) through binding and inhibiting BAK1, a kinase which serves to activate defense signaling []. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) [].AvrPtoB contains an N-terminal region that contains two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) [, ]. The family member HopPmaL is shorter and lacks the C-terminal E3 ligase domain [].The E3 ubiquitin ligase domain found in the bacterial protein AvrPtoB inhibits immunity-associated programmed cell death (PCD) when translocated into plant cells, probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. The structure reveals a globular fold centred on a four-stranded β-sheet that packs against two helices on one face and has three very extended loops connecting the elements of secondary structure, with remarkable homology to the RING-finger and U-box families of proteins involved in ubiquitin ligase complexes in eukaryotes [].
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Protein Domain
IPR031048 | SERK
Type: Family
Description: The SERK (somatic embryogenesis receptor kinase) family is involved in a wide spectrum of biological processes, including plant development and disease resistance []. SERKs (SERK1-5) are classified as subgroup II receptor-like kinases (RLKs). SERKs exist as coreceptors of multiple cell surface-receptors perceiving diverse stimuli via ligand-induced heterodimerization and transphosphorylation []. They are involved in at least five different signalling pathways [].Arabidopsis SERK1 and SERK2 are functionally redundant and essential for tapetum specification and pollen development during male sporogenesis []. SERK3, also known as BAK1 (BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1), is the coreceptor of the brassinolide (BR)-perceiving receptor BRI1, a function that is BR dependent and partially redundant with SERK1 []. SERK3 controls plant innate immunity and serves as a coreceptor of the flagellin receptor FLS2 []. SERK4 is also involved in innate immunity []. SERK3 and SERK4 are partially redundant in pathogen-induced cell death control []. SERK5 contains a mutation in an important amino acid residue which likely abolishes the kinase activity of SERK [].
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Protein Domain
IPR033743 | HopAB_PID
Type: Domain
Description: HopAB family members are type III effector proteins that are secreted by the plant pathogen Pseudomonas syringae into the host plant to inhibit its immune system and facilitate the spread of the pathogen []. AvrPtoB, also called HopAB3, is the best studied member of the family. It suppresses host basal defenses by interfering with PAMP (pathogen-associated molecular signature)-triggered immunity (PTI) through binding and inhibiting BAK1, a kinase which serves to activate defense signaling []. It also recognizes the kinase Pto to activate effector-triggered immunity (ETI) [].AvrPtoB contains an N-terminal region that contains two kinase-interacting domains (KID) and a C-terminal E3 ligase domain. The first KID recognizes the PTI-associated kinase Bti9 as well as Pto, and is referred to as the Pto-binding domain (PID). The second KID interacts with BAK1 and FLS2, which are leucine-rich repeat-containing receptor-like kinases, and is called the BAK1-interacting domain (BID) [, ]. The family member HopPmaL is shorter and lacks the C-terminal E3 ligase domain [].This entry represents the Pto-binding domain.
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Publication
16373536 | -
First Author: Janjusevic R
Year: 2006
Journal: Science
Title: A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase.
Volume: 311
Issue: 5758
Pages: 222-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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